CAS: 7283-96-7; 2-Chloro-5-Thiophenecarboxaldehyde

上下游产品

CAS号96-43-5 2-氯噻吩 | CAS号68-12-2 N,N-二甲基甲酰胺 | CAS号93-61-8 N-甲基甲酰苯胺 | CAS号50-00-0 甲醛 | CAS号98-03-3 2-噻吩甲醛 | CAS号17249-82-0 2-氯-5-甲基噻吩 | CAS号3437-95-4 2-碘噻吩 | CAS号554-14-3 2-甲基噻吩 | CAS号50478-16-5 5-氯-2-噻吩甲腈 | CAS号22353-82-8 5-氯噻吩-2-甲酰胺 | CAS号868755-64-0 5-(2-呋喃)噻吩-2-甲醛 | CAS号74168-69-7 5-氯-2-噻吩甲醇 | CAS号332099-40-8 2-氯-4H-噻吩并[3,2-... | CAS号332099-38-4 ETHYL 2-CHLORO-... | CAS号13669-19-7 2-(5-氯噻吩-2-基)乙酸 | CAS号133933-81-0 (±)-4-氨基-3-(5-氯... | CAS号17249-82-0 2-氯-5-甲基噻吩 | CAS号19163-21-4 5-苯基-2-噻吩甲醛

2-氯-5-氯甲基噻吩置于苯并[c]噌啉,Sodium Iodide体系中,用 N,N-二甲基甲酰胺 作为反应溶剂,以60%的收率获得产物5-氯噻吩-2-甲醛
参考文献:肼-O2氧化还原对作为有机催化氧化的平台:苯并[c] Cinnoline催化的烷基卤化物氧化为醛类
标题:肼-O2氧化还原对作为有机催化氧化的平台:苯并[c] Cinnoline催化的烷基卤化物氧化为醛类
摘要:描述了一种有机催化氧化平台,该平台利用了肼快速自氧化为二氮烯的能力.在涉及亲核攻击,质变和水解的新型机理范式中,显示出可商购的苯并[C]肉桂啉催化烷基卤化物氧化为醛.仅使用不定形的氧气和水就容易发生水解和再氧化事件.显示了对可行底物范围的调查,以及对这种催化方式有深入了解的机理和计算研究.
DOI:10.1002/anie.201807134

专利信息

专利号:US-5012000-A
优先权日:1989-10-30
标 题 :Total synthesis of chiral 2-amino-1,3-diols
发明人：ILLIG CARL R; WEIS ALEXANDER L
权利人:EASTMAN KODAK CO
摘要:A method for the preparation of chiral 2-amino-1,3-diols is disclosed. The method involves four steps including performance of an aldol condensation with a chiral oxazolidinone on an aldehyde, treating the aldol condensation product with an alkali metal azide, treating the product with a borohydride reagent and reducing the azide to an amine.

专利号:WO-0053313-A2
优先权日:1999-03-09
标 题:Lanthanide catalysts for synthesis of compounds and combinatorial libraries

专利号:KR-20090097208-A
优先权日:2006-12-31
标 题:Process for the synthesis of derivatives of 3-amino-tetrahydrofuran-3-carboxylic acid and use thereof as medicaments

专利号:CN-108840854-B
优先权日:2018-09-18
标 题 :A kind of method for one-pot synthesis of 5-chlorothiophene-2-carboxylic acid

专利号:WO-2008080891-A2
优先权日:2006-12-31
标 题:Process for the synthesis of derivatives of 3-amino-tetrahydrofuran-3-carboxylic acid and use thereof as medicaments

专利号:US-4681891-A
优先权日:1984-11-27
标 题 :Dihydro-2,6-dimethyl pyridines, formulations and method of use for treating angina pectoris, high blood pressure or disturbances of cerebral or peripheral blood flow
发明人：SCHOENAFINGER KARL; BOHN HELMUT; MARTORANA PIERO; NITZ ROLF-EBERHARD
权利人:CASSELLA FARBWERKE MAINKUR AG
摘要:1,4-dihydropyridines of the formula I (I) wherein R1 denotes optionally substituted phenyl, pyridyl or thienyl, R2 denotes optionally substituted oxadiazolyl, thiadiazolyl or thiazolyl and R3 denotes hydrogen or -COOH, their preparation by a modified Hantzsch synthesis and their use as a calcium-agonist in pharmacy.