CAS: 4521-22-6; 4-(P-Tolyl)Butanoic Acid

上下游产品

4-butanolide toluene 6-(4-methylphenyl)-4,5-dihydro-3(2H)-pyridazinone 1-(4-methylphenyl)butan-1-one 7-methyl-3,4-dihydro-2H-naphthalen-1-one 6-methyl-1,2,3,4-tetrahydronaphthalene 4-(4-methylphenyl)butanoyl chloride ethyl 4-(4-methylphenyl)butanoate

3-(4-甲基苯甲酰)丙酸置于palladium 10% On Activated Carbon,氢气体系中,用 乙醇 作为反应溶剂,化学反应生成 4-对甲苯基丁酸
参考文献:叔酰胺作为使用离子对铑配合物进行对映选择性 C−h 胺化的导向基团
标题:叔酰胺作为使用离子对铑配合物进行对映选择性 C−h 胺化的导向基团
摘要:苄基 C−h 键的直接胺化产生重要的立体中心.我们的方法中,双金属铑配合物的手性位于其相关的阳离子上,在含叔酰胺的底物上实现了这一点,得到芳基丁酸和芳基戊酸衍生的酰胺的胺化.我们认为酰胺很可能直接与手性阳离子相互作用,为 C−h 胺化提供高度有序的过渡态.
DOI:10.1002/anie.202317489

专利信息

专利号:WO-2011156355-A1
优先权日:2010-06-09
标题 :Production method of phenyl guanidine salts and their intermediates
发明人：JOHNSON MICHAEL ROSS; KANG MYUNG-CHOL; BRAY BRIAN L; SCHNEIDER STEPHEN
权利人:KAINOS MEDICINE INC; JOHNSON MICHAEL ROSS; KANG MYUNG-CHOL; BRAY BRIAN L; SCHNEIDER STEPHEN
摘要:This invention relates to methods for producing phenyl guanidine salts having pharmacological activity, as well as to the identification and synthesis of compounds useful as intermediates for producing phenyl guanidine salts having pharmacological activity.

专利号:NO-344857-B1
优先权日:2004-02-13
标题:Contrast agents, precursor compounds thereof, preparations containing them, methods of synthesis and their use in imaging