📜4-溴对三联苯置于2,2'-联吡啶,Bis(1,5-Cyclooctadiene)Nickel (0),1,5-Cis,Cis-Cyclooctadiene体系中,用 N,N-二甲基甲酰胺 作为反应溶剂,化学反应 40.0H,以34%的收率获得产物对六联苯 参考文献:Easy Synthesis Of Phenyl Oligomers Using A Ni Complex 标题:Easy Synthesis Of Phenyl Oligomers Using A Ni Complex 摘要:本文介绍了以 4-溴对三联苯和 4-溴对四联苯为起始原料,使用镍络合物,在双吡啶存在下,以 Dmf 作为反应溶剂,分别合成对六联苯和对八联苯的过程.结果表明,这种合成方法不仅提高了产率,而且易于制备和纯化这些亚苯基低聚物. DOI:10.1039/b400236A
专利号:US-2025009786-A1 优先权日:2021-09-30 标 题 :Automated synthesis of polymeric dual drugs 发明人:MATRAY TRACY; VANBRUNT MICHAEL; MCCUTCHEON JOHN MICHAEL 权利人:SONY GROUP CORP 摘要:Compounds useful as biologically active compounds with or without fluorescent or colored dyes are disclosed. In some embodiments, the compounds have the following structure (I): (I) or a stereoisomer, tautomer or salt thereof, wherein R1, R2, R3, R4, R5, R6, R7, L1, L2, L3, L4, L5, L6, L7, L8, L9, L10, L11, M1, M2, M3, l, m, n, p, and q are as defined herein. Additional compound, methods of preparation, pharmaceutical compositions, and methods of treatment related to compounds of Structure (I) are also provided.
专利号:WO-2023052971-A1 优先权日:2021-09-30 标题 :Automated synthesis of polymeric dual drugs
专利号:EP-4408473-A1 优先权日:2021-09-30 标 题:Automated synthesis of polymeric dual drugs
专利号:CN-118159296-A 优先权日:2021-09-30 标题:Automated Synthesis of Polymeric Double Drugs
参考标题:Iodine-Promoted Metal-Free Aromatization: Synthesis Of Biaryls, OligoP-Phenylenes And A-Ring Modified Steroids 作者:Victoriano Domingo,Consuelo Prieto,Alexis Castillo,Lucia Silva,José F. Quílez Del Moral,Alejandro F. Barrero |发布日期:2015.10.12 摘要:Efficient Procedures Based On The Use Of Iodine For The Synthesis Of Biaryls From Arylcyclohexenols Or Arylcyclohexanols Using Sub-Stoichiometric/catalytic Iodine And Dimethyl Sulfoxide (Dmso) As Oxidant. Heteroarylcyclohexanols Also Produced The Corresponding Biaryl Products. It Was Proven That Biphenyl Can Also Be Efficiently Obtained When The Quantity Of Iodine Was Reduced To 0.05 Equiv. The Method