CAS: 2197-63-9; Dihexadecyl Hydrogen Phosphate

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7057-92-3 107-66-4 4621-50-5

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CAS号36653-82-4 十六醇 | CAS号37032-33-0 dihexadecyl pho... | CAS号19047-85-9 双十二烃基磷酸 | CAS号1178568-77-8 ethyl hexadecyl... | CAS号374074-72-3 hexadecyl °Ctad... | CAS号4697-37-4 ethyl metaphosphate | CAS号770-12-7 二氯化磷酸苯酯 | CAS号67-66-3 氯仿

1-十六烷醇置于phosphorus Pentoxide体系中,化学反应 24.0H,反应生成双十六烷基磷酸
参考文献:Alkyl Chain Length Dependency In Hydrolysis Of Liposomal Phosphatidylcholine By Dialkylphosphate.
标题:Alkyl Chain Length Dependency In Hydrolysis Of Liposomal Phosphatidylcholine By Dialkylphosphate.
摘要:因为经常在脂质体磷脂酰胆碱(Pc)分散液中加入带正电或负电的两亲物质,如二烷基磷酸盐或硬脂胺,以防止脂质体聚集,所以我们研究了在存在各种两亲物质的情况下由饱和pc制备的脂质体的长期稳定性.在40oc下储存这些脂质体时,Pc逐渐被带负电的脂质--二烷基磷酸盐水解,而带正电的脂质硬脂胺或不带电的脂质均不水解pc.通过使用具有不同烷基链长度的二烷基磷酸盐(C10,C12,C14,C16,C18和c20)和具有不同脂肪酸链长度的pc(C14,C16和c18),研究了这种pc的水解作用.当二烷基磷酸盐的烷基链长度几乎等于pc的脂肪酸链长度时,水解速率达到最大.也就是说,Pc的二肉豆蔻酰(C14)和二棕榈酰(C16)链的水解作用分别因加入二肉豆蔻基磷酸盐(C14)和二棕榈基磷酸盐(C16)而得到最大程度的加速.Pc的二硬脂酰(C18)链也被加入的二硬脂基磷酸盐(C18)以及二棕榈基磷酸盐(C16)有效地水解.当加入甲基二棕榈基磷酸盐代替二棕榈基磷酸盐,或通过加入乙醇分解脂质体结构时,水解作用没有发生.这些结果表明,二烷基磷酸盐和pc在脂质体中以头对尾的方式排列,并且磷酸盐官能团导致pc的酯键水解.将胆固醇掺入pc双层膜中,在pc的相变温度(Tc)以上抑制了pc的水解,但在tc以下增加了水解.Pc被二烷基磷酸盐水解似乎取决于膜的流动性,并且随着膜流动性的增加而加速,因为胆固醇在tc以上降低了脂质体膜的流动性,而在tc以下增强了膜的流动性.
Doi:10.1248/cpb.43.1751

专利信息

专利号:US-5455157-A
优先权日:1989-05-22
标 题:Method for the non-radioactive measurement of the nucleic acid synthesis in eukaryotic cells
发明人：HINZPETER MATTHIAS; ELTZ HERBERT VON DER
权利人:BOEHRINGER MANNHEIM GMBH
摘要:For the determination of the rate of nucleic acid synthesis in eukaryotic cells a nucleotide which is non-radioactively labelled or derivatized with a hapten is introduced into the cells with the addition of liposomes and the rate of synthesis of the nucleic acids is determined by means of the incorporation of the nucleotide via its label or derivatization.

专利号:US-2023078498-A1
优先权日:2020-02-07
标题 :Targeted Translation of RNA with CRISPR-Cas13 to Enhance Protein Synthesis
发明人：ANDERSON DOUGLAS MATTHEW
权利人:UNIV ROCHESTER
摘要:The present disclosure provides proteins, nucleic acids, systems and methods for enhancing the synthesis of a protein.

专利号:US-2007172520-A1
优先权日:2005-11-18
标题:Immunotargeting of Nonionic Surfactant Vesicles
发明人：VANAUKER MICHAEL; PLAAS ANNA; HOOD ELIZABETH
权利人:UNIV SOUTH FLORIDA
摘要:An immunoniosmes for targeted delivery of therapeutic agents to specific tissues in a host and methods of synthesis of those niosomes. An antibody molecule having specificity for a target antigen, such as a cell surface marker or other marker differentially expressed on a target cell, is covalently coupled to a functionalized membrane constituent. In a particular embodiment the functionalized membrane constituent is polyoxyethylene sorbitan monostearate functionalized with cyanuric chloride. The niosomes of this invention thus provide a composition that enhances internalization or retention of the bioactive agent of the niosome into the cytoplasm of the cells of the target tissue by providing a high degree of target specificity. Furthermore, the membrane vesicle enhances the life of the therapeutic agent by preventing its degradation in the extracellular environment, while exhibiting lower toxicity than can occur with some liposomes. The niosomes of the present invention are thus particularly useful as vehicles for the delivery of therapeutics to specific target cells.

专利号:US-9381477-B2
优先权日:2006-06-23
标题 :Microfluidic synthesis of organic nanoparticles
发明人：KARNIK ROHIT; GU FRANK X; BASTO PAMELA; CANNIZZARO CHRIS; KHADEMHOSSEINI ALIREZA; LANGER ROBERT S; FAROKHZAD OMID C
权利人:KARNIK ROHIT; GU FRANK X; BASTO PAMELA; CANNIZZARO CHRIS; KHADEMHOSSEINI ALIREZA; LANGER ROBERT S; FAROKHZAD OMID C; MASSACHUSETTS INST TECHNOLOGY; BRIGHAM & WOMENS HOSPITAL
摘要:The present invention provides microfluidic systems and methods for the production of particles (e.g., nanoparticles) for drug delivery. The present invention provides microfluidic devices useful for production of particles by nanoprecipitation. The present invention provides highly homogenous compositions of particles produced by inventive microfluidic devices.

专利号:US-2015174549-A1
优先权日:2013-10-25
标 题:High-throughput synthesis of nanoparticles
发明人：LIM JONG-MIN; GILSON LAURA MARIE; CHOPRA SUNANDINI; FAROKHZAD OMID CAMERON; KARNIK ROHIT NANDKUMAR; SWAMI ARCHANA
权利人:LIM JONG-MIN; GILSON LAURA MARIE; CHOPRA SUNANDINI; FAROKHZAD OMID CAMERON; KARNIK ROHIT NANDKUMAR; SWAMI ARCHANA; BRIGHAM AND WOMEN S HOSPITAL CORP; MASSACHUSETTS INST TECHNOLOGY
摘要:A simple and versatile coaxial turbulent jet mixer can synthesize a range of nanoparticles at high throughput, while maintaining the advantages of homogeneity, reproducibility, and tunability that are normally accessible only in specialized microscale mixing devices. Rapid mixing down to a timescale of 7 ms can be achieved by controlling the Reynolds number, providing homogeneous and controllable environments for formation of nanoparticles, for example, by precipitation. The device fabrication does not require specialized machining, making it accessible for a wide range of biomedical laboratories.

专利号:US-6511832-B1
优先权日:1999-10-06
标题:In vitro synthesis of capped and polyadenylated mRNAs using baculovirus RNA polymerase
发明人：GUARINO LINDA A; DONG WEN; JIN JIANPING
权利人:TEXAS A & M UNIV SYS
摘要:The present invention relates to the use of baculovirus RNA polymerase for the production of capped and polyadenylated transcripts in vivo and especially in vitro. More particularly, the purified RNA polymerase of the present invention may be used to produce in vitro transcription and/or in vitro transcription/translation kits.