专利号:US-2015359913-A1 优先权日:2013-01-25 标题:Tetrazines/trans-cyclooctenes in solid phase synthesis of labeled peptides 发明人:REINER THOMAS; LEWIS JASON STUART; WEISSLEDER RALPH; ZEGLIS BRIAN 权利人:SLOAN KETTERING INST CANCER; GEN HOSPITAL CORP 摘要:This invention is in the field of labeled peptide construction for medical treatment and analysis. The invention relates to synthetic labeled peptide compositions, methods of synthesis, and methods of use for the synthetic labeled peptide compositions for medical treatment, imaging, and research purposes.
专利号:US-9169502-B2 优先权日:2010-06-15 标题 :Method of producing L-lysine using a Corynebacterium glutamicum microorganism 发明人:WITTMANN CHRISTOPH; BECKER JUDITH 权利人:WITTMANN CHRISTOPH; BECKER JUDITH; PAIK KWANG IND CO LTD 摘要:The present invention is directed to a method utilizing a recombinant microorganism for the production of aspartate derived amino acids and precursors thereof, in particular for the production of L-lysine. Furthermore, the present invention relates to a recombinant microorganism having improved aspartate-derived amino acid synthesis activity in comparison to the initial microorganism and the use of such microorganisms in producing said amino acids and precursors and derivatives, in particular in the synthesis of L-lysine.
专利号:WO-2011156831-A1 优先权日:2010-06-17 标题 :Formation of nucleic acid within a polymeric capsule 发明人:WARK KIM; CARUSO FRANK; PRICE ANDREW; ZELIKIN ALEXANDER N 权利人:COMMW SCIENT IND RES ORG; UNIV MELBOURNE; WARK KIM; CARUSO FRANK; PRICE ANDREW; ZELIKIN ALEXANDER N 摘要:The present invention provides method of producing a nucleic acid molecule within a polymeric capsule. The method comprises providing a polymeric capsule having entrapped therein a DNA molecule and mixing the capsule with a polymerase and nucleotides, wherein the polymerase and the nucleotides can diffuse into the capsule, to form a reactant mixture. The reactant mixture is then incubated for a time and under conditions such as to allow the de novo synthesis of a nucleic acid molecule within the capsule. The method is particularly useful for the preparation of encapsulated RNAs such as miRNA.
专利号:US-11612873-B2 优先权日:2017-05-31 标 题:Homopolymer encoded nucleic acid memory 发明人:EFCAVITCH J WILLIAM; AGARWALLA SANJAY; ALBIZATI Kim; GRUBBS ALAN W; HOLDEN MATTHEW T; HOPKINS PATRYCJA A; SINGH JAY K 权利人:MOLECULAR ASSEMBLIES INC 摘要:Nucleic acid memory strands encoding digital data using a sequence of homopolymer tracts of repeated nucleotides provides a cheaper and faster alternative to conventional digital DNA storage techniques. The use of homopolymer tracts allows for lower fidelity, high throughput sequencing techniques such as nanopore sequencing to read data encoded in the memory strands. Specialized synthesis techniques allow for synthesis of long memory strands capable of encoding large volumes of data despite the reduced data density afforded by homopolymer tracts as compared to conventional single nucleotide sequences.
专利号:US-10982276-B2 优先权日:2017-05-31 标 题 :Homopolymer encoded nucleic acid memory 发明人:EFCAVITCH J WILLIAM; HOLDEN MATTHEW T 权利人:MOLECULAR ASSEMBLIES INC 摘要:Nucleic acid memory strands encoding digital data using a sequence of homopolymer tracts of repeated nucleotides provides a cheaper and faster alternative to conventional digital DNA storage techniques. The use of homopolymer tracts allows for lower fidelity, high throughput sequencing techniques such as nanopore sequencing to read data encoded in the memory strands. Specialized synthesis techniques allow for synthesis of long memory strands capable of encoding large volumes of data despite the reduced data density afforded by homopolymer tracts as compared to conventional single nucleotide sequences.
专利号:US-11174512-B2 优先权日:2017-05-31 标题:Homopolymer encoded nucleic acid memory 发明人:EFCAVITCH J WILLIAM; HOLDEN MATTHEW T 权利人:MOLECULAR ASSEMBLIES INC 摘要:Nucleic acid memory strands encoding digital data using a sequence of homopolymer tracts of repeated nucleotides provides a cheaper and faster alternative to conventional digital DNA storage techniques. The use of homopolymer tracts allows for lower fidelity, high throughput sequencing techniques such as nanopore sequencing to read data encoded in the memory strands. Specialized synthesis techniques allow for synthesis of long memory strands capable of encoding large volumes of data despite the reduced data density afforded by homopolymer tracts as compared to conventional single nucleotide sequences.
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