CAS: 188637-63-0; (6-Bromopyridin-2-yl)Methanamine

该化合物是一种有机化合物,其特点是存在一个溴原子和一个附于一个丙烯环的有矿物质功能组;该化合物的特点是一个丙烯菊酯,这是一个由六人组成的芳香环,内含一个氮原子,有助于其基本性和形成氢联结的潜力;在六种成分上的溴代谢加强了其再活性,使其在包括药用化学和药物开发在内的各种合成应用中有用;该矿物质组提供了核分裂性特性,允许进一步进行化学修改;通常对六溴-2-丙烯胺等化合物的生物活动进行研究,包括潜在的抗微生物或抗癌特性;不同溶剂的溶解性和稳定性各不相同,影响其在实验室环境中的应用;

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914947-26-5 1956309-87-7 887580-31-6

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上下游产品

6-bromo-2-pyridinecarbaldehyde 2-[(6-bromopyridin-2-yl)methyl]-2,3-dihydro-1H-isoindole-1,3-dione 2-bromo-6-(hydroxymethyl)pyridine 2-bromo-6-(chloromethyl)pyridine N-(6-bromopyridin-2-ylmethyl)-2-nitrobenzenesulfonamide 1-(3,4-difluoro-benzyl)-2-oxo-1,2-dihydro-pyridine-3-carboxylic acid (6-bromo-pyridin-2-ylmethyl)-amide trifluoroacetic acid salt N-((6-bromopyridin-2-yl)-methyl)benzamide 5-Bromo-3-phenylimidazo[1,5-a]pyridine

合成工艺路线路线简述

    📜在 盐酸体系中,用 乙醇,水 用作溶剂,化学反应 14.0H,反应生成6-溴-2-吡啶甲胺
    参考文献:Aryl Fluoroethyl Ureas Acting As Alpha 2 Adrenergic Agents
    标题:Aryl Fluoroethyl Ureas Acting As Alpha 2 Adrenergic Agents
    摘要:本发明提供明确定义的芳基氟代乙基脲,用作选择性的α2肾上腺素能激动剂.因此,所述化合物可用于治疗与α2肾上腺素能受体调节相关的一系列疾病.

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    专利信息


    专利号:US-8962839-B2
    优先权日:2010-11-19
    标题:Chiral spiro-pyridylamidophosphine ligand compound, synthesis method therefor and application thereof
    发明人：ZHOU QILIN; XIE JIANHUA; LIU XIAOYAN; XIE JIANBO; WANG LIXIN
    权利人:ZHOU QILIN; XIE JIANHUA; LIU XIAOYAN; XIE JIANBO; WANG LIXIN; ZHEJIANG JIUZHOU PHARMA SCIENCE & TECHNOLOGY CO LTD
    摘要:The present invention relates to a chiral spiro-pyridylamidophosphine ligand compound, synthesis method therefor and application thereof. The chiral spiro-pyridylamidophosphine compound is a compound having a structure of Formula (I), a racemate or optical isomer thereof, or a catalytically acceptable salt thereof, and is mainly characterized by having a chiral spiro-dihydro-indene skeleton in its structure. The chiral spiro-pyridylamidophosphine compound may be synthesized with optical active 7-diaryl/alkylphosphino-7′-amino-1,1′-spiro-dihydro-indene or substituted 7-diaryl/alkylphosphino-7′-amino-1,1′-spiro-dihydro-indene having a spiro-skeleton as chiral starting material. The chiral spiro-pyridylamidophosphine compound may be used as a chiral ligand in asymmetric hydrogenation of a carbonyl compound catalyzed by iridium, in which the reaction activity is very high, the amount of the catalyst may be 0.0001 mol %, and the enantioselectivity of the reaction is up to 99.9% ee.

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    合成参考文献

    参考DOI号:10.1016/j.bmcl.2011.09.111
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