CAS: 1687-51-0; 2-Aminoquinazoline

相似化合物

190273-89-3 20028-72-2 882670-95-3

上下游产品

CAS号3959-05-5 邻溴苄胺 | CAS号50-01-1 盐酸胍 | CAS号6141-13-5 2-氯喹唑啉 | CAS号6630-33-7 2-溴苯甲醛 | CAS号2305-85-3 5,6,7,8-四氢喹唑啉-2-胺 | CAS号506-93-4 硝酸胍 | CAS号529-23-7 邻氨基苯甲醛 | CAS号106590-52-7 2-phenoxyquinazoline | CAS号631-61-8 乙酸铵

📜2-氯喹唑啉置于盐酸,Sodium Azide体系中,用 乙醇 用作溶剂,化学反应 2.0H,反应生成2-氨基喹唑啉
参考文献:硝基,Diradicals和ylides.2-喹唑基腈的开环扩环和开环
标题:硝基,Diradicals和ylides.2-喹唑基腈的开环扩环和开环
摘要:在200oc和更高的温度下升华,将tetrazolo [1,5-A ]喹唑啉(9)转化为2-Azidoquinquinazoline(10),叠氮化物-四唑平衡受熵控制.2-喹唑基氮烯11和27和/或它们的扩环产物14和29可以经历i型(ylidic)和ii型(diradicaloidoid)开环.的氩气矩阵光解9 / 10,得到2-Quinazolylnitrene(11),它的特点是esr,Uv和ir光谱.还观测到由重排或开环形成的少量第二氮烯.激进主义者(19)通过ii型开环快速形成并通过esr光谱表征; 它在15 K时热衰减,半衰期约为.47分钟,与其计算得出的系统间易穿越性(19T-> 19Oss)相一致,然后轻松进行环化/重排成1-氰基吲唑(21)(计算出的活化屏障1-2 Kcal / Mol)和n-氰基蒽腈(22).21和22是光解的最终产物.21也是闪蒸真空热解的最终产品.零场分裂参数d(cm
Doi:10.1021/jo052541I

专利信息

专利号:US-9242965-B2
优先权日:2013-12-31
标题:Process for the manufacture of (E)-4-N,N-dialkylamino crotonic acid in HX salt form and use thereof for synthesis of EGFR tyrosine kinase inhibitors
发明人：ZHENG JUNCHENG; DENG DA; LV GUANGHUA; YAN JUN; BRANDENBURG JOERG; KROEBER JUTTA; SCHOLZ ULRICH
权利人:BOEHRINGER INGELHEIM INT
摘要:The present invention is directed to an efficient process for the manufacture of (E)-4-N,N-dialkylamino crotonic acid in HX salt form of formula I n nwherein R 1 and R 2 independently denote C 1-3 -alkyl groups and X − denotes an acid anion, such as the chloride, bromide, tosylate, mesylate or trifluoroacetate anion, with high quality, and a process for synthesis of EGFR tyrosine kinase inhibitors with heterocyclic quinazoline, quinoline or pyrimidopyrimidine core structure, using the acid addition salt I and activated derivatives thereof as intermediates.

专利号:WO-9410327-A1
优先权日:1992-10-28
标 题 :Enzymatic synthesis of polyaniline
发明人：ZEMEL HAYA; QUINN JOHN F
权利人:ALLIED SIGNAL INC
摘要:This invention relates to a process for the enzymatic synthesis of electrically conductive substituted and unsubstituted polyanilines. Aniline monomer(s), an oxidizing agent, which comprises an enzyme and an electron acceptor, and an acidifying agent are reacted together to form polyanilines.

专利号:US-9695169-B2
优先权日:2012-05-31
标 题:Synthesis of heterocyclic compounds
发明人：IBRAHIM PRABHA N
权利人:PLEXXIKON INC
摘要:Provided herein are intermediates and processes useful for facile synthesis of biologically active molecules.

专利号:US-5420237-A
优先权日:1991-08-29
标 题:Enzymatic synthesis of polyaniline
发明人：ZEMEL HAYA; QUINN JOHN F
权利人:ALLIED SIGNAL INC
摘要:This invention relates to a process for the enzymatic synthesis of electrically conductive substituted and unsubstituted polyanilines. Aniline monomer(s), an oxidizing agent, which comprises an enzyme and an electron acceptor, and an acidifying agent are reacted together to form polyanilines.

专利号:US-9067944-B2
优先权日:2010-10-21
标题:Process for the preparation of anagrelide and analogues thereof
发明人：MCGEE PAUL
权利人:MCGEE PAUL; SHIRE LLC
摘要:The present invention relates to a novel process for producing anagrelide, 6,7-dichloro-1,5-dihydroimidazo[2,1-b]quinazolin 2(3H)-one, or certain analogs thereof. The process of the invention also provides improved processes for producing key intermediates required for the synthesis of anagrelide or certain analogs thereof.

专利号:RU-2042678-C1
优先权日:1991-05-22
标 题:Method of synthesis of 6,7-dichloro-1,5-dihydroimidazo-[2,1-b]-quinazoline-2-(3h)-one, intermediates for their synthesis and a method of their synthesis