CAS: 15231-48-8; 4-Methylpyrimidin-2(1H)-One

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5348-51-6 51953-13-0 164738-44-7

上下游产品

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2-氯-4-甲基嘧啶置于盐酸,水体系中,化学反应 5.0H,反应生成2-羟基-4-甲基嘧啶
参考文献:膦酸盐取代的二氢嘧啶的氧化还原去外消旋化
标题:膦酸盐取代的二氢嘧啶的氧化还原去外消旋化
摘要:描述了膦酸酯取代的 3,4-Dihydropyrimidin-2-One (Dhpm) 衍生物的有效氧化还原去外消旋.一锅去外消旋策略包括氧化破坏立体中心和随后的不对称转移氢化以再生具有连位膦酸酯基团的手性碳中心,提供一系列具有高达 96% Ee 的光学活性膦酸酯取代的 Dhpm.
Doi:10.1039/d1Ob02079J

专利信息

专利号:US-2007042987-A1
优先权日:2004-07-30
标题:Stereoselective synthesis of beta-nucleosides
发明人：LIN KO-CHUNG; LI WENSEN; LIN CHUNHUI; YUNGSHUN WEIN; KUO-HIS KAO
权利人:LIN KO-CHUNG; LI WENSEN; LIN CHUNHUI; YUNGSHUN WEIN; KUO-HIS KAO
摘要:This invention relates to a process of stereoselectively synthesizing an alcohol of the following formula: n n nwherein R 1 , R 2 , R 3 , R 4 , and R 5 are defined in the specification. The process includes reacting (R) 4-formyl-2,2-dimethyldioxolane with α-bromoacetate in the presence of Zn and a Zn activating agent.

专利号:US-7485716-B2
优先权日:2005-05-02
标题:Stereoselective synthesis of β-nucleosides
发明人：LIN KO-CHUNG; LI WENSEN
权利人:PHARMAESSENTIA CORP
摘要:This invention relates to a process for stereoselectively preparing a nucleoside of the following formula: n nwherein R 3 , R 4 , and B are defined herein. The process includes reacting a furanose compound with a nucleobase in the presence of a halide salt. Also disclosed is another process for stereoselectively synthesizing an intermediate that can be used to make the starting compound in the first-mentioned process.

专利号:US-8193339-B2
优先权日:2007-11-06
标 题 :Synthesis of β-nucleosides
发明人：CHU CHI-YUAN; LEE WEI-DER; LI WENSEN; HWANG CHAN KOU
权利人:CHU CHI-YUAN; LEE WEI-DER; LI WENSEN; HWANG CHAN KOU; PHARMAESSENTIA CORP
摘要:This invention relates to a process of stereoselectively synthesizing a β-nucleoside compound of formula (I): n nwherein R 1 , R 2 , and B are as defined in the specification; each of R 3 and R 4 , independently, is H or fluoro. The process includes reacting, in the presence of a transition metal salt, a tetrahydrofuran compound of formula (II):n n nwherein R 1 , R 2 , and L are as defined in the specification, with a nucleobase derivative; and each of R 3 and R 4 , independently, is H or fluoro.

专利号:US-8344118-B2
优先权日:2007-10-31
标 题 :Preparation and isolation of 5′ capped MRNA
发明人：KORE ANILKUMAR; MUTHIAN SHANMUGASUNDARAM; CHARLES IRUDAYA
权利人:APPLIED BIOSYSTEMS LLC; KORE ANILKUMAR; MUTHIAN SHANMUGASUNDARAM; CHARLES IRUDAYA
摘要:The synthesis of capped/tagged RNA, methods of use and kits providing same are contemplated. Tagged RNA permits isolation of RNA transcripts in vitro. The ability to isolate and purify capped RNA results in improved transcription and translation and provides a tool for identifying RNA-protein interactions. Such capped RNA finds use in therapeutic applications, diagnosis and prognosis and in the treatment of cancers and HIV.

专利号:US-2007015914-A1
优先权日:2005-05-02
标 题:Stereoselective synthesis of beta-nucleosides

专利号:US-2009124797-A1
优先权日:2007-11-06
标 题:Novel synthesis of beta-nucleosides