CAS: 149793-69-1; 3-Fluoro-5-(Trifluoromethyl)Benzonitrile

相似化合物

161622-05-5 188815-30-7 207986-20-7

3-氨基-5-氰基三氟甲苯置于iron(III) Chloride,Pyrilium Tetrafluoroborate,Sodium Fluoride体系中,用 Neat (No Solvent,Solid Phase) 用作溶剂,以92 %的收率获得3-氟-5-(三氟甲基)苯甲腈
参考文献:纳米纤维素作为 Fecl3 介导的(杂)芳香胺机械化学脱氨氟化反应介质
标题:纳米纤维素作为 Fecl3 介导的(杂)芳香胺机械化学脱氨氟化反应介质
摘要:开发一种有效替代广泛使用的 Balz-Schiemann 脱氨基氟化方法(即不使用芳基重氮四氟硼酸盐)是一项具有挑战性的任务.在此,我们报道了一种方便的一锅法,用于 Fecl3-纳米纤维素介导的氟代芳烃的机械化学合成,通过使用四氟硼酸吡喃鎓 (Pyry-Bf4) 和氟化钠 (Naf) 原位形成,用氟基团选择性取代芳香氨基吡啶鎓盐中间体.本协议的范围包括通过氟选择性取代(snar)氨基以优异的收率合成二十八种有机氟化合物.所提出的简洁方法为制药行业后期功能化开辟了进入新化学空间的途径.
Doi:10.1002/adsc.202400303

专利信息

专利号:US-7709657-B2
优先权日:2005-06-09
标 题:Process for the synthesis of organic compounds
发明人：ACEMOGLU MURAT; SCHENKEL BERTHOLD; SHIEH WEN-CHUNG; XUE SONG; WIDMER ERICH; GARCIA FUENTES PEDRO; MARTIN MEDINA JOSE; VICENTE BANOS FRANCISCO
权利人:NOVARTIS AG
摘要:The present invention provides an efficient, safe and cost effective way to prepare 5-(4-methyl-1H-imidazol-1-yl)-3-(trifluoromethyl)-benzenamine which is an intermediate for the preparation of substituted pyrimidinylaminobenzamides of formula (II):

专利号:US-8008504-B2
优先权日:2005-06-09
标题 :Process for the synthesis of organic compounds
发明人：ABEL STEPHAN; ACEMOGLU MURAT; ERB BERNHARD; KRELL CHRISTOPH; SCLAFANI JOSEPH; MEISENBACH MARK; PRASHAD MAHAVIR; SHIEH WEN-CHUNG; XUE SONG
权利人:NOVARTIS AG
摘要:The present invention provides an efficient, safe and cost effective way to prepare 5-(4-methyl-1H-imidazol-1-yl)-3-(trifluoromethyl)-benzenamine which is a key intermediate for the preparation of substituted pyrimidinylaminobenzamides of formula (II):

专利号:US-2008200692-A1
优先权日:2005-06-09
标 题:Process For the Synthesis of Organic Compounds

专利号:ES-2380489-T3
优先权日:2005-06-09
标 题 :Process for the synthesis of organic compounds

专利号:ES-2465522-T3
优先权日:2005-06-09
标 题:Process for the synthesis of organic compounds

专利号:CA-2611280-A1
优先权日:2005-06-09
标题 :Processes for the synthesis of 5-(4-methyl-1h-imidazol-1-yl)-3-(trifluoromethyl)-benzenamine and its intermediates