CAS: 107582-20-7; Methyl 2,3-Diaminobenzoate

相似化合物

57113-91-4 603-81-6 1261647-99-7

上下游产品

苯甲酸,二氨基- 2,3-Diaminobenzoic Acid 603-81-6
邻氨基苯甲酸甲酯 2-Carbomethoxyaniline 134-20-3
2-氨基-3-硝基苯甲酸甲酯 Methyl 3-Nitroanthranilate 57113-91-4
2-氨基-6-硝基苯甲酸甲酯 Methyl 3-Amino-2-Nitrobenzoate 1261647-99-7
2-氨基-3-硝基苯甲酸 3-Nitroanthranilic Acid 606-18-8
Methyl 3-Amino-2-[(Tert-Butoxycarbonyl)Amino]Benzoate 474708-09-3
2-氨基-5-氯-3-硝基苯甲酸甲酯 Methyl 2-Amino-5-Chloro-3-Nitrobenzoate 84228-49-9
2-乙酰苯甲酸甲酯 Methyl 2-(Acetylamino)Benzoate 06/08/2719

阿齐沙坦酯杂质3置于tin,水体系中,用 乙酸乙酯,甲苯 用作溶剂,化学反应 4.0H,反应生成2,3-二氨基苯甲酸甲酯
参考文献:一种2-乙氧基苯并咪唑-7-羧酸甲酯的合成方 法
标题:一种2-乙氧基苯并咪唑-7-羧酸甲酯的合成方 法
摘要:本发明公开了一种2‑乙氧基苯并咪唑‑7‑羧酸甲酯的合成方法,解决现有工艺含量不高,收率极低的问题.本发明是以3‑硝基邻苯二甲酸为原料,经甲酯化,酰化,重氮化后在水溶液中重排,再经锡粉还原,合环,得到2‑乙氧基苯并咪唑‑7‑羧酸甲酯.本发明的合成方法产生杂质极少,含量高,且收率也极高.

专利信息

专利号:US-9993570-B2
优先权日:2014-01-05
标题:Radiolabeled tracers for poly (ADP-ribose) polymerase-1 (PARP-1), methods and uses therefor
发明人：MACH ROBERT; CHU WENHUA; ZHOU DONG; MICHEL LOREN; CHEN DELPHINE
权利人:UNIV WASHINGTON
摘要:Disclosed are PARP-1 inhibitors, which can be 18 F-labeled for use as tracers in positron emission tomographic (PET) imaging. Further disclosed are methods of synthesis. Of the compounds synthesized, 2-[p-(2-Fluoroethoxy)phenyl]-1.3.10-triazatricyclo[6.4.1.0 4,13 ]trideca-2,4(13),5,7-tetraen-9-one (12) had the highest inhibition potency for PARP-1 (IC 50 =6.3 nM). Synthesis of [ 18 F]-12 is disclosed under conventional conditions in high specific activity with 40-50% decay-corrected yield. MicroPET imaging using [ 18 F]-12 in MDA-MB-436 tumor-bearing mice demonstrated accumulation of [ 18 F]-12 in a tumor. Binding, can be blocked by olaparib. The compounds have utility for tumor imaging.

专利号:US-2016207909-A1
优先权日:2015-01-20
标 题 :Synthesis Method of Anti-Cancer Drug UK-1 and Derivatives Thereof
发明人：HUANG YUNG-TZUNG
权利人:HUANG YUNG-TZUNG
摘要:A synthesis method of anti-cancer drug UK-1 includes: mixing methyl 2-amino-3-hydroxybenzoate, aldehyde and molecular sieves to form a mixture and firstly refluxing the mixture to form a first reactant; hydrolyzing the first reactant in a basic solution to form a hydrolyzed solution and secondly refluxing the hydrolyzed solution to form a second reactant; and dehydrating the second reactant and the methyl 2-amino-3-hydroxybenzoate in an acidic solution to form a dehydrated solution and thirdly refluxing the dehydrated solution to form an anti-cancer drug UK-1 or at least one derivative thereof.

专利号:US-7541367-B2
优先权日:2005-05-31
标 题 :3-benzoimidazolyl-pyrazolopyridines useful in treating kinase disorders
发明人：CHIU GEORGE; CONNOLLY PETER J; EMANUEL STUART; HUANG SHENLIN; LI SHENGJIAN; LIN RONGHUI; LU YANHUA; MIDDLETON STEVEN A
权利人:JANSSEN PHARMACEUTICA NV
摘要:The present invention is directed to novel 3-benzoimidazolyl-pyrazolopyridine compounds of formula (I): n nand pharmaceutically acceptable forms thereof and their synthesis and use as inhibitors of serine-threonine protein kinases and tyrosine protein kinases and interactions thereof.

专利号:CN-116606491-A
优先权日:2023-05-16
标 题 :A kind of anti-aging PE material and its synthesis process