CAS: 843666-40-0; 18-(Tert-Butoxy)-18-Oxooctadecanoic Acid

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CAS号871-70-5 十八烷二酸 | CAS号36805-97-7 N,N-二甲基甲酰胺二叔丁基缩醛

octadecanedioyl Dichloride置于吡啶,水体系中,用 二氯甲烷,N,N-二甲基甲酰胺 作为反应溶剂,化学反应 5.0H,反应生成 18-[(2-甲基-2-丙基)氧基]-18-氧代十八烷酸
参考文献:一种制备脂肪二酸衍生物的方法及其应用
标题:一种制备脂肪二酸衍生物的方法及其应用
摘要:本发明公开了一种制备脂肪二酸衍生物的方法及其应用.该方法是先将长链脂肪二酸和二氯亚砜反应,得到酰氯;将酰氯与叔丁醇反应,再去除氯基团,得到长链脂肪二酸一叔丁酯;接着和n‑羟基琥珀酰亚胺反应,长链脂肪二酸琥珀酰亚胺基叔丁基酯;接着与l‑谷氨酸‑1‑叔丁酯反应,得到叔丁基长链脂肪二酰基‑l‑glu‑otbu;再与n‑羟基琥珀酰亚胺反应,得到叔丁基长链脂肪二酰基‑l‑glu(Osu)‑otbu;最后将叔丁基长链脂肪二酰基‑l‑glu(Osu)‑otbu中的叔丁基去除,得到长链脂肪二酸衍生物.该方法的路线操作简便,质量可控,适合工业放大生产,且成本低,同时纯化简单,适合用于制备高纯度的胰岛素类似物.

专利信息

专利号:US-2019177392-A1
优先权日:2014-09-23
标 题 :Synthesis of glp-1 peptides
发明人：PENIAS NAVON SHARON; NAVEH SHIRLY; VASILEIOU ZOI; BARLOS KONSTANTINOS
权利人:NOVETIDE LTD
摘要:Disclosed are processes for the synthesis of GLP-1 peptides, such as liraglutide and semaglutide, and a process for purifying liraglutide.

专利号:US-11186608-B2
优先权日:2017-12-21
标 题 :Solid phase synthesis of acylated peptides
发明人：SCHOENLEBER RALPH O; LOIDL GUENTHER
权利人:BACHEM HOLDING AG
摘要:The present invention relates to methods and compounds for the solid phase synthesis of peptides carrying a substituent at an amino group of an amino acid side chain.

专利号:US-2023295077-A1
优先权日:2020-04-10
标题:An improved process for the preparation of semaglutide side chain
发明人：PANDEY MANEESH KUMAR; SHUKLA SONU PRASAD; NAIN SACHIN; SANDEEP SANDEEP; MALE SRIDHAR; SOKHI SARBJOT SINGH; SINGH GOVIND; LAHIRI SASWATA; CABRI WALTER
权利人:FRESENIUS KABI ONCOLOGY LTD
摘要:The present invention relates to an improved process for the preparation of a compound of Formula (1), The invention also provides improved processes for the preparation of intermediates used in the synthesis of Formula (1). The compound of Formula (1) is used in the synthesis of Semaglutide.

专利号:US-12441760-B2
优先权日:2013-08-29
标 题 :Amino diacids containing peptide modifiers
发明人：BARLOS KLEOMENIS; GATOS DIMITRIOS; BARLOS KOSTAS K; VASILEIOU ZOI
权利人:CHEMICAL & BIOPHARMACEUTICAL LABORATORIES OF PATRAS S A
摘要:The present invention relates to peptide modifier compounds of Formula (1), or a salt thereof, wherein: a is an integer from 1 to 10, more preferably from 1 to 3; b is an integer from 0 to 7; Z is a terminal group and Y is a bivalent group. Further aspects of the invention relate to intermediates in the preparation of compounds of Formula (1), and the use of compounds of Formula (1) in the synthesis of peptide derivatives.

专利号:US-11970523-B2
优先权日:2018-07-25
标 题 :Long-acting oxyntomodulin hybrid peptide, preparation method therefor, and application thereof
发明人：QIAN HAI; HUANG WENLONG; CAI XINGGUANG; LI CHENGYE; LIU CHUNXIA; DAI YUXUAN
权利人:UNIV CHINA PHARMA
摘要:The present invention discloses a polypeptide and application thereof. By modifying oxyntomodulin (OXM), hybridizing OXM with a peptide sequence of Exenatide, including enabling the polypeptide to be resistant to DPP-4 enzyme degradation through amino acid modification, and conjugating fatty acid chains at the same time, an OXM hybrid peptide having longer pharmacologic action time and better weight losing effects is obtained. Synthesis of a target polypeptide is fast realized by an orthogonal protection strategy solid-phase synthesis method, and a crude product is purified and freeze-dried to obtain the OXM hybrid peptide.

专利号:CN-114981285-A
优先权日:2020-12-26
标 题 :Synthesis of C-terminal Protected Fragments of Peptides