CAS: 67909-30-2; 4-Methyl-7-(((2S,3S,4S,5S,6R)-3,4,5-Trihydroxy-6-(Hydroxymethyl)Tetrahydro-2H-Pyran-2-yl)Oxy)-2H-Chromen-2-One
该化合物是合成胶合胶合物,通常用作生物化学分析的基质,特别是用于检测-mannosidase活动.该化合物具有4-甲基苯丙酰氟基酮基质(一种四甲基苯二烯基酮),与-D-甲诺基甲酸酯相连接,与一个-D2-甲诺伊色分解装置相连.通过酶水解释放的荧光体,使它成为各种酶研究和实验中的一种宝贵工具.它通常是白色到白色的,在水和有机溶剂中溶解,便于其在各种实验条件下使用.该混合物在标准实验室条件下稳定,但应储存在一个冷干的地方以保持其完整性.其应用范围扩大到对碳水化合物代谢,酶动能学和液晶体研究.应参考安全数据表,以便处理和处置准则,与所有化学物质一样.总体而言,4-甲酰氟-D甲胺-甲胺基甲氨基氨基-甲氨氨基磺酸盐酯是生物和分子生物学领域的一个重要试剂.
- 英文名称4-Methyl-7-(((2S,3S,4S,5S,6R)-3,4,5-Trihydroxy-6-(Hydroxymethyl)Tetrahydro-2H-Pyran-2-yl)Oxy)-2H-Chromen-2-One
- 中文名称4-甲基伞形酮 β-D-甘露糖苷
- IUPAC名称4-methyl-7-(((2S,3S,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)-2H-chromen-2-one
- 其它别名4-Methylumbelliferyl Beta-D-Mannopyranoside; 4-Methylumbelliferyl Beta-D-Mannoside; 4-Methylumbelliferyl B-D-Mannopyranoside; 4-Mu-Beta-D-Man; 4-Methylumbelliferyl β-D-Mannoside; 4-Methyl-7-[(2S,3S,4S,5S,6R)-3,4,5-Trihydroxy-6-(Hydroxymethyl)Oxan-2-Yl]Oxy-Chromen-2-One; 4-Methyl-7-[(2S,3S,4S,5S,6R)-3,4,5-Trihydroxy-6-(Hydroxymethyl)Oxan-2-Yl]Oxychromen-2-One; 4-Methyl-7-[(2S,3S,4S,5S,6R)-3,4,5-Trihydroxy-6-Methylol-Tetrahydropyran-2-Yl]Oxy-Coumarin
- CAS编号67909-30-2
- MFCD编号:MFCD00069855
- 分子式:C16H18O8分子量:338.31
- 产品CID: 1664722
- 产品分类生物化工 → 糖类化合物 → 单糖
物理性质
合成工艺路线路线简述
海关参考信息
- 2905122000-异丙醇
2905310000-1,2-乙二醇
2905320000-1,2-丙二醇
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品牌试剂参考报价(招募中)
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主要参考文献
参考标题:Saponin Derivatives Useful For Inhibiting Sialyltransferase And Biosynthesis Of Sialoglycoconjugate摘要:The Invention Provides The Use Of The Saponin Derivatives, Which Is Of The General Formula (I) Or The Pharmaceutically Acceptable Salts And Esters Thereof: 1 R 1 Is Hydrogen, C 1-8 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, Or C 1-8 Alkylhydroxy; R 2 Is Hydrogen, C 1-8 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, Cooh, Cooc 1-8 Alkyl; R 3 Is C 1-8 Alkylhydroxy, Hydrogen, C 1-8 Alkyl, C2-6 Alkenyl Or C 2-6 Alkynyl; R 4 Is A Sugar Residue; And M Is 0, 1, 2 Or 3; And Pharmaceutically Acceptable Carriers, As Well As The Use Of Such Pharmaceutical Composition In The Inhibition Of Sialyltransferases.
合成参考文献
参考文献:10.1038/nchembio.81|10.2210/pdb2vjx/pdb|10.2210/pdb2vl4/pdb|10.2210/pdb2vmf/pdb|10.2210/pdb2vo5/pdb|10.2210/pdb2vot/pdb|10.2210/pdb2vqt/pdb|10.2210/pdb2vqu/pdb
摘要:Tailford LE, Offen WA, Smith NL, Dumon C, Morland C, Gratien J, Heck MP, Stick RV, Blériot Y, Vasella A, Gilbert HJ, Davies GJ. Structural and biochemical evidence for a boat-like transition state in beta-mannosidases. Nat Chem Biol. 2008 May;4(5):306–12. doi: 10.1038/nchembio.81.
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