CAS: 62973-76-6; 4-[(E)-2-(1-Methyl-5-Nitroimidazol-2-yl)Ethenyl]Pyrimidin-2-Amine

📜3'-甲氧基乙酰苯胺置于吡啶,三氯化铝,水,氢溴酸,三溴化硼,Sodium Hydride,Sodium Chloride体系中,用 乙醇,二氯甲烷,溶剂黄146,甲苯 作为反应溶剂,化学反应 19.5H,反应生成 嘧啶硝唑
参考文献:新的抗过敏性吡喃并[3,2-G]喹啉-2,8-二羧酸,可能会局部治疗哮喘.
标题:新的抗过敏性吡喃并[3,2-G]喹啉-2,8-二羧酸,可能会局部治疗哮喘.
摘要:已经合成了许多潜在用于哮喘局部治疗的抗过敏性吡喹啉二羧酸衍生物.所有化合物均已针对大鼠被动皮肤过敏反应和狗低血压筛查进行了评估.这是后一种筛选方法用于识别抗过敏剂的第一个详细说明.两种化合物,9-乙基-6钠,9-二氢-4,6-二氧代-10-丙基-4H-吡喃[3,2-G]喹啉-2,8-二羧酸酯(86)和6-(甲氨基二钠))-4-氧代-10-丙基-4H-吡喃并[3,2-G]-喹啉-2,8-二羧酸酯(72),并进一步评估了它们诱导78000分子量相关蛋白磷酸化的能力与大鼠腹膜肥大细胞.还已经评估了它们抑制组胺从这些细胞和粘膜肥大细胞制剂中释放的能力.这些化合物,奈多克罗米钠(tilade 86)和米诺克罗米尔(72的游离酸),目前正在接受治疗评估.讨论了筛选程序的原理以及这些二元酸的第二羧酸功能与受体结合的相关性.
DOI:10.1021/jm00150A014

专利信息

专利号:WO-2025085030-A1
优先权日:2023-10-18
标 题:Synthesis of semisynthetic penicillin derivatives containing hydrazone-derived thiazolidine and imidazole ring
发明人：SARIPINAR EMIN; BURAN SUMEYYE
权利人:ERCIYES UNIV
摘要:The present invention relates to the novel semi-synthetic thiazolidine and imidazole penicillin, pharmaceutically acceptable derivatives thereof and their synthesis method that may cause biologically significant changes by the N-acylation reaction of 6-aminopenicillanic (6-APA) using new trisubstituted thiazolidine and imidazole acetyl chloride derivatives. The invention also relates to pharmaceutical compositions comprising these compounds and their use for therapeutic treatment in the human or animal body.

专利号:WO-2025085026-A1
优先权日:2023-10-18
标 题:Synthesis of semisynthetic penicillin derivatives containing hydrazone-derived thiazolidine and imidazole ring
发明人：SARIPINAR EMIN; BURAN SUMEYYE
权利人:T C ERCIYES UNIV
摘要:The present invention relates to the novel semi-synthetic thiazolidine and imidazole penicillin, pharmaceutically acceptable derivatives thereof and their synthesis method that may cause biologically significant changes by the N-acylation reaction of 6-aminopenicillanic (6-APA) using new trisubstituted thiazolidine and imidazole acetyl chloride derivatives. The invention also relates to pharmaceutical compositions comprising these compounds and their use for therapeutic treatment in the human or animal body.

专利号:US-2014315720-A1
优先权日:2012-10-24
标 题 :Polysaccharide ester microspheres and methods and articles relating thereto
发明人：FALLON DENIS G; GARRETT THOMAS S; KIZER LAWTON E; ZAZZARA KAREN L; COMBS MICHAEL T; JOHNSON RICHARD K; DEHART GARY
权利人:CELANESE ACETATE LLC
摘要:A method for producing a polysaccharide ester microsphere may include forming a polysaccharide ester product from a polysaccharide synthesis, wherein the polysaccharide ester product comprises a polysaccharide ester and a solvent; diluting the polysaccharide ester product, thereby yielding a polysaccharide ester dope; and forming a plurality of polysaccharide ester microspheres from the polysaccharide ester dope. Suitable polysaccharides may include, but are not limited to, starch, cellulose, hemicellulose, algenates, chitosan, and any combination thereof. Esters thereof may be organic esters (e.g., acetate and the like), inorganic esters (e.g., sulfonates and the like), or combinations thereof. Further, the solids conent of the polysaccharide ester dope, in some instances, may be greater than about 16 wt %.