CAS: 627-63-4; Fumaryl Chloride

上下游产品

maleic anhydride Phthaloyl dichloride succinoyl dichloride Benzotrichloridr,2t-dicarboxylic acid dimethyl ester(+/-)-4,4-dimethoxy-cyclohexane-1r,2t-dicarboxylic acid dimethyl ester rac-(1S,2S)-dimethyl 4-ox°Cyclohexane-1,2-dicarboxylate fumaric acid bis-(2,2,2-trichloro-ethyl ester) -fumaratBis-2,2,2-tribromoethyl-fumarat

📜马来酸酐置于perchloro-2-Aza-1-Propene,Zinc(II) Chloride体系中,化学反应生成 反丁烯二酰氯
参考文献:Reaktionen Der Substituierten 1,3,3-Trichloro-2-Aza-Propene [n-(1,1-Dichloro-Alkyl)-Imidchloride]
标题:Reaktionen Der Substituierten 1,3,3-Trichloro-2-Aza-Propene [n-(1,1-Dichloro-Alkyl)-Imidchloride]
摘要:多氯-2-氮丙烯可通过高温氯化烷基异氰二氯化物,N-烷基亚胺基氯和席夫碱1来容易地获得.目前的综述调查了该系列中最低代表物五氯-2-氮丙烯(三氯甲基异氰二氯化物,Tmi)的合成上有用的反应,并表明通过较高同系物的1,3,3-三氯-2-氮丙烯也可以进行环闭合反应. 1. 三氯甲基异氰二氯化物(tmi)的分子断裂反应 1.1. Tmi的水解 1.2. Tmi的分子内脱水 1.3. Tmi与醇的反应 1.4. Tmi与羧酸的反应 1.5. Tmi与磺酸的反应 2. 三氯甲基异氰二氯化物(tmi)与羰基的反应 2.1. 醛转化为1,1-二氯烷烃 2.2. 羧酸酐转化为酰氯 3. 三氯甲基异氰二氯化物(tmi)作为碳酸衍生物的反应(正碳酸盐的合成) 3.1. Tmi与单功能酚和三氯乙醇的反应 3.2. Tmi与多功能酚的反应 4. 合成涉及将三氯甲基异氰二氯化物(tmi)或取代的1,3,3-三氯-2-氮丙烯的c-3原子并入n-杂环化合物 4.1. 1,3,5-三嗪的合成 4.2. 嘧啶的合成 4.3. 喹唑啉的合成 4.4. 1,2,4-三唑的合成 4.5. 1,2,4-噁二唑的合成
DOI:10.1055/s-1972-21944

专利信息

专利号:US-7888337-B2
优先权日:2007-08-31
标 题 :Synthesis of oseltamivir containing phosphonate congeners with anti-influenza activity
发明人：WONG CHI-HUEY; FANG JIM-MIN; SHIE JIUN-JIE; CHENG YIH-SHYUN EDMOND; JAN JIA-TSRONG
权利人:ACADEMIA SINICA
摘要:Novel phosphonate compounds are described. The compounds have activity as neuraminidase inhibitors against wild-type and H274Y mutant of H1N1 and H5N1 viruses. The present disclosure also provides an enantioselective synthetic route to known neuraminidase inhibitors oseltamivir and the anti-flu drug Tamiflu®, as well as novel phosphonate compounds, via D-xylose. Another efficient and flexible synthesis of Tamiflu and the highly potent neuraminidase inhibitor Tamiphosphor was also achieved in 11 steps and >20% overall yields from the readily available fermentation product (1S-cis)-3-bromo-3,5 -cyclohexadiene-1,2-diol. Most of the reaction intermediates were obtained as crystals without tedious purification procedures. The key transformations include an initial regio- and stereoselective bromoamidation of a bromoarene cis-dihydrodiol, as well as the final palladium-catalyzed carbonylation and phosphonylation.

专利号:US-9365874-B2
优先权日:2007-08-10
标 题 :Methods for synthesis of olefins and derivatives
发明人：BURK MARK J; PHARKYA PRITI; VAN DIEN STEPHEN J; BURGARD ANTHONY P; SCHILLING CHRISTOPHE H
权利人:GENOMATICA INC
摘要:The invention provides a method of producing acrylic acid. The method includes contacting fumaric acid with a sufficient amount of ethylene in the presence of a cross-metathesis transformation catalyst to produce about two moles of acrylic acid per mole of fumaric acid. Also provided is an acrylate ester. The method includes contacting fumarate diester with a sufficient amount of ethylene in the presence of a cross-metathesis transformation catalyst to produce about two moles of acrylate ester per mole of fumarate diester. An integrated process for process for producing acrylic acid or acrylate ester is provided which couples bioproduction of fumaric acid with metathesis transformation. An acrylic acid and an acrylate ester production also is provided.

专利号:US-4000358-A
优先权日:1968-12-19
标题:Unsaturated ester-amides of halogenated alkenes
发明人：D ALELIO GAETANO F
权利人:ALELIO GAETANO F D
摘要:This invention deals with new unsaturated esteramides of alpha , beta -unsaturated polycarboxylic acids derived from halogenated alcohols of the formula wherein R is a divalent hydrocarbon moiety having at least one and no more than 10 carbon atoms, X is a member selected from the class of bromine and chlorine, and R' is a member selected from the class of hydrogen, X and a monovalent hydrocarbon containing at least one and no more than 20 carbon atoms. Typical esteramides are the maleates, fumarates, itaconates and citraconates. These monomers possess fire-retardant properties and are useful for the synthesis of polymers and copolymers.

专利号:US-8304553-B2
优先权日:2007-12-19
标题:Method of forming oseltamivir and derivatives thereof
发明人：LIU XUEWEI; MA JIMEI
权利人:LIU XUEWEI; MA JIMEI; UNIV NANYANG TECH
摘要:A process is provided for the synthesis of 4,5-diamino cyclohexene carboxylate ester (1): or a pharmaceutically acceptable salt thereof. R 1 -R 3 are a silyl-, an aliphatic, alicyclic, aromatic, arylaliphatic, or an arylalicyclic group. R 4 , R 11 and R 12 are H, a silyl-group, an aliphatic, alicyclic, aromatic, arylaliphatic, or an arylalicyclic group. 3,4-Dihydropyran compound (9): with R 5 and R 6 being suitable protecting groups, is reacted to form aldehyde (4): which is oxidized and converted to N-substituted carbamate (3): with R 7 being a suitable protecting group. (3) is, via oxazolinidone (13): converted to azido carboxylate ester (2): and then to 4,5-diamino cyclohexene carboxylate ester (1).

专利号:US-2019055337-A1
优先权日:2016-02-02
标题 :Low-cost synthesis of macromonomers
发明人：MAYS JIMMY W; KANG NAM-GOO; WANG WEIYU; WANG HUIQUN
权利人:UNIV TENNESSEE RES FOUND
摘要:Methods of preparing macromonomers, e.g., single- or double-tailed macromonomers, using radical polymerization of a first monomer in solution or in an emulsion are described. Methods of using the macromonomers in the preparation of multigraft copolymers are also described. For instance, the macromonomer prepared by radical polymerization can be used in an emulsion copolymerization with a second monomer to form a random multigraft copolymer. The random multigraft co-polymers can be superelastomers.

专利号:US-5635157-A
优先权日:1992-04-13
标 题 :Synthesis of 4-substituted-trans-1,2-diaminocyclohexyl polyaminocarboxylate metal chelating agents for the preparation of stable radiometal antibody immunoconjugates for therapy and spect and pet imaging
发明人：MEASE RONNIE C; KOLSKY KATHRYN L; MAUSNER LEONARD F; SRIVASTAVA SURESH C
摘要:Cyclohexyl chelating agents useful in forming antibody-metal conjugates useful for diagnostic and therapeutic purposes. New compounds and processes of forming these compounds are disclosed including 4-haloacetamido-trans-1,2-diaminocyclohexyl polyaminocarboxylate and 4-isothiocyanato-trans-1,2-diamino cyclohexane-N, N, N', N'-tetra acetic acid.