CAS: 614-69-7; 2-Methylphenyl Isothiocyanate

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CAS号74467-03-1 N-hydroxy-2-met... | CAS号463-71-8 硫光气 | CAS号95-53-4 邻甲苯胺 | CAS号75-15-0 二硫化碳 | CAS号94-69-9 2'-甲基甲酰苯胺 | CAS号785-49-9 o-phenyl o-toly... | CAS号1005-56-7 氯化硫代甲酸苯酯 | CAS号17425-17-1 Carbamodithioic... | CAS号10468-64-1 2-苄基(苯甲基)异氰化 | CAS号108288-50-2 (4H-苯并[d][1,3]-... | CAS号10532-63-5 (2-methylphenyl... | CAS号108288-40-0 1-(溴甲基)-2-异硫代氰酰基苯 | CAS号527-85-5 2-甲基苯甲酰胺 | CAS号5262-63-5 2,4-二甲基苯并噻唑 | CAS号95-53-4 邻甲苯胺 | CAS号25372-14-9 1-(o-甲苯基)-1H-咪唑-2-硫醇 | CAS号27779-14-2 (5,6-二氢-4H-[1,3... | CAS号25717-12-8 苯并噻唑-2-基-邻甲苯-胺 | CAS号23522-37-4 4-Thiazolidinon...

O-Tolyl-Dithiocarbamic Acid ; Compound With Triethylamine置于copper(Ll) Sulfate Pentahydrate体系中,用 水,乙酸乙酯 作为反应溶剂,化学反应生成 邻甲苯异硫氰酸酯
参考文献:铜促进脱硫,合成异硫氰酸酯
标题:铜促进脱硫,合成异硫氰酸酯
摘要:在温和的反应条件下,通过一锅两步反应,将廉价,易于获得且空气稳定的催化剂用作脱硫剂,以将苯胺转化为异硫氰酸酯.
DOI:10.1016/j.Tetlet.2016.11.086

专利信息

专利号:US-7678789-B2
优先权日:2005-02-11
标 题 :[1,2,4]-dithiazoli(di)ne derivatives, inducers of gluthathione-S-transferase and NADPH quinone oxido-reductase, for prophylaxis and treatment of adverse conditions associated with cytotoxicity in general and apoptosis in particular
发明人：FEENSTRA ROELOF W; KEIZER HISKIAS G; PRAS-RAVES MARIA L; VAN VLIET BERNARD J; VAN SCHARRENBURG GUSTAAF J M
权利人:SOLVAY PHARM BV
摘要:The present invention relates to 5-imino-5H-[1,2,4]-dithiazol-3-yl-amine and [1,2,4]-dithiazolidine-3,5-diylidene-diamine derivatives as inducers of gluthathione-S-transferase (GST) and NADPH quinone oxidoreductase (NQO), to methods for the preparation of these compounds and to novel intermediates useful for the synthesis of said [1,2,4]-dithiazoli(di)ne derivatives. The invention also relates to the use of a compound disclosed herein for the treatment of adverse conditions associated with cytotoxicity in general and apoptosis in particular. The invention relates to compounds of the general formula (I): n nwhereinn nwherein the symbols have the meanings given in the specification.

专利号:US-5585487-A
优先权日:1995-05-26
标题:Method for the preparation of β-thiolactam compound
发明人：OISHI AKIHIRO; TAGUCHI YOICHI; SHIBUYA ISAO; TSUCHIYA TOHRU
权利人:AGENCY IND SCIENCE TECHN
摘要:Disclosed is a method for the preparation of a beta -thiolactam compound, i.e. a 7-substituted-2-oxa-7-azabicyclo [3.2.0]-heptan-6-thione, represented by the general formula in which R is an alkyl or aryl group, having usefulness as an intermediate for the synthesis of various biologically active compounds. The compound can be prepared by the reaction of an isothiocyanate compound R-NCS, R being the same as above, and 2,3-dihydrofuran, preferably, under pressurization up to 2000 atmospheres or higher at an elevated temperature.

专利号:EP-1851209-B1
优先权日:2005-02-11
标题:[1,2,4]-dithiazoli(di)ne derivatives, inducers of gluthathione-s-transferase and nadph quinone oxido-reductase, for prophylaxis and treatment of adverse conditions associated with cytotoxicity in general and apoptosis in particular
发明人：FEENSTRA ROELOF W; KEIZER HISKIAS G; PRAS-RAVES MARIA L; VAN VLIET BERNARD J; VAN SCHARRENBURG GUSTAAF J
权利人:ABBOTT HEALTHCARE PRODUCTS BV
摘要:The present invention relates to 5-imino-5H-[1,2,4]-dithiazol-3-yl-amine and [1,2,4]- dithiazolidine-3,5-diylidene-diamine derivatives as inducers of glutha-thione-S- transferase (GST) and NADPH quinone oxidoreductase (NQO), to methods for the preparation of these compounds and to novel intermediates useful for the synthesis of said [1,2,4]-dithiazoli(di)ne derivatives. The invention also relates to the use of a compound disclosed herein for the manufacture of a medicament useful in the for prophylaxis and treatment of adverse conditions associated with cytotoxicity in general and apoptosis in particular. The invention relates to compounds of the general formula (I): wherein the symbols have the meanings given in the specification.

专利号:US-7147856-B2
优先权日:1996-08-28
标题 :Stable radioiodine conjugates and methods of their synthesis
发明人：GOVINDAN SERENGULAM V
权利人:IMMUNOMEDICS INC
摘要:Methods are described for conjugating radioiodinated peptides or carbohydrate structures to proteins with improved yields and qualities of conjugates. In one method, specially designed radioiodinated bifunctional peptides containing nonmetabolizable amide bonds are coupled to antibodies. In a second method, radioiodinated nonmetabolizable bifunctional peptides, which also contain aminopolycarboxylates, are coupled to antibodies. In a third method, radioiodinated bifunctional aminopolycarboxylates are coupled to antibodies. In a fourth method, a hydrazide-appended antibody is coupled to a radioiodinated carbohydrate or a thiolated antibody is coupled to a hydrazide-appended and radioiodinated carbohydrate. In a fifth method a monoderivatized cyanuric chloride is used to conjugate thiolated antibody. Radioiodinated residualizing antibody conjugates made by these methods are particularly stable in vivo and are suitable for radioimmunodetection and radioimmunotherapy.

专利号:WO-0051976-A1
优先权日:1999-03-03
标 题 :Regioselective synthesis of dtpa derivatives

专利号:US-6663866-B1
优先权日:1996-08-28
标题:Stable radioiodine conjugates and methods for their synthesis
发明人：GOVINDAN SERENGULAM V
权利人:IMMUNOMEDICS INC
摘要:Methods are described for conjugating radioiodinated peptides to non-metabolizable carbohydrates with improved yields and qualities of conjugates. Radioiodinated residualizing antibody conjugates comprising a carbohydrate-appended peptide are also provided. The instant radioiodinated residualizing antibody conjugates are particularly stable in vivo and are suitable for radioimmunodetection and radioimmunotherapy.