专利号:US-10010875-B2 优先权日:2014-10-30 标题 :Method for preparing copper-zinc-based catalyst used in synthesis of methanol through CO2 hydrogenation 发明人:YU YANG; HAO AIXIANG; CHEN HAIBO; WEI SHIXIN; YIN YUSHENG; XIE TIANMING; HE JIAN; MAO CHUNPENG; TAN JIEDONG 权利人:CHINA PETROLEUM & CHEM CORP; RES INSTITUTE OF NANJING CHEMICAL INDUSTRY GR; RES INST NANJING CHEMICAL IND GROUP 摘要:Disclosed is a method for preparing a copper-zinc-based catalyst used in synthesis of methanol through CO 2 hydrogenation, and ultrasonic waves are used for control over crystalline phase's composition of a catalyst precursor. Further related to is a catalyst prepared by such a method. An amount of aurichalcite in an active catalyst precursor can be improved through the method, and the specific surface area of the metal copper in a reduced state catalyst is high. The catalyst presents high activity and hydrothermal stability, and promotes high space time yield of methanol in the synthesis of methanol through CO 2 hydrogenation.
专利号:WO-2024189634-A1 优先权日:2023-03-13 标 题 :Highly atom economical process for synthesis of novel co-initiator for photo-induced radical polymerisation 发明人:KAPAT DR AJOY; AHMAD ASRAR; MITTAL GARVISHA 权利人:SHIV NADAR INSTITUTION OF EMINENCE DEEMED TO BE UNIV 摘要:The present invention relates to a base catalyzed sequential conjugate addition reaction for the synthesis of a novel and efficient co-initiator for Photo Induced Radical Polymerization. The process comprises synthesis of new co-initiator having 6,5 and 6,6-bicyclic scaffolds as central core. The process comprises reacting thiocarboxylic acid, catechol, thiocatechol, benzodithiol, benzothiocatechol and binol with ketone substrates at room temperature with a base and a solvent to yield the novel co-initiator compound of Formula 3, Formula 5, Formula C and Formula Z.
专利号:WO-2021014395-A1 优先权日:2019-07-24 标题:Process for the synthesis of deuterated capsaicin, capsaicinoids and synthetic capsaicin analogs 发明人:ORUGANTI SRINIVAS; AMRUTAPU SRAVANTH KUMAR; SAMPATH MAGESH; SEN SAIKAT 权利人:DR REDDY’S INST OF LIFE SCIENCES 摘要:The present application provides novel processes for the synthesis of deuterated intermediates of capsaicinoids, particularly II, III, IV and V of capsaicinoids, relating to pharmaceutical applications. The invention also provides novel intermediates of compounds of formula IX, XIV, XV, XVI, XVII, XVIII, XX and XXI utilized in the process of making deuterated capsaicin II, III, IV and V.
专利号:WO-2020253243-A1 优先权日:2019-06-20 标题:Process method for catalyzed synthesis of lactide with alkali metal compound 发明人:JIANG WEI; ZHANG YANKAI; SUN PING; LI AIMIN; CHEN JINLONG; ZHANG QUANXING 权利人:NANJING UNIVERSITY OF TECHNOLOGY; NANJING QUANKAI RES INSTITUTE OF BIOMATERIALS CO LTD 摘要:The present invention provides a process method for catalyzed synthesis of lactide with an alkali metal compound, comprising: mixing an alkali metal compound with a lactic acid oligomer, and carrying out a cracking reaction to obtain lactide by means of vacuum distillation, wherein the alkali metal compound used is one or a plurality of an alkali metal carbonate, an alkali metal bicarbonate, and an alkali metal hydroxide. Compared with the prior art, the advantages of the present invention is that the alkali metal compound reacts and dissolves quickly after being added to the system avoiding the problem of pipeline blocking due to a catalyst not dissolving, the alkali metal compound used is cheap and readily available, the amount of the catalyst used is small, the yield of the reaction product lactide is greater than 80%, and the reaction is rapid and easy to industrialize.
专利号:WO-2020253244-A1 优先权日:2019-06-20 标 题 :Process for catalytic synthesis of lactide 发明人:JIANG WEI; ZHANG YANKAI; SUN PING; LI AIMIN; ZHANG QUANXING 权利人:NANJING UNIVERSITY OF TECHNOLOGY; NANJING QUANKAI RES INSTITUTE OF BIOMATERIALS CO LTD 摘要:The present invention provides a process for the catalytic synthesis of lactide, comprising: mixing a lactic acid oligomer with a composite catalyst; and synthesizing lactide under a heating condition, and collecting the product using a vacuum distillation mode. The used composite catalyst is composed of a zinc or tin compound and an alkali metal compound. Compared with the prior art, the advantages of the present invention are that: the used composite catalyst features a high production rate with a small use amount, a low reaction temperature (150-220°C), and a short reaction time (2-5 h), has a single pass yield that may reach 95% or more, reduces energy consumption compared with the prior art, and facilitates industrial implementations.
专利号:US-8350031-B2 优先权日:2008-06-02 标 题:Processes for the synthesis of levocetirizine and intermediates for use therein 发明人:RAO DHARMARAJ RAMACHANDRA; KANKAN RAJENDRA NARAYANRAO; GHAGARE MARUTI; CHIKHALIKAR SANDIP VASANT 权利人:CIPLA LTD; RAO DHARMARAJ RAMACHANDRA; KANKAN RAJENDRA NARAYANRAO; GHAGARE MARUTI; CHIKHALIKAR SANDIP VASANT 摘要:The present invention provides a compound of formula (IV) n nwherein R is Cl, Br, NO 2 , OH or OR′, and R′ is alkyl, and its use in the synthesis of levocetirizine, including its use in the synthesis of (−)-1-[(4-chlorophenyl)-phenylmethyl]piperazine, an intermediate useful in the synthesis of levocetirizine. The present invention also provides compounds (II) and (III) which are useful in the synthesis of compound (IV).
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