CAS: 520-18-3; 3,5,7-Trihydroxy-2-(4-Hydroxyphenyl)-4H-Chromen-4-One

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CAS号724434-08-6 CompoundTCFN91628 | CAS号480-10-4 紫云英苷 | CAS号23405-70-1 5,7-BIS-(BENZYL... | CAS号1098-92-6 山奈酚-5,7,4'-三甲醚 | CAS号480-20-6 二氢莰非醇； 香橙素 | CAS号482-39-3 阿福豆苷 | CAS号22688-78-4 山奈酚葡萄糖醛酸苷 | CAS号1592-70-7 异山柰素 | CAS号491-54-3 山奈素 | CAS号487-70-7 2,4,6-三羟基苯甲醛 | CAS号99-96-7 4-羟基苯甲酸 | CAS号482-38-2 山奈苷 | CAS号90-18-6 槲皮万寿菊素 | CAS号480-10-4 紫云英苷 | CAS号62369-23-7 [4-(3,5,7-trihy... | CAS号108-73-6 间苯三酚 | CAS号51-28-5 2,4-二硝基酚

Kaempferol 3-O-{[(6-O-E-P-Coumaroyl)-β-D-Glucopyranosyl(1->2)]-α-L-Rhamnopyranosyl(1->6)}-β-D-Galactopyranoside-7-O-α-L-Rhamnopyranoside置于sodium Hydroxide,维生素 C,盐酸,水体系中,用 甲醇 作为反应溶剂,化学反应 4.0H,反应生成 山奈酚
参考文献:Novel Flavonol Glycosides From The Aerial Parts Of Lentil (Lens Culinaris)
标题:Novel Flavonol Glycosides From The Aerial Parts Of Lentil (Lens Culinaris)
摘要:尽管科学文献中详细描述了小扁豆(lens Culinaris)种子的植物化学成分,但关于小扁豆叶和茎中次生代谢物的数据非常有限.我们的研究表明,小扁豆的地上部分是黄酮类化合物的丰富来源.我们分离得到了六种山柰酚和十二种槲皮素苷类,通过核磁共振波谱学和化学方法阐明了它们的结构.这一组包括16种化合物,这些化合物先前未在科学文献中被描述过:槲皮素3-O-β-D-吡喃葡萄糖基(1->2)-β-D-吡喃半乳糖苷-7-O-β-D-吡喃葡萄糖苷(1),山柰酚3-O-β-D-吡喃葡萄糖基(1->2)-β-D-吡喃半乳糖苷-7-O-β-D-吡喃葡萄糖苷(3),以及它们的衍生物4-10,12-15,17,18,这些衍生物被咖啡酸,对香豆酸,阿魏酸或3,4,5-三羟基肉桂酸酯化,以及山柰酚3-O-{[(6-O-E-对香豆酰基)-β-D-吡喃葡萄糖基(1->2)]-α-L-吡喃鼠李糖基(1->6)}-β-D-吡喃半乳糖苷-7-O-α-L-吡喃鼠李糖苷(11).我们还评估了它们的dpph自由基清除活性.这可能是关于小扁豆地上部分黄酮类化合物的首次详细描述.
DOI:10.3390/molecules191118152

专利信息

专利号:US-7816544-B2
优先权日:2004-03-23
标 题:Synthesis of rocaglamide natural products via photochemical generation of oxidopyrylium species
发明人：JONES II GUILFORD; GERARD BAUDOUIN; PORCO JR JOHN A
权利人:UNIV BOSTON
摘要:The present invention provides new strategies for the synthesis of compounds of the rocaglamide family and related natural products. In particular, the new biomimetic synthetic approach involves photochemical generation of an oxidopyrylium species from a 3-hydroxychromone derivative followed by 1,3-dipolar cycloaddition of the oxidopyrylium species to a dipolarophile. This approach can be used for the formation of adducts containing an aglain core structure. Methods for the conversion of aglain core structures to aglain, rocaglamide and forbaglin ring systems are also provided. The present invention also relates to the use of rocaglamide/aglain/forbaglin derivatives for the manufacture of medicaments for use in the treatment of cancer or cancerous conditions, disorders associated with cellular hyperproliferation, or NF-κB-dependent conditions.

专利号:WO-2025081225-A1
优先权日:2023-10-17
标 题 :Synthesis of polyphenols
发明人：TURLAND CADE LACHLAN; GROLMAN DAVID; BEHRENDORFF JAMES BRUCE YARNTON HAYCOCK; MORADI SHAYLI VARASTEH; THOMSON RAINE ELIZABETH STURT
权利人:Delica Therapeutics Pty Ltd
摘要:The present disclosure relates to polyphenols, including flavonoids, flavones and cannflavins, and methods of synthesising polyphenols. The present disclosure provides methods, enzymes and compositions that may be useful in the synthesis of polyphenols.

专利号:US-7605241-B2
优先权日:2005-01-10
标题 :Synthesis of inhibitors of p90Rsk
发明人：HECHT SIDNEY M; MALONEY DAVID J
权利人:UNIV VIRGINIA
摘要:The synthesis of the naturally occurring kaempferol glycoside SLO1O1-1, as well as analogs thereof, has been accomplished, as has its biochemical evaluation. SLO1O1-1 exhibits selective and potent p90 Rsk inhibitory activity at nanomolar concentrations without inhibiting the function of upstream kinases such as MEK, Raf, or PKC. The synthetic scheme of the invention verified the structural assignment of the natural product and has provided access to material sufficient for detailed biological evaluation.

专利号:US-5043328-A
优先权日:1986-05-09
标 题 :Formulations containing unsaturated fatty acids for the synthesis of prostaglandins and hydroxy-fatty acids in biological systems
发明人：WEITHMANN KLAUS U
权利人:HOECHST AG
摘要:The present invention relates to formulations containing unsaturated fatty acids for the synthesis of prostaglandins and hydroxy-fatty acids in biological systems and to the use of such formulations for the preparation of medicaments which are suitable for curing prostaglandin deficiencies in humans or animal, for example healing or preventing diseases of the gastro-intestinal tract.

专利号:US-2017268027-A1
优先权日:2014-12-22
标题:Method for synthesis of fatty acids
发明人：CESCUT JULIEN; URIBELARREA JEAN-LOUIS; GUILLOUET STEPHANE; MOLINA-JOUVE CAROLE; SAGNAK RANA
权利人:INST NAT DES SCIENCES APPLIQUEES DE TOULOUSE; CENTRE NAT RECH SCIENT; AGRONOMIQUE INST NAT RECH; FIDOP (FONDS DE DEV DES FILIERES DES OLEAGINEUX ET DES PROTEAGINEUX)
摘要:Disclosed is a method for synthesis of fatty acids by culturing a eukaryotic microorganism from the fungi kingdom, that is naturally oleaginous or rendered oleaginous. The culture is performed in the presence a fatty acid synthase inhibitor in the culture medium.

专利号:US-7598291-B2
优先权日:2004-09-02
标题 :Methods and compositions for enhancing collagen and proteoglycan synthesis in the skin
发明人：NIMNI MARCEL; HAN BO
权利人:NIMNI MARCEL; HAN BO
摘要:A composition for application to the skin can stimulate the in vivo synthesis of collagen and proteoglycans and improve the appearance of the skin, increasing its elasticity and fullness. In general, a composition according to the present invention comprises: (1) an antioxidant compound in a quantity sufficient to enhance collagen synthesis in the skin; (2) an organic penetrant in which the antioxidant compound is soluble in a sufficient quantity that a concentration of the antioxidant compound sufficient to enhance collagen synthesis can be applied topically and penetrate the skin; (3) a mixture of essential amino acids; (4) a supplemental source of sulfur; and (5) a topical pharmaceutically acceptable carrier. The antioxidant compound can be lipoic acid, a lipoic acid analogue or derivative, a bioflavonoid, a constituent of ginkgo, or an isoflavone. The organic penetrant is preferably benzyl alcohol. Other ingredients, such as esters of tocopherol and ascorbic acid, can be included.