CAS: 511-96-6; (2A,3B,5A,25R)-Spirostan-2,3-Diol

化学文摘社编号为511-96-6,是一个独特的识别资料,便于其在化学数据库和文献中得到承认.同许多类固醇衍生物一样,该物质的生物活动受到其结构改变的影响,能够增强其治疗潜力.

结构式图片

上下游产品

剑麻皂素 Tigogenin 77-60-1
(25R)-5A-螺甾烷-3-酮 Tigogenone 470-07-5
2α-Acetoxy-5α-Spirostan-3β-Ol 2781-69-3
(25R)-2α-Hydroxy-5α-Spirostan-3-One 848854-25-1
25D,5α-Spirostan-2α-Ol-3-On-3-Acetat 3001-32-9
龙舌兰皂苷乙酯 Hecogenin Acetate 915-35-5
Gitogenin 3-O-β-D-Glycopyranosyl(1->3)-β-D-Glucopyranoside
Trigoneoside Ib
26-O-β-D-Glucopyranosyl-(25R)-5α-Furostane-2α,3β,22ξ,26-Tetrol 3-O-β-D-Xylopyranosyl(1->4)-β-D-Glucopyranoside 290347-58-9
(25R)-2α,3β-Dihydroxy-5α-Spirostane 3-O-α-L-Rhamnopyranosyl-(1→2)-β-D-Galactopyranoside

合成工艺路线路线简述

    📜剑麻皂素置于chromium(Vi) Oxide,Cerium(Iii) Chloride Heptahydrate,硫酸,三乙胺,间氯过氧苯甲酸,Sodium Hydroxide体系中,用 四氢呋喃,甲醇,二氯甲烷,丙酮 作为反应溶剂,化学反应 4.17H,反应生成 支脱皂苷元
    参考文献:功能化 2,3-螺甾烷异构体的合成和抗真菌活性
    标题:功能化 2,3-螺甾烷异构体的合成和抗真菌活性
    摘要:侵袭性真菌感染是免疫系统受损个体的主要并发症.治疗侵袭性真菌感染的最重大挑战之一是许多生物体对广泛使用的抗真菌剂的抵抗力增加,因此开发新型抗真菌剂至关重要.许多天然产物已被发现是有效的抗微生物剂.特别是,从植物或海洋物种中分离出的含有螺甾烷糖苷部分的皂苷已被证明具有一系列抗菌特性.在这份报告中,白色念珠菌,新型隐球菌,光滑念珠菌和丝状真菌烟曲霉.
    DOI:10.1016/j.Bmcl.2011.03.092

    海关参考信息

    专利信息


    专利号:US-2025183802-A1
    优先权日:2023-11-30
    标 题 :Pulse width modulation control circuit having dual loops
    发明人:Hu kai-yu; FAN CHENG-HSUAN; CHEN YUNG-JEN; WANG CHIEN-HUI
    权利人:RICHTEK TECHNOLOGY CORP
    摘要:A pulse width modulation control circuit for controlling a power converter circuit includes: a main loop control circuit; and a light-load loop control circuit. The light-load loop control circuit includes a current synthesis circuit configured to generate a synthesized current signal according to an input voltage and a target value of an output voltage and an inductance value of an inductor in a power stage circuit of the power converter circuit. The light-load loop control circuit generates a pulse modulation signal in light-load mode according to the synthesized current signal, to control a duty ratio of the power stage circuit. In the light-load mode, the main loop control circuit enters a power-saving state to reduce the power consumption of the pulse width modulation control circuit. The power-saving state includes: reducing the power consumption of the current sense circuit or stopping the operation of the current sense circuit.

    供应商参考报价(招募中)

    品牌试剂参考报价(招募中)

    📌 第三方产品分析报告

    ✅ COA系统入驻 | 共享模式

    主要参考文献


    1: Panda S, Kar A. Corrigendum to "Role of a gitogenin-type steroidal saponin (3-O-β-d-glucopyranosyl (1→2)-β-d-glucopyranosyl (1→4)-β-d-galactopyranoside-25R, 5α-spirostane-2α,3β-diol), isolated from the leaves of Malvastrum coromandelianum in regulating thyrotoxicosis in rats" [Bioorg. Med. Chem. Lett. 26 (2016) 4804-4807]. Bioorg Med Chem Lett. 2017 May 15;27(10):2238. doi: 10.1016/j.bmcl.2017.03.048. Epub 2017 Mar 30. doi: 10.1016/j.bmcl.2016.08.025. Epub 2016 Aug 10. Erratum in: Bioorg Med Chem Lett. 2017 May 15;27(10 ):2238.

    合成参考文献


    参考文献:10.1248/cpb.6.532
    摘要:Takeda K, Okanishi T, Shimaoka A. Studies on the Steroidal Components of Domestic Plants. XVII. The Structure of Yonogenin, a New Steroidal Sapogenin from Dioscorea Tokoro MAKINO. Chem. Pharm. Bull. 1958;6(5):532–6. doi: 10.1248/cpb.6.532.
    参考文献:10.1021/ja01202a046
    摘要:MARKER RE, LOPEZ J. Steroidal sapogenins; the position of the double bond in yuccagenin and kammogenin. J Am Chem Soc. 1947 Oct;69(10):2401. doi: 10.1021/ja01202a046.
    参考文献:10.1021/ja01202a047
    摘要:MARKER RE, LOPEZ J. Steroidal sapogenins; biogenesis of the steroidal sapogenins in Agaves, Manfreda and Hesperaloe. J Am Chem Soc. 1947 Oct;69(10):2403. doi: 10.1021/ja01202a047.
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