CAS: 50735-34-7; Methyl 2-Amino-5-Bromopyridine-3-Carboxylate

相似化合物

335031-01-1 52833-94-0 206997-15-1

上下游产品

CAS号52833-94-0 2-氨基-5-溴烟酸 | CAS号18107-18-1 (三甲硅烷)重氮甲烷

2-氨基烟酸置于硫酸,溴,溶剂黄146体系中,化学反应 38.0H,反应生成 2-氨基-5-溴烟酸甲酯
参考文献:Dyrk1A抑制剂的多种杂环双酚化合物的合成及体外评价
标题:Dyrk1A抑制剂的多种杂环双酚化合物的合成及体外评价
摘要:双特异性酪氨酸磷酸化相关激酶1A(dyrk1A)是一种双特异性蛋白激酶,可催化磷酸化和自身磷酸化.较高的dyrk1A表达与癌症有关,特别是与脑内存在的胶质母细胞瘤有关.我们在这里报告设计为新型dyrk1A抑制剂的新型杂环二酚衍生物的合成和生物学评估.根据dandy铅的结构修饰,制备了这些杂环,如苯并咪唑,咪唑,萘啶,吡唑-吡啶,联吡啶和三唑并吡嗪,并测试了它们抑制dyrk1A的能力.这些衍生物均未显示出明显的dyrk1A抑制作用,但提供了有关7-氮杂吲哚部分重要性的有价值的知识.
DOI:10.1016/j.Bmc.2018.10.034

专利信息

专利号:WO-2023081730-A1
优先权日:2021-11-03
标 题:4-hydroxy-2-oxo-1,2-dihydro-1,8-naphthyridine-3-carboxamide derivatives as cannabinoid cb2 receptor modulators for the treatment of cancer
发明人：ELZEIN ELFATIH; LIU JIWEN
权利人:TEON THERAPEUTICS INC
摘要:The present invention relates to 82 specific 4-hydroxy-2-oxo-1,2- dihydro-1,8-naphthyridine-3-carboxamide derivatives as cannabinoid CB2 receptor modulators for the treatment of cancer, e.g. to 6-(4- fluorophenyl)-4-hydroxy-1-(2-(4-methylpiperazin-1-yl)ethyl)-2-oxo-N- (spiro[2.3]hexan-5-yl)-1,2-dihydro-1,8-naphthyridine-3-carboxamide (example 1, compound 1) The present description discloses the synthesis and characterisation of the 82 claimed compounds as well as biological assays thereof.

专利号:US-9682966-B2
优先权日:2012-08-16
标 题 :Kappa opioid ligands
发明人：ROBERTS EDWARD; GUERRERO MIGUEL A; URBANO MARIANGELA; ROSEN HUGH
权利人:SCRIPPS RESEARCH INST
摘要:The invention provides novel ligands of Kappa (κ) opioid receptors, such as can be used to modulate a Kappa opioid receptor. Methods of synthesis and methods of use are also provided. Compounds of the invention can be used therapeutically in the treatment of dissociative disorders or pain, or to provide neuroprotection, or to induce diuresis, or to modulate the immune system, or for treatment of one or more of an affective disorders comprising depression or stress/anxiety; an addictive disorder; alcoholism, epilepsy; a cognition deficiency; schizophrenia; Alzheimer's disease; or pain.

专利号:CN-113235116-B
优先权日:2021-05-12
标题 :A kind of electrochemical synthesis method of bromopyridine derivatives

专利号:CN-113235116-A
优先权日:2021-05-12
标题 :A kind of electrochemical synthesis method of bromopyridine derivative