CAS: 498-45-3; (1R,2R,4S,5S,7S)-9-Methyl-3-Oxa-9-Azatricyclo[3.3.1.02,4]Nonan-7-Ol

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CAS号51-34-3 东莨菪碱 | CAS号1121-63-7 cyclohepta-3,5-... | CAS号115522-58-2 6-(benzyloxy)-1... | CAS号132622-29-8 1β-hydroxy-4β-c... | CAS号115522-57-1 1β-acetoxy-4β-c... | CAS号132622-34-5 pseudoscopine b... | CAS号139404-48-1 噻托溴铵 | CAS号136310-64-0 2-(2-噻吩基)乙醇酸东莨菪酯

专利信息

专利号:WO-2013046138-A1
优先权日:2011-09-27
标 题:Process for the preparation of scopine esters
发明人：CIPOLLONE AMALIA; FATTORI DANIELA; FINCHAM CHRISTOFER INGO
权利人:LUSOCHIMICA SPA
摘要:The present invention relates to a process for the preparation of scopine esters, as intermediates in the synthesis of tiotropium bromide. In particular, it relates to a transesterification process between scopine alcohol and an ester of a carboxyl acid in high yields and under conditions suitable for industrial use.

专利号:US-9994572-B2
优先权日:2015-09-04
标题 :Therapeutic compounds for pain and synthesis thereof
发明人：DECORTE BART; RUSSCHER JACOB CORNELIS; MONNEE MENNO CORNELIS FRANCISCUS
权利人:JANSSEN PHARMACEUTICA NV
摘要:The invention provides compounds of Formula 1: n nand stereoisomers, pharmaceutically acceptable salts and derivatives thereof; and methods of making and using such compounds. The invention includes pharmaceutical compositions containing such compounds, and the use of such compounds in methods of treating conditions, diseases, or disorders.

专利号:CY-1117612-T1
优先权日:2012-03-30
标题:A METHOD FOR THE PREPARATION OF THE DETERMINATED ESTE OF DY- (2-THYNYLYL) GLUCIC ACID, AN INTERMEDIATE UNION IN THE SYNTHESIS OF BROOM

专利号:US-9440945-B2
优先权日:2010-04-01
标 题 :Methods for the synthesis of tiotropium bromide
发明人：BILGIC MAHMUT
权利人:BILGIC MAHMUT
摘要:Present invention relates to methods for preparing (1α, 2β, 4β, 5α, 7β)-7-[(hydroxidi-2-thienllacetyl)oxy]-9,9-dimethyl-3-oxa-9-azoniatricyclo[3.3.1.0 2,4 ]nonane-bromide.

专利号:WO-2013135219-A1
优先权日:2012-03-16
标 题 :A method of preparing the scopine ester of di-(2-thienyl)glycolic acid, an intermediate in the synthesis of tiotropium bromide, and its new form

专利号:EP-2825535-A1
优先权日:2012-03-16
标题:A method of preparing the scopine ester of di-(2-thienyl)glycolic acid, an intermediate in the synthesis of tiotropium bromide, and its new form