CAS: 37234-97-2; µ-[(1,2-?:3,4-?)-Copper(I) Trifluoromethanesulfonate Benzene Complex

📜Copper(II) Bis(Trifluoromethanesulfonate)置于pb(C2H5)4体系中,用 溶剂黄146 作为反应溶剂,化学反应生成 三氟甲烷磺酸亚铜(I)苯联合体 (2:1)
参考文献:二.四乙基铅还原铜(II).乙酸中乙基的证据
标题:二.四乙基铅还原铜(II).乙酸中乙基的证据
摘要:乙酸铜,三氟甲磺酸盐和氯化铜很容易在乙酸溶液中被四乙基铅还原成亚铜盐.随后将亚铜盐参与前述的催化过程,以通过乙酰化更多的四乙基铅来生产乙烷.还原步骤的化学计量要求对于每个产生的乙酸三乙基铅消耗两个cu Ii.在该方法中释放的乙基可以定量地解释为乙烯,乙酸乙酯或氯乙烷.后者与通过相同的cu Ii配合物氧化独立产生的乙基所得的产物相同.cu Ii的还原建议通过从四乙基铅进行烷基转移来形成亚稳的乙基铜(II)中间体,然后进行快速均相分解.释放的乙基被cu Ii有效清除.讨论了这些有机铜(II)中间体与先前通过非质子介质中各种其他烷基化剂将cu Ii烷基化而反应生成的中间体的关系.
DOI:10.1016/s0022-328X(00)81850-1

专利信息

专利号:US-11479577-B2
优先权日:2016-05-18
标题:Intermediates for the synthesis of bile acid derivatives, in particular of obeticholic acid
发明人：WEYMOUTH-WILSON ALEXANDER; KOMSTA ZOFIA; WALLIS LAURA; EVANS TIMOTHY; DAVIES IEUAN; OTTER CARL; BATCHELOR RHYS
权利人:NZP UK LTD
摘要:The present invention relates to compounds which are intermediates in the synthesis of bile acid derivatives with pharmacological activity. The invention relates to compounds of general formula (I):wherein:, R1, R2, R3, R4, R5, R6 and Y are as defined herein.The compounds are intermediates in the synthesis of synthetic bile acids which are useful in the treatment of conditions such as liver disease. In addition, the invention relates to a method of synthesizing these intermediates and a method of preparing obeticholic acid and obeticholic acid analogues from the compounds of the invention.

专利号:EP-2280974-B1
优先权日:2008-04-30
标题:Stereoselective synthesis of certain trifluoromethyl-substituted alcohols
发明人：REEVES JONATHAN TIMOTHY; SONG JINHUA J; TAN ZHULIN
权利人:BOEHRINGER INGELHEIM INT; BOEHRINGER INGELHEIM PHARMA
摘要:A process for stereoselective synthesis of a compound of Formula (I) wherein R1, R2, R3, R4, and R5 are as described herein.

专利号:US-10053415-B2
优先权日:2016-01-20
标题:Synthesis of a substituted indene derivative
发明人：HARWIG CURTIS; SEENISAMY JEYAPRAKASHNARAYANAN; KEREGADDE MAHESH NARAYAN; CHETIA LAKSHINDRA
权利人:AQUINOX PHARMACEUTICALS CANADA INC
摘要:This invention is directed to methods of preparing AQX-1125 having the formula: n n n n n n n n n n This invention is also directed to intermediates utilized in the methods of preparing AQX-1125.

专利号:US-9045462-B2
优先权日:2012-08-17
标 题 :Synthesis of an antiviral compound
发明人：EVANS JARED WAYNE; FUJIMORI SHINJI; HUYNH GRACE M; LIU QI; TERESK MARTIN GERALD
权利人:GILEAD SCIENCES INC
摘要:The present disclosure provides processes for the preparation of a compound of Formula I: n nwhich is useful as an antiviral agent. The disclosure also provides compounds that are synthetic intermediates to compounds of formula.

专利号:US-2022056025-A1
优先权日:2018-09-25
标 题:Synthesis of pyrido[2,3-d]pyrimidin-7(8h)-ones
发明人：BROWN ADAM ROSS; DESROSIERS JEAN-NICOLAS; DUAN SHENGQUAN; HAWKINS JOEL MICHAEL; HAYWARD CHERYL MYERS; MALONEY MARK THOMAS; MONFETTE SEBASTIEN; PERFECT HAHDI HAKIMIOUN; WIDLICKA DANIEL WILLIAM
权利人:PFIZER
摘要:This invention relates to novel methods to prepare substituted pyrido[2,3-d]pyrimidin-7(8H)-ones, and salts and stereoisomers thereof, as well as intermediates useful for the preparation of such compounds.

专利号:US-8927741-B2
优先权日:2012-08-17
标 题 :Synthesis of an antiviral compound
发明人：WATKINS WILLIAM JOHN; LIU QI
权利人:GILEAD SCIENCES INC
摘要:The present disclosure provides a processes for the preparation of a compound of Formula I: n nwhich is useful as an antiviral agent. The disclosure also provides compounds that are synthetic intermediates to compounds of Formula I.