CAS: 3430-13-5; 5-Bromo-2-Methylpyridine

相似化合物

38749-87-0 38749-79-0 3430-31-7

上下游产品

5-Amino-2-methylpyridine picoline hydr°Chloride α-picoline 6-methylnicotinamide 5-bromoisonicotinic acid (5-benzyloxy-2-methoxyphenyl)-(6-methylpyridin-3-yl)methanol 5-bromo-2-methyl-pyridine-N-oxide ethynyl>-benzoateethyl 4-4-(6-methyl-pyridin-3-yl)-2,2-dimethyl-(2H)-thi°Chromen-6-ylethynyl-benzoate

6-甲基-3-吡啶羰基叠氮化物置于氢氧化钾,Potassium Nitrite,硫酸体系中,化学反应生成 5-溴-2-甲基吡啶
参考文献:Graf,Journal Fur Praktische Chemie (Leipzig 1954),1932,Vol. <2> 133,P. 36,49
标题:Graf,Journal Fur Praktische Chemie (Leipzig 1954),1932,Vol. <2> 133,P. 36,49

专利信息

专利号:EP-1853592-B1
优先权日:2005-01-14
标题:Synthesis of himbacine analogs
发明人：THIRUVENGADAM TIRUVETTIPURAM K; WANG TAO; LIAO JING; CHIU JOHN S; TSAI DAVID J S; LEE HONG-CHANG; WU WENXUE; FU XIAOYONG
权利人:SCHERING CORP
摘要:The present invention relates to an improved process for preparing imbacine analogs. The compounds are useful as thrombin receptor antagonists. The improved process may allow for at least one of easier purification by crystallization, easier scalability, and improved process yield on the desired enantiomer. An example of a step in the synthesis of such a himbacine analog is as follows: Formula (I)

专利号:US-6635767-B2
优先权日:2000-05-23
标 题 :Synthesis of heteroarylamine intermediate compounds
发明人：SONG JINHUA J; YEE NATHAN K; KAPADIA SURESH R
权利人:BOEHRINGER INGELHEIM PHARMA
摘要:Disclosed are novel 2-(5-halopyridyl) and 2-(5-halopyrimidinyl) magnesium halides, processes of making and their use in the efficient synthesis in their respective 5-halo-2-substituted pyridines and pyrimidines.

专利号:US-6822093-B2
优先权日:2000-05-23
标题 :Synthesis of heteroarylamine intermediate compounds
发明人：SONG JINHUA J; YEE NATHAN K
权利人:BOEHRINGER INGELHEIM PHARMA
摘要:Disclosed are novel 2-(5-halopyridyl) and 2-(5-halopyrimidinyl) magnesium halides, processes of making and their use in the efficient synthesis in their respective 5-halo-2-substituted pyridines and pyrimidines.

专利号:US-8329905-B2
优先权日:2006-06-30
标 题 :Synthesis of diethyl{[5-(3-fluorophenyl)-pyridine-2yl]methyl}phosphonate
发明人：YONG KELVIN H; ZAVIALOV ILIA A; YIN JIANGUO; FU XIAOYONG; THIRUVENGADAM THIRUVETTIPURAM K
权利人:YONG KELVIN H; ZAVIALOV ILIA A; YIN JIANGUO; FU XIAOYONG; THIRUVENGADAM THIRUVETTIPURAM K; MERCK SHARP & DOHME
摘要:This application discloses a novel process for the preparation of phosphonate esters useful as intermediates in the preparation of himbacine analogs, themselves useful as thrombin receptor antagonists. The chemistry taught herein can be exemplified by the following scheme: n nwherein R 9 is selected from alkyl, aryl heteroaryl and arylalkyl groups having 1 to 10 carbon atoms, and R 11 is selected independently for each occurrence from alkyl, aryl heteroaryl and arylalkyl groups having 1 to 10 carbon atoms and hydrogen, X 2 is Cl, Br, or I; X 3 is selected from Cl and Br; and PdL n is a supported palladium metal catalyst or a soluble heterogeneous palladium catalyst. The L-derivatizing reagent is a moiety which converts the alcohol functional group of compound 137D to any leaving group which can be displaced by a triorgano-phosphite phosphonating agent.

专利号:US-12319691-B2
优先权日:2020-05-04
标题 :Heterocyclic compounds as triggering receptor expressed on myeloid cells 2 agonists and methods of use
发明人：CZABANIUK LARA C; HOPPER TIMOTHY; HOUZE JONATHAN B; RESCOURIO GWENAELLA; SANTORA VINCENT; WANG HAOXUAN; WHITE RYAN D; WONG ALICE R; WU YONGWEI
权利人:AMGEN INC; VIGIL NEUROSCIENCE INC
摘要:The present disclosure provides compounds of Formula I, useful for the activation of Triggering Receptor Expressed on Myeloid Cells 2 (“TREM2â€?).This disclosure also provides pharmaceutical compositions comprising the compounds, uses of the compounds, and compositions for treatment of, for example, a neurodegenerative disorder. Further, the disclosure provides intermediates useful in the synthesis of compounds of Formula I.

专利号:US-7884125-B2
优先权日:2008-04-30
标 题:Straightforward entry to 7-azabicyclo[2.2.1]heptane-1-carbonitriles and subsequent synthesis of epibatidine analogues
发明人：STEVENS CHRISTIAN; HEUGEBAERT THOMAS
权利人:UNIV GENT
摘要:The present invention relates to a group of substituted-7-azabicyclo-[2.2.1]heptyl derivatives with biological activity. The present invention also relates to synthetic methods for producing said substituted-7-azabicyclo-[2.2.1]heptyl derivatives. The present invention also relates to certain intermediates for producing such substituted-7-azabicyclo-[2.2.1]heptyl derivatives, as well as a synthetic method for producing such intermediates. The present invention also relates to pharmaceutical compositions comprising such substituted-7-azabicyclo-[2.2.1]heptyl derivatives, as well as their use as medicaments for the treatment of diseases mediated by a Nicotinic Acetylcholine Receptor or a receptor being a member of the Neurotransmitter-gated Ion Channel Superfamily, such as pain, Alzheimer's disease, Parkinson's disease, schizophrenia, epilepsy and nicotine addiction.