CAS: 234108-73-7; Tert-Butyl 2-Chloropyridine-4-Carbamate

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CAS号14432-12-3 4-氨基-2-氯吡啶 | CAS号24424-99-5 二碳酸二叔丁酯 | CAS号73583-37-6 4-溴-2-氯吡啶 | CAS号4248-19-5 氨基甲酸叔丁酯 | CAS号762-75-4 甲酸叔丁酯 | CAS号234108-74-8 (2-氯-3-碘-4-吡啶)氨... | CAS号893423-62-6 N-(2-氯-3-甲酰基-4-... | CAS号1190198-21-0 3-碘-2-甲氧基吡啶-4-胺 | CAS号887831-85-8 (2-氯-4-吡啶)甲基 氨基...

📜2-氯-4-氨基吡啶,甲酸叔丁酯置于sodium Hexamethyldisilazane体系中,用 四氢呋喃 用作溶剂,化学反应 4.0H,以5.57 G的收率获得(4-吡啶基)氨基甲酸叔丁酯
参考文献:Discovery Of An Orally Efficacious Inhibitor Of Coagulation Factor Xa Which Incorporates A Neutral P1 Ligand
标题:Discovery Of An Orally Efficacious Inhibitor Of Coagulation Factor Xa Which Incorporates A Neutral P1 Ligand
摘要:The Discovery And Sar Of Ketopiperazino Methylazaindole Factor Xa Inhibitors Are Described. Structureactivity Data Suggesting That This Class Of Inhibitors Does Not Bind In The Canonical Mode Were Confirmed By An X-Ray Crystal Structure Showing The Neutral Haloaromatic Bound In The S,Subsite. The Most Potent Azaindole,33 (Rpr209685),Is Selective Against Related Serine Proteases And Attains Higher Levels Of Exposure Upon Oral Dosing Than Comparable Benzamidines And Benzamidine Isosteres. Compound 33 Was Efficacious In The Canine Av Model Of Thrombosis.
Doi:10.1021/jm020384Z