CAS: 2050-48-8; 4,4'-Sulfonylbis(Bromobenzene)

该化合物是一种多用途有机化合物,具有独特的溴化芳烃磺酰胺结构,具有极好的热稳定性和化学抗药性,适合各种用途.该化合物的溴化替代成分提高了有机溶剂的溶性,促进了有机反应合成.其特性使它成为特殊化学品和药品生产中有价值的中间体.

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合成工艺路线路线简述

    📜氨苯砜置于硫酸,Copper(I) Bromide,Sodium Nitrite体系中,化学反应生成4,4'-二溴二苯砜
    参考文献:Brinon,M.C.; Bertorello,M.M. De; Bertorello,H.E.,Bulletin Des Societes Chimiques Belges,1987,Vol. 96,# 1,P. 41-50
    标题:Brinon,M.C.; Bertorello,M.M. De; Bertorello,H.E.,Bulletin Des Societes Chimiques Belges,1987,Vol. 96,# 1,P. 41-50

    海关参考信息

    专利信息


    专利号:US-7531694-B2
    优先权日:2004-07-07
    标题:Process for synthesis of 4-4′-diamino-diphenyl-sulfone
    发明人:VILLA MARCO; DE FAVERI CARLA; ZANOTTI RICCARDO; CIARDELLA FRANCESCO; BORIN FABRIZIO
    权利人:LUNDBECK PHARMACEUTICALS ITALY
    摘要:A new process for the preparation and purification of 4-4′-diamino-diphenyl-sulfone (dapsone) is described. The process described is a three step process comprising a condensation reaction with the synthesis of a thioether intermediate and then steps of oxidation and reduction in suitable conditions in order to obtain a product with good yield and purity.

    专利号:US-2008293970-A1
    优先权日:2004-07-07
    标 题:Process for Synthesis of 4-4'-Diamino-Diphenyl-Sulfone

    专利号:WO-2006002690-A1
    优先权日:2004-07-07
    标 题 :Process for synthesis of 4-4'-diamino-diphenyl-sulfone

    专利号:KR-20210043801-A
    优先权日:2019-10-11
    标 题 :Synthesis of Sulfones and Sulfonyl Derivatives using Sodium (tert-butyldimethylsilyl)oxymethanesulfinate

    专利号:EP-1778630-B1
    优先权日:2004-07-07
    标题 :Process for synthesis of 4-4'-diamino-diphenyl-sulfone

    专利号:CA-2573114-C
    优先权日:2004-07-07
    标题:Process for synthesis of 4-4'-diamino-diphenyl-sulfone

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    合成参考文献


    摘要:U.S. Army Armament Research & Development Command, Chemical Systems Laboratory, NIOSH Exchange Chemicals., NX#01239
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