CAS: 20274-89-9; Glycylglycyl-L-Valine

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1963-21-9 10521-49-0 14857-82-0

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CAS号29022-11-5 Fm°C-甘氨酸

Fmoc-甘氨酸,Alkaline Earth Salt Of/the/ Methylsulfuric Acid 反应生成甘氨酰-甘氨酰-L-缬氨酸
参考文献:使用双量子偶极耦合固态核磁共振光谱法测定肽骨架扭转角
标题:使用双量子偶极耦合固态核磁共振光谱法测定肽骨架扭转角
摘要:已经开发了几种利用偶极耦合固态核磁共振 (SsNMR) 技术在肽和蛋白质中以高分辨率确定局部结构的方法.然而,这些技术中的许多技术仅测量一个扭转角或仅对某些类别的二级结构是准确的.此外,这些偶极再耦合实验在高磁场强度下抑制化学位移各向异性 (Csa) 有害影响的效率各不相同.与无窗序列 (Draws) 的偶极耦合已被证明是一种有效的脉冲序列,可用于激发沿肽骨架的相邻羰基碳之间的双量子 (Dq) 相干性.通过允许这种 Dq 一致性发展,可以测量 Csa 张量的相对方向,然后使用此信息来确定拉马钱德兰扭转角 Phi 和 Psi.在这里,我们探讨了在解释 Dq-Draws 数据时所做假设的准确性,并证明了它们在测量对应于各种二级结构的扭转角时的保真度,而不管氢键模式如何.展示了如何简单地选择同位素标记和实验条件,无需任何先验知识即可准确测量主链二级结构.这种方法对于确定螺旋结构更加敏感,并且与其
Doi:10.1021/ja074244W

专利信息

专利号:US-2003049619-A1
优先权日:2001-03-21
标题 :Methods for the synthesis of polynucleotides and combinatorial libraries of polynucleotides
发明人：DELAGRAVE SIMON; MARRS BARRY
摘要:Methods for the synthesis of polynucleotides and derivatives thereof are provided. Methods for the preparation of combinatorial libraries of polynucleotides are also provided. In addition, methods for the preparation and identification of polynucleotides having a predetermined property are provided.

专利号:US-6593459-B1
优先权日:1998-06-16
标题:Synthetic glycosulfopeptides and methods of synthesis thereof
发明人：CUMMINGS RICHARD D; MCEVER RODGER P
权利人:UNIV OKLAHOMA
摘要:A new class of synthetic glycosulfopeptides (GSPs) which have one or more sulfated tyrosine residues and a glycan linked to the peptide, the glycan preferably including a sialyl Lewis x group or a sialyl Lewis a group. In a preferred version the GSPs have an O-glycan comprising a β1,6 linkage to a GalNAc. The present invention further contemplates in vitro methods of the synthesis of these GSPs without the use of the cells and methods of their use in vivo as powerful anti-inflammatory antithrombotic, or anti-metastatic compounds. The invention also contemplates a method of synthesizing oligosaccharides by cleaving the glycan from the GSP.

专利号:US-2004053274-A1
优先权日:2002-09-04
标 题 :Gene cluster of vicenistatin biosynthesis, a vicenisamine glycosyltransferase polypeptide, and a gene encoding the polypeptide
发明人：KAKINUMA KATSUMI
权利人:TOKYO INST TECH
摘要:To achieve enzymatic production of vicenistatin, a valuable compound, this invention provides enzymes involved in biosynthesis of vicenistatin and genes encoding the enzymes. This invention provides base sequence of the vin cluster which encodes enzyme complex responsible for biosynthesis of vicenistatin. This invention further provides a glycosyltransferase (VinC enzyme), which catalyzes production of vicenistatin using dTDP-vicenisamine as a substrate. Moreover, this invention provides a gene (vinC gene) encoding the enzyme. The VinC enzyme is useful for enzymatic synthesis of valuable compound vicenistatin. Furthermore, it is suggested that use of the VinC enzyme will enable development of novel polyketide glycosides.

专利号:US-2003157592-A1
优先权日:1999-12-16
标题:Moss genes from physcomitrella patens encoding proteins involved in the synthesis of tocopherols and carotenoids
发明人：LERCHL JENS; RENZ ANDREAS; EHRHARDT THOMAS; REINDL ANDREAS; CIRPUS PETRA; BISCHOFF FRIEDRICH; FRANK MARKUS; FREUND ANNETTE; DUWENIG ELKE; SCHMIDT RALF-MICHAEL; RESKI RALF; BADUR RALF
摘要:Isolated nucleic acid molecules, designated TCMRP nucleic acid molecules, which encode novel TCMRPs from e.g. Phycomitrella patens are described. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing TCMRP nucleic acid molecules, and host cells into which the expression vectors have been introduced. The invention still further provides isolated TCMRPs, mutated TCMRPs, fusion proteins, antigenic peptides and methods for the improvement of production of a desired compound from transformed cells, organisms or plants based on genetic engineering of TCMRP genes in these organisms.

专利号:US-6075183-A
优先权日:1997-04-11
标 题:Methods and compositions for synthesis of long chain poly-unsaturated fatty acids in plants
发明人：KNUTZON DEBORAH; MUKERJI PRADIP; HUANG YUNG-SHENG; THURMOND JENNIFER; CHAUDHARY SUNITA
权利人:ABBOTT LAB; CALGENE LLC
摘要:The present invention relates to compositions and methods for preparing poly-unsaturated long chain fatty acids in plants, plant parts and plant cells, such as leaves, roots, fruits and seeds. Nucleic acid sequences and constructs encoding fatty acid desaturases, including Δ5-desaturases, Δ6-desaturases and Δ12-desaturases, are used to generate transgenic plants, plant parts and cells which contain and express one or more transgenes encoding one or more desaturases. Expression of the desaturases with different substrate specificities in the plant system permit the large scale production of poly-unsaturated long chain fatty acids such as docosahexaenoic acid, eicosapentaenoic acid, α-linoleic acid, gamma-linolenic acid, arachidonic acid and the like for modification of the fatty acid profile of plants, plant parts and tissues. Manipulation of the fatty acid profiles allows for the production of commercial quantities of novel plant oils and products.

专利号:US-6004787-A
优先权日:1991-01-17
标题:Method of directing biosynthesis of specific polyketides
发明人：KATZ LEONARD; DONADIO STEFANO; MCALPINE JAMES B
权利人:ABBOTT LAB
摘要:A method to produce novel polyketide structures by designing and introducing specified changes in the DNA governing the synthesis of the polyketide is disclosed. The biosynthesis of specific polyketide analogs is accomplished by genetic manipulation of a polyketide-producing microorganism by isolating a polyketide biosynthetic gene-containing DNA sequence, identifying enzymatic activities associated within the DNA sequence, introducing one or more specified changes into the DNA sequence which codes for one of the enzymatic activities which results in an altered DNA sequence, introducing the altered DNA sequence into the polyketide-producing microorganism to replace the original sequence, growing a culture of the altered microorganism under conditions suitable for the formation of the specific polyketide analog, and isolating the specific polyketide analog from the culture. The method is most useful when the segment of the chromosome modified is involved in an enzymatic activity associated with polyketide biosynthesis, particularly for manipulating polyketide synthase genes from Saccarharopolyspora or Streptomyces.