CAS: 1975-51-5; 2-Methyl-4-Nitrobenzoic Acid

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CAS号99584-16-4 2-methyl-4-nitr... | CAS号89001-53-6 2-甲基-4-硝基苯腈 | CAS号2486-75-1 4-氨基-2-甲基苯甲酸 | CAS号99-52-5 2-甲基-4-硝基苯胺 | CAS号99-51-4 4-硝基邻二甲苯 | CAS号7697-37-2 硝酸 | CAS号7647-01-0 盐酸 | CAS号64-19-7 冰醋酸 | CAS号30459-70-2 2-甲基-4-硝基苯甲酰氯 | CAS号222036-66-0 5-氨基-2,3-二氢异吲哚-... | CAS号62621-09-4 2-甲基-4-硝基苯甲酸甲酯 | CAS号578-39-2 4-羟基-2-甲基苯甲酸 | CAS号99-08-1 3-硝基甲苯 | CAS号137982-91-3 7-氯-1,2,3,4-四氢-... | CAS号137977-97-0 1-(4-氨基-2-甲基苯甲酰... | CAS号137973-76-3 N-[4-[(7-氯-2,3,... | CAS号150683-30-0 托伐普坦 | CAS号133446-99-8 2-(溴甲基)-4-硝基苯甲酸甲酯

4-硝基-2-甲苯胺置于盐酸,硫酸,Sodium Nitrite体系中,化学反应 21.25H,反应生成2-甲基-4-硝基苯甲酸
参考文献:具有旋转受限的谷氨酸或鸟氨酸侧链的5-脱氮叶酸酯类似物:与叶酰聚谷氨酸合成酶的合成和结合相互作用.
标题:具有旋转受限的谷氨酸或鸟氨酸侧链的5-脱氮叶酸酯类似物:与叶酰聚谷氨酸合成酶的合成和结合相互作用.
摘要:5-脱氮杂戊酰基-L-谷氨酸和(6R,6S)-5-Deaza-5,6,7,8-四氢蝶酰基-L-谷氨酸的旋转受限类似物,在酰胺氮和6'-之间具有一碳桥合成了对氨基苯甲酰基部分的位置并作为叶酸聚谷氨酸合成酶(fpgs)的底物进行了测试,叶酸是谷氨酸代谢中的关键酶,是经典抗叶酸药物治疗效果和选择性的重要决定因素.还合成了相应的5-脱氮杂戊酰基-L-鸟氨酸和(6R,6S)-5-Deaza-5,6,7,8-四氢蝶酰基-L-鸟氨酸的桥接类似物作为潜在的抑制剂.L-谷氨酸二乙酯与2-溴甲基-4-硝基苯甲酸甲酯缩合,然后催化还原硝基,与2-乙酰氨基-6-甲酰基吡啶基还原偶合[2,3-D]嘧啶-4(3H)-在二甲基氨基硼烷存在下,用hbr / Acoh酸解生成2-L-[5-[n-(2-乙酰氨基-4(3H)-氧吡咯并] [2,3-D]嘧啶-6-基)甲氨基]-2,3-二氢-1-氧代-2(1H)-异吲哚基
Doi:10.1021/jm9807205

专利信息

专利号:US-9840468-B1
优先权日:2016-12-30
标 题:Methods for the preparation of 6-aminoisoquinoline
发明人：CHAMBOURNIER GILLES; DELONG MITCHELL A
权利人:AERIE PHARMACEUTICALS INC
摘要:Described are methods for the preparation of 6-aminoisoquinoline, a useful intermediate compound in the synthesis of kinase inhibitors.

专利号:WO-2021249877-A1
优先权日:2020-06-08
标 题 :Intermediates and processes for the preparation of tolvaptan and its derivatives
发明人：VIGO DANIELE; CAPUTO FRANCESCO; COLOMBO FRANCESCO
权利人:CAMBREX PROFARMACO MILANO S R L
摘要:The present invention relates to new intermediates for the synthesis of Tolvaptan and of its derivatives and a process for its preparation involving said intermediates.

专利号:US-10766863-B2
优先权日:2014-11-17
标 题 :Monocarboxylate transport modulators and uses thereof
发明人：SANDANAYAKA VINCENT; WU QIONG
权利人:NIROGYONE THERAPEUTICS INC
摘要:The invention generally relates to the field of monocarboxylate transport modulators, e.g., monocarboxylate transport inhibitors, and more particularly to new substituted-quinolone compounds, the synthesis and use of these compounds and their pharmaceutical compositions, e.g., in treating, modulating, forestalling and/or reducing physiological conditions associated with monocarboxylate transport activity such as in treating cancer and other neoplastic disorders, inflammatory diseases, disorders of abnormal tissue growth and fibrosis including cardiomyopathy, obesity, diabetes, cardiovascular diseases, tissue and organ transplant rejection, and malaria.

专利号:RU-2194046-C2
优先权日:1997-05-23
标 题:Novel nitromethylketones, method of their synthesis and compositions comprising thereof