CAS: 186508-95-2; Tert-Butyl 2-((4S,6R)-6-(Cyanomethyl)-2,2-Dimethyl-1,3-Dioxan-4-yl)Acetate

相似化合物

124752-23-4 196085-85-5 196085-84-4

上下游产品

2,2-dimethoxy-propane tert-butyl [(4S,6R)-6-(2-aminoethyl)-2,2-dimethyl-1,3-dioxane-4-yl]acetate

📜(5R)-Tert-Butyl-6-Cyano-3,5-Dihydroxyhexanoate,2,2-二甲氧基丙烷置于4-Methylbenzene-1-Sulfonic Acid Monohydrate体系中,用 丙酮 用作溶剂,化学反应 1.0H,以71%的收率获得(4S,6R)-6-(氰基甲基)-2,2-二甲基-1,3-二恶烷-4-乙酸叔-丁酯
参考文献:Synthesis Of Some Impurities And/or Degradation Products Of Atorvastatin
标题:Synthesis Of Some Impurities And/or Degradation Products Of Atorvastatin
摘要:阐述了阿托伐他汀钙(3R,5R)-7-[2-(4-氟苯基)-5-异丙基-3-苯基-4-(苯基甲酰氨基)吡咯-1-基]-3,5-二羟基庚酸的一些杂质和/或降解产物的合成.这些包括其去氟类似物,相应的(3S,5S)-和(3S,5R)-对映体,阿托伐他汀内酯和一些其他潜在杂质.合成的化合物以及相应的中间体通过1H NMR,13C NMR和ms进行了表征.
Doi:10.1135/cccc20080229

专利信息

专利号:US-7232915-B2
优先权日:1997-12-19
标题:Process for the synthesis of 1,3-diols
发明人：BOSCH ROBERT LEE; MCCABE RICHARD JOSEPH; NANNINGA THOMAS NORMAN; STAHL ROBERT JOSEPH
权利人:WARNER LAMBERT CO
摘要:An improved process for the preparation of cis-1,3-diols is described where a beta hydroxy ketone is treated with a trialkylborane or dialkylalkoxyborane or a mixture of a trialkylborane and a dialkylalkoxyborane followed by recovery and reuse of the alkylborane species to convert additional beta hydroxy ketone to the cis-1,3-diol.

专利号:US-2002161021-A1
优先权日:1997-12-19
标 题:Process for the synthesis of 1,3-diols

专利号:US-2004006231-A1
优先权日:1997-12-19
标题:Process for the synthesis of 1,3-diols

专利号:US-2005197500-A1
优先权日:1997-12-19
标 题 :Process for the synthesis of 1,3-diols

专利号:EP-1054860-B1
优先权日:1997-12-19
标 题 :Process for the synthesis of 1,3-diols

专利号:US-6596879-B2
优先权日:1997-12-19
标题 :Process for the synthesis of 1,3-diols