CAS: 183438-24-6; 5-Bromo-2-Iodopyrimidine

相似化合物

31462-54-1 4595-59-9 32779-37-6

上下游产品

5-Bromo-2-chloropyrimidine 2-hydroxypyrimidine hydr°Chloride 5-bromo-2-aminopyrimidine 2-pyrimidinone hydr°Chloride 5-bromo-2-(4-fluorophenyl)pyrimidine 2-(3',4'-Difluorophenyl)-5-bromopyrimidine 2-(2',3'-difluoro-4'-°Ctyloxyphenyl)-5-bromopyrimidine 5-bromo-2-(phenylethynyl)pyrimidine

2-羟基嘧啶盐酸盐置于溴,Sodium Hydroxide,N,N-二乙基苯胺,三氯氧磷,氢碘酸体系中,用 水,二氯甲烷 用作溶剂,化学反应 4.0H,反应生成5-溴-2-碘嘧啶
参考文献:高反应活性的吡啶和嘧啶二芳基胺抗氧化剂的制备
标题:高反应活性的吡啶和嘧啶二芳基胺抗氧化剂的制备
摘要:我们最近报告了对开发新型二芳基胺自由基捕获抗氧化剂(汉索恩(jj)等.J.上午 化学 Soc. 2012,134(8306-8309),其中我们证明了将环氮掺入二苯胺中可提供在h原子对过氧自由基的转移反应性与对单电子氧化的稳定性之间折衷的化合物.本文中,我们提供了与该报告相关的合成研究的详细信息,已对其进行了实质性扩展,以生成取代的杂环二芳基胺库,我们已使用该库进一步了解了这些化合物作为抗氧化剂的结构-反应性关系(请参阅随附的纸张,Doi:10.1021 / Jo301012X).简而言之,制备了二芳基胺 由2-氨基吡啶和2-氨基嘧啶组成的模块序列,其中中间体吡啶(mi)dyl溴化物的胺化以及然后pd催化的胺与前体溴化物的交叉偶联反应是生成二芳基胺的关键步骤.发现交叉偶联反应在pd(η3-1-Phc 3 ħ 4)(η 5-C 5 H ^ 5)作为前段催化剂,这给了比常规的pd源,钯更高的产量2(dba)3.
Doi:10.1021/jo301013C

专利信息

专利号:US-6121448-A
优先权日:1995-03-28
标题 :Pyrimidine compounds
发明人：LEWIS ROBERT ANDREWS; GOODBY JOHN WILLIAM; TOYNE KENNETH JOHNSON; HIRD MICHAEL
权利人:SECR DEFENCE BRIT
摘要:The synthesis of novel compound (I) is described: 5-bromo-2-iodopyrimidine may be used for the synthesis of a range of chemical compounds both known and novel. The synthesis of a number of novel liquid crystalline compounds is described.

专利号:US-11066395-B2
优先权日:2016-09-30
标题:Dimethylaminoethanol salt of a GLP-1 receptor modulator
发明人：VIDAL EPHRAIM; BAKALE ROGER; TURNBULL PHILIP; MOSER DAVID; ROBBINS ANDREW; GRANT CRAIG
权利人:RECEPTOS LLC
摘要:Crystalline 2-hydroxy-N,N-dimethylethanaminium 1-(2-(5-(tert-butyl)-thiophene-2-carboxamido)-3-(4-(5-(4′-ethyl-[1,1′-bi(cyclohexan)]-3-en-4-yl)pyrimidin-2-yl)phenyl)propanoyl)azetidine-3-carboxylate salt, and methods related to synthesis and therapeutic use of the same.

专利号:US-9839664-B2
优先权日:2014-07-25
标 题 :GLP-1 receptor modulators
发明人：BOEHM MARCUS F; MARTINBOROUGH ESTHER; MOORJANI MANISHA; TAMIYA JUNKO; HUANG LIMING; YEAGER ADAM R; BRAHMACHARY ENUGURTHI; FOWLER THOMAS; NOVAK ANDREW; MEGHANI PREMJI; KNAGGS MICHAEL
权利人:CELGENE INT II SÀRL
摘要:Compounds are provided that modulate the glucagon-like peptide 1 (GLP-1) receptor, as well as methods of their synthesis, and methods of their therapeutic and/or prophylactic use. Such compounds can act as modulators or potentiators of GLP-1 receptor on their own, or with incretin peptides such as GLP-1(7-36), GLP-1(9-36), and oxyntomodulin, or with peptide-based therapies, such as exenatide and liraglutide, and have the following general structure (where “ †represents either or both the R and S form of the compound): n nwhere A, B, C, R 1 , R 2 , R 3 , R 4 , R 5 , n, p and q are as defined herein.

专利号:US-9795613-B2
优先权日:2014-12-10
标题 :GLP-1 receptor modulators
发明人：BOEHM MARCUS F; MARTINBOROUGH ESTHER; MOORJANI MANISHA; TAMIYA JUNKO; HUANG LIMING; YEAGER ADAM R; BRAHMACHARY ENUGURTHI; FOWLER THOMAS; NOVAK ANDREW; MEGHANI PREMJI; KNAGGS MICHAEL; GLYNN DANIEL; MILLS MARK
权利人:CELGENE INT II SÀRL
摘要:Compounds are provided that modulate the glucagon-like peptide 1 (GLP-1) receptor, as well as methods of their synthesis, and methods of their therapeutic and/or prophylactic use. Such compounds can act as modulators or potentiators of GLP-1 receptor on their own, or with incretin peptides such as GLP-1(7-36) and GLP-1(9-36), or with peptide-based therapies, such as exenatide and liraglutide, and have the following general structure (where “ †represents either or both the R and S form of the compound): n nwhere A, B, C, Y 1 , Y 2 , Z, R 1 , R 2 , R 3 , R 4 , R 5 , W 1 , n, p and q are as defined herein.

专利号:US-11530205-B2
优先权日:2017-04-28
标题:GLP-1 receptor modulators
发明人：TAMIYA JUNKO; TURNBULL PHILIP; ENUGURTHI BRAHMACHARY; HUANG LIMING; YEAGER ADAM R; FOWLER THOMAS; IACOBINI GREG P; CRITTALL MATTHEW RICHARD
权利人:RECEPTOS LLC
摘要:Compounds are provided that modulate the glucagon-like peptide 1 (GLP-1) receptor, as well as products containing such compounds, and methods of their use and synthesis. Such compounds have the structure of Formula (I) below: (I) or pharmaceutically acceptable salts thereof, wherein A, J, W 1 , Y, Z, R 1 , R 2 , R 3 and R 4 are as defined herein.

专利号:US-9187522-B2
优先权日:2011-12-12
标题 :GLP-1 receptor modulators
发明人：BOEHM MARCUS F; MARTINBOROUGH ESTHER; MOORJANI MANISHA; TAMIYA JUNKO; HUANG LIMING; YEAGER ADAM R; BRAHMACHARY ENUGURTHI; FOWLER THOMAS; NOVAK ANDREW; MEGHANI PREMJI; KNAGGS MICHAEL
权利人:RECEPTOS INC
摘要:The invention relates to compounds that modulate the glucagon-like peptide 1 (GLP-1) receptor, methods of their synthesis, and methods of their therapeutic and/or prophylactic use. Such compounds are act as modulators or potentiators of GLP-1 receptor on their own, or with receptor ligands including GLP-1 peptides GLP-1(7-36) and GLP-1(9-36), or with peptide-based therapies, such as exenatide and liraglutide, and have the following general structure (where “ †represents either or both the R and S form of the compound): n nwhere A, B, C, Y 1 , Y 2 , Z, R 1 , R 2 , R 3 , R 4 , R 5 , W 1 , n, p and q are as defined herein.