专利号:US-9126995-B2 优先权日:2011-11-08 标题:Method for catalytic asymmetric synthesis of optically active isoxazoline compound and optically active isoxazoline compound 发明人:TOYAMA KEN-ICHI; MORIYAMA YUJI; MATOBA KAZUTAKA; YAOSAKA MANABU; IKEDA EITATSU 权利人:NISSAN CHEMICAL IND LTD 摘要:There is provided a method for catalytic asymmetric synthesis of optically active isoxazoline compound and an optically active isoxazoline compound. A method for catalytic asymmetric synthesis of optically active isoxazoline compound of a formula (6) including reacting an α,β-unsaturated carbonyl compound of a formula (1) and a hydroxylamine in a solvent in the presence of a base by adding a chiral phase transfer catalyst. An optically active isoxazoline compound of a formula (13) that can be synthesized by the method.
专利号:US-7767826-B2 优先权日:2007-10-05 标题 :Process for the synthesis of L-(+)-ergothioneine 发明人:TRAMPOTA MIROSLAV 权利人:PHARMATECH INTERNATIONAL INC 摘要:This invention relates to a novel process for the preparation of optically pure L-(+)-ergothioneine. The process for the chemical synthesis of L-ergothioneine comprises steps which consist of reacting L-histidine alkyl ester with an acid halide, chloroformate or pyrocarbonate in the presence of a base, hydrolysis of the alkyl-(S,Z)-2,4,5-triamidopent-4-enoate to obtain a (S)-alkyl 2,5-diamido-4-oxopentanoate, acid catalyzed hydrolysis of the (S)-alkyl 2,5-diamido-4-oxopentanoate followed by reaction with a metal thiocyanate to obtain the thiohistidine, protection of the sulfur of thiohistidine as the tert-butyl thioether, dialkylation of the primary amine to obtain a tertiary amine, quaternization of the tertiary amine, and removal of the protecting group to obtain the desired (S)-3-(2-mercapto-1H-imidazol-5-yl)-2-(trialkylammonio)propanoate (I). This process affords a better yield and is capable of practical application at large scale.
专利号:WO-2015155713-A1 优先权日:2014-04-09 标题 :Process for the regioselective synthesis of 1,3, 4 -substituted pyrazoles 发明人:MEAZZA GIOVANNI; MEREGHETTI PIERANGELO; SILLANI LAURA; FORGIA DANIELE; BELLANDI PAOLO 权利人:ISAGRO SPA 摘要:A process is described for the synthesis of pyrazoles having general formula (I) comprising the following steps: a) a mixture comprising an alkyl-hydrazine having formula (II) RNH-NH 2 and a compound having general formula (III) Rx 1 -X 1 -Rx-X 2 -Rx 2 , b) the mixture obtained in step a) is reacted with a compound having formula (IV), obtaining a 1,3,4-substituted pyrazole having general formula (I), according to the reaction scheme 1.
专利号:US-9512250-B2 优先权日:2012-02-23 标 题 :Manganese catalyzed photopolymerization of fluorinated monomers 发明人:ASANDEI ALEXANDRU D 权利人:UNIV CONNECTICUT 摘要:The disclosure discloses initiating systems for the radical polymerization of alkenes, and especially fluorine substituted alkenes. The polymerization is catalyzed by a metal carbonyl, preferably manganese carbonyl. The polymerization is initiated directly from alkyl halides at room temperature under visible white light. The polymers also allow the synthesis of block copolymers. The process comprises polymerizing at least one alkene monomer in the presence of a halide radical initiator, carbonyl catalyst and a solvent, under reaction conditions and for a time sufficient to polymerize the at least one alkene monomer to form a polymer. The present disclosure provides a method for living polymerization of alkene monomers which provides a high level of macromolecular control over the polymerization process and which leads to uniform and controllable polymeric products. This disclosure also provides a method for activating any halide (Cl, Br, I) chain ends of such polymers for the synthesis of block copolymerizations.
专利号:US-2014199585-A1 优先权日:2013-01-17 标 题 :Low Symmetry Molecules And Phosphonium Salts, Methods Of Making And Devices Formed There From 发明人:RUPERT BENJAMIN L; BEER LEANNE 权利人:ESIONIC ES INC 摘要:Synthesis of molecules and salts is disclosed having low average symmetry and their use in many applications, including but not limited to: as electrolytes in electronic devices such as memory devices including static, permanent and dynamic random access memory, as electrolytes in energy storage devices such as batteries, electrochemical double layer capacitors (EDLCs) or supercapacitors or ultracapacitors, electrolytic capacitors, as electrolytes in dye-sensitized solar cells (DSSCs), as electrolytes in fuel cells, as a heat transfer medium, high temperature reaction and/or extraction media, among other applications. In particular, synthesis methods and processes to form molecules and salts having low average symmetry using mixed Grignard reagents are disclosed.
专利号:US-8563789-B2 优先权日:2007-06-27 标题 :Process for the manufacture of hydrofluoroolefins 发明人:ELSHEIKH MAHER Y; BONNET PHILIPPE; CHEN BENJAMIN BIN 权利人:ELSHEIKH MAHER Y; BONNET PHILIPPE; CHEN BENJAMIN BIN; ARKEMA INC 摘要:In this invention we are disclosing a process for the synthesis of hydrocchlorofluoro olefins (HCFO) and/or hydrofluoroolefins (HFO). The process is based on the steps of fluorination of hydrochloropropenes or hydrochloropropanes to form hydrochlorofluoropropenes and/or hydrofluoropropenes, followed by gas phase, catalytic fluorination of the hydrochlorofluoropropenes to form hydrofluoropropenes.
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