N-(异丙氧羰基)-L-缬氨酸置于n,N-二甲基苄胺,Sodium Hydroxide体系中,用 甲苯 用作溶剂,化学反应 6.0H,反应生成苯噻菌胺 参考文献:Synthesis And In Vitro Evaluation Of New Derivatives Of 2-Substituted-6-Fluorobenzo[d]Thiazoles As Cholinesterase Inhibitors 标题:Synthesis And In Vitro Evaluation Of New Derivatives Of 2-Substituted-6-Fluorobenzo[d]Thiazoles As Cholinesterase Inhibitors 摘要:A Series Of Novel Cholinesterase Inhibitors Based On 2-Substituted 6-Fluorobenzo[d]Thiazole Were Synthesised And Characterised By Ir,H-1,C-13 And F-19 NMR Spectroscopy And Hrms. Purity Was Checked By Elemental Analyses. The Novel Carbamates Were Tested For Their Ability To Inhibit Acetylcholinesterase (Ache) And Butyrylcholinesterase (Bche). The Toxicity Of The Most Active Compounds Was Investigated Using A Standard In Vitro Test With Hepg2 Cells,And The Ratio Between Biological Activity And Toxicity Was Determined. In Addition,The Toxicity Of The Most Active Compounds Was Evaluated Against Mcf7 Cells Using The Xcelligence System. Structure-Activity Relationships Reflecting The Dependence Of Cholinesterase Inhibitors On The Lipophilicity Of The Compounds As Well As On The Taft Polar And Steric Substituent Constants Are Discussed. The Specific Orientation Of The Inhibitors In The Binding Site Of Acetylcholinesterase Was Determined Using Molecular Docking Of The Most Active Compound. (C) 2013 Elsevier Ltd. All Rights Reserved. Doi:10.1016/j.Bmc.2013.01.052
专利号:US-9968097-B2 优先权日:2012-05-30 标题:Composition comprising a biological control agent and a fungicide selected from inhibitors of the lipid membrane synthesis, the melanine biosynthesis, the nucleic acid synthesis or the signal transduction 发明人:WACHENDORFF-NEUMANN ULRIKE; ANDERSCH WOLFRAM; STENZEL KLAUS; SPRINGER BERND 权利人:BAYER CROPSCIENCE AG 摘要:The present invention relates to a composition comprising at least one biological control agent. Furthermore, the present invention relates to the use of this composition as well as a method for reducing overall damage of plants and plant parts.
专利号:US-2007232495-A1 优先权日:2006-03-24 标题:Compositions and methods to add value to plant products, increasing the commercial quality, resistance to external factors and polyphenol content thereof 发明人:NAPPA ALVARO O; LORENZINI FELIPE C; SANHUEZA ANDRES L 权利人:NAPPA ALVARO O; LORENZINI FELIPE C; SANHUEZA ANDRES L 摘要:The invention is related to compositions and methods that naturally protect plant tissues against ultraviolet radiation and temperature, thus giving protection against sunburn to plants, plant parts, fruits and/or flowers during their development. The invention is also related to compositions and methods to naturally improve the color of plants, plant parts, fruits and/or flowers by inducing the natural synthesis of flavonoids and anthocyanins present in plants. Likewise, the present invention is directed to improving the nutritional value of plants, plant parts, fruits and/or flowers by increasing the normal levels of polyphenolic compounds, especially flavonoids, present therein. Additionally, the present invention is related to compositions and methods that give more resistance to plants, plant parts, fruits and/or flowers against pathogens as bacteria and fungi. Finally, the present invention is related to plants, plant parts, fruits, flowers and/or propagating material treated with the compositions described in the present document.
专利号:US-9706777-B2 优先权日:2012-05-30 标题:Composition comprising a biological control agent and a fungicide selected from inhibitors of amino acid or protein biosynthesis, inhibitors of ATP production and inhibitors of the cell wall synthesis 发明人:WACHENDORFF-NEUMANN ULRIKE; ANDERSCH WOLFRAM; STENZEL KLAUS; SPRINGER BERND 权利人:BAYER CROPSCIENCE AG 摘要:The present invention relates to a composition comprising at least one biological control agent. Furthermore, the present invention relates to the use of this composition as well as a method for reducing overall damage of plants and plant parts.
专利号:TW-I491356-B 优先权日:2010-02-23 标题:Synthesis of 2-ethyl-3,7-dimethyl-6-(4-(trifluoromethoxy)phenoxy) quinolin-4-ylmethyl carbonate and a method for producing the same Crystallization of the pesticide composition
专利号:EP-3590340-B1 优先权日:2010-09-01 标 题:Intermediates for the synthesis of fungicidal pyrazoles
专利号:US-2015272130-A1 优先权日:2012-12-03 标 题:Composition comprising a biological control agent and a fungicide 发明人:WACHENDORFF-NEUMANN ULRIKE; DAHMEN PETER; SAWADA HARUKO 权利人:BAYER CROPSCIENCE AG 摘要:The present invention relates to a composition comprising at least one biological control agent selected from the group consisting of Paecilomyces lilacinus strain 251 (AGAL No. 89/030550) and Coniothyrium minitans CON/M/91-08 (DSM 9660) and/or a mutant of these strains having all the identifying characteristics of the respective strain, and/or at least one metabolite produced by the respective strain that exhibits activity against nematodes, insects and/or phytopathogens, and at least one fungicide (I) selected from the group consisting of compounds capable to introduce a host defence, inhibitors of the amino acid and/or protein biosynthesis, inhibitors of the ATP production, inhibitors of the cell wall synthesis, inhibitors of the lipid and membrane synthesis, inhibitors of the melanine biosynthesis, inhibitors of the nucleic acid synthesis, inhibitors of the signal transduction, compounds capable to act as an uncoupler, and other fungicides in a synergistically effective amount. Furthermore, the present invention relates to a kit of parts comprising said composition and the use of said composition.
1: European Food Safety Authority (EFSA); Alvarez F, Arena M, Auteri D, Borroto J, Brancato A, Carrasco Cabrera L, Castoldi AF, Chiusolo A, Colagiorgi A, Colas M, Crivellente F, De Lentdecker C, Egsmose M, Fait G, Ferilli F, Gouliarmou V, Greco L, Ippolito A, Istace F, Jarrah S, Kardassi D, Kienzler A, Leuschner R, Lava R, Linguadoca A, Lythgo C, Magrans O, Mangas I, Miron I, Molnar T, Padovani L, Parra Morte JM, Pedersen R, Reich H, Santos M, Sharp R, Szentes C, Terron A, Tiramani M, Vagenende B, Villamar-Bouza L. Peer review of the pesticide risk assessment of the active substance benthiavalicarb (variant assessed benthiavalicarb-isopropyl). EFSA J. 2021 Sep 27;19(9):e06833. doi: 10.2903/j.efsa.2021.6833. 2: Omelchuk S, Syrota A, Vavrinevych O, Blagaia A, Lisovska V, Reshavska O. Experimental study on the carcinogenic effects of pesticides with ascertained carcinogenic activity under the conditions of its simultaneous influence on the organism of laboratory animals. Wiad Lek. 2018;71(7):1274-1280. 15(1):e0227556. doi: 10.1371/journal.pone.0227556. 4: Cohen Y, Rubin AE, Galperin M. Effective control of two genotypes of Phytophthora infestans in the field by three oxathiapiprolin fungicidal mixtures. PLoS One. 2021 Oct 8;16(10):e0258280. doi: 10.1371/journal.pone.0258280.