CAS: 1343-88-0; Magnesium Silicate Adsorbent(Synthetic)

专利信息

专利号:US-12221452-B2
优先权日:2017-10-04
标题:Synthesis of cantharidin
发明人：DAVIDSON MATTHEW GENE; EKLOV BRIAN MATTHEW; WUTS PETER; LOERTSCHER BRAD MELVIN; SCHOW STEVEN R
权利人:VERRICA PHARMACEUTICALS INC
摘要:The invention provides synthetic methods for the preparation of cantharidin and analogs thereof. In one aspect, the invention provides an improved Diels-Alder cycloaddition to generate a key intermediate en route to cantharidin and analogs thereof. In certain embodiments, the new Diels-Alder reaction involves reacting Compound (2) in the presence of furan, and in the absence of acid or increased pressure, in an aprotic polar solvent with slight warming, to yield Compound (1) in favorable yield and exo-endo ratio. In another aspect, the invention also provides a new Diels-Alder reaction between compounds of Formula (III) and furan to yield compounds of Formula (IV), which can then be transformed into cantharidin or analogs thereof. In yet another aspect, the invention describes a new palladium-mediated carbonylation providing another key intermediate en route to cantharidin and analogs thereof. In addition to synthetic methods, present invention also provides compounds (i.e., intermediates) useful in the synthesis of cantharidin and analogs thereof. Compounds provided herein may have biological activity, and therefore may be used in the treatment of diseases or conditions (e.g., infectious diseases and skin conditions).

专利号:US-11292873-B2
优先权日:2013-11-05
标 题 :Etheramines prepared from a mixture of two or more multifunctional alcohol initiators, and their use as curatives or intermediates for polymer synthesis
发明人：ZHOU HUI; LEWIS DAVID C; KLEIN HOWARD P; RENKEN TERRY L; PATTERSON LEAH
权利人:HUNTSMAN PETROCHEMICAL LLC
摘要:Implementations described herein generally relate to etheramine mixtures formed from a mixture of two or more multifunctional alcohol initiators, processes for the etheramine mixtures production, and its use as a curing agent or as a raw material in the synthesis of polymers. In one implementation, the process comprises mixing a polyol initiator having a melting point greater than a processing temperature and a polyol initiator having a melting point less than the processing temperature to form a polyol initiator mixture having a melting point less than the processing temperature, charging the polyol initiator mixture to an alkoxylation reaction zone, contacting the polyol initiator mixture with an alkylene oxide in the alkoxylation reaction zone to provide a mixture of alkoxylated precursor polyols and charging the mixture of alkoxylated precursor polyols to a reductive amination zone and reductively aminating the mixture of alkoxylated precursor polyols to form the etheramine mixture.

专利号:US-12338129-B2
优先权日:2018-12-21
标题 :Synthesis of hectorite-type mineral
发明人：LU JIE; YIP BENJAMIN; GREENE MICHAEL
权利人:IMERYS USA INC
摘要:A method of making a synthetic hectorite-type mineral is described, along with its resulting physical and rheological properties. The synthetic hectorite-type mineral is a 2:1 phyllosilicate essentially free of aluminum, and having a trioctahedral structure with Mg2+ and Li+ occupying octahedral sites. As a hydrogel, the synthetic hectorite-type mineral has a swell index of greater than 55 mL, and a yield point of greater than 290 Pa. The method of making uses a MgO/MgCO3 buffer system, with heating for about 2 hours at temperatures of no higher than 300° C. and pressures of no higher than 600 psi.

专利号:US-9150590-B2
优先权日:2011-05-19
标 题 :Process for the synthesis of rifaximin and a new pseudo-crystalline form of rifaximin obtained thereby
发明人：MAZZOLA DISMA; MOIANA SILVIA; COPPI GERMANO
权利人:MAZZOLA DISMA; MOIANA SILVIA; COPPI GERMANO; FRIULCHEM SPA
摘要:Process for the preparation of rifaximin, pseudo-crystalline rifaximin and a new pseudo-crystalline form of rifaximin with fewer impurities obtained thereby.

专利号:US-4376721-A
优先权日:1981-07-22
标题:Methanol synthesis catalyst and method for its preparation
发明人：HUANG DINAH C
权利人:ELECTRIC POWER RES INST
摘要:A method is provided to promote, stabilize and strengthen metal catalysts used in the fluidized bed process for methanol synthesis which comprises the dipping of such catalysts into an alcoholic solution of metal alkoxide salt. The resulting improved catalyst is characterized by high density, low loss on attrition, and improved stability and catalytic activity.

专利号:US-12202937-B2
优先权日:2018-09-25
标 题:Cyclic amide initialized polyetheramine and uses thereof
发明人：ZHAO HAIBO
权利人:HUNTSMAN PETROCHEMICAL LLC
摘要:A polyetheramine produced from a cyclic amide initiator which is first alkoxylated and then reductively aminated to form the polyetheramine. The polyetheramine of the present disclosure may be used in a variety of applications, such as a raw material in the synthesis of a dispersant for use in an aqueous pigment dispersion or as a fuel additive in a hydrocarbon fuel composition.