Alkaline Earth Salt Of/the/ Methylsulfuric Acid置于alkali Nitrite体系中,化学反应生成亚硝酸异戊酯 参考文献:Neogi,Journal Of The Chemical Society,1914,Vol. 105,P. 2375 标题:Neogi,Journal Of The Chemical Society,1914,Vol. 105,P. 2375
专利号:US-10954178-B1 优先权日:2020-08-28 标题 :Synthesis of haloindenes 发明人:WNUK STANISLAW F; HOWLADER MD ABU HASAN 权利人:WNUK STANISLAW F; HOWLADER MD ABU HASAN; THE FLORIDA INTERNATIONAL UNIV BOARD OF TRUSTEES 摘要:The subject invention provides an expedited synthesis of 5, 6, and 7-iodoindenes from the corresponding aminoindan-1-ones in more than 70% yield, employing readily available precursors and reagents. A three-step sequence involves diazotization-iodination of aminoindan-1-one followed by reduction and dehydration. The method has a general character and can be extended for the preparation of various 4-, 5-, 6- or 7-haloindenes using different halogen sources for diazotization-halogenation reaction.
专利号:US-11040938-B2 优先权日:2016-07-27 标 题 :Continuous flow process for the synthesis of phenylhydrazine salts and substituted phenylhydrazine salts 发明人:MA BING; PAN SHUAI 权利人:SHANGHAI HYBRID—CHEM TECH; SHANGHAI HYBRID CHEM TECH 摘要:The present invention provided a continuous flow process for the synthesis of phenylhydrazine salts and substituted phenylhydrazine salts. Diazotization, reduction, acidic hydrolysis and salifying with acids are innovatively integrated together. Using acidic liquids of aniline or substituted aniline, diazotization reagents, reductants and acids as raw materials, phenylhydrazine derivative salts is obtained through the synthesis process, which is a three-step continuous tandem reaction including diazotization, reduction, acidic hydrolysis and salifying. The described synthesis process is a kind of integrated solutions, which is carried out in an integrated reactor. The feed inlets of the integrated reactor are continuously filled with raw materials. In the integrated reactor, diazotization, reduction, acidic hydrolysis and salifying are carried out continuously and orderly, and phenylhydrazine salts or substituted phenylhydrazine salts is obtained in the outlet of the integrated reactor without interruption. The total reaction time is no more than 20 min.
专利号:US-7332634-B2 优先权日:2002-07-23 标题:Method for the continuous purification by distillation of 1,2-propylene glycol that accumulates during the synthesis of propylene oxide without coupling products 发明人:BASSLER PETER; GOEBBEL HANS-GEORG; TELES JOAQUIM HENRIQUE; RUDOLF PETER 权利人:BASF AG 摘要:The invention relates to a continuously operated process for the purification by distillation of the 1,2-propylene glycol formed as by-product in the synthesis of propylene oxide, wherein the mixture formed in the synthesis which contains the 1,2-propylene glycol is separated in a dividing wall column into low-, intermediate- and high-boiling fractions and the 1,2-propylene glycol is taken off as intermediate boiler at the side offtake of the column.
专利号:US-11639349-B2 优先权日:2020-05-28 标题:Stereoselective synthesis of intermediate for preparation of heterocyclic compound 发明人:CHEN WEN-CHANG; HSU HAN-PEI; CHOU SHAN-YEN; CHUANG SHIH-CHIEH; YEN CHI-FENG 权利人:TAI GEN BIOTECHNOLOGY CO LTD; TAIGEN BIOPHARMACEUTICALS CO BEIJING LTD; TAIGEN BIOTECHNOLOGY CO LTD 摘要:Provided is a stereoselective synthesis of an intermediate for the preparation of the heterocyclic derivative as a Cap-dependent endonuclease inhibitor. The synthesis process has the advantages of simple operation, higher yield and relatively controllable steroselectivity, such that it is suitable for large-scale production.
专利号:WO-0100609-A1 优先权日:1999-06-29 标题:Method for synthesis of n-homocysteine thiolactonyl retinamide 发明人:KAZIMIR MICHAEL; WILSON RAY E II 权利人:UNIV BAYLOR; KAZIMIR MICHAEL; WILSON RAY E II 摘要:The present invention describes methods of synthesis for N-homocysteine thiolactonyl retinamide (thioretinamide), a compound that has anticancer and antiatherogenic properties. The present invention further describes methods for the synthesis of N-homocysteine thiolactonyl retinamido cobalamin (thioretinaco), a compound that has potential anticancer, antineoplastic, antiviral, and antiatherogenic properties.
专利号:US-9469614-B2 优先权日:2011-10-27 标 题:Synthesis of triazolopyrimidine compounds 发明人:ZUPANCIC BORUT; MARAS NENAD; STERK DAMJAN 权利人:LEK PHARMACEUTICALS 摘要:The present invention relates to the field of organic synthesis and describes the synthesis of specific triazolopyrimidine compounds and intermediates thereof as well as related derivatives.
1: Moriwaki R. [Amyl nitrite, sodium nitrite, sodium thiosulfate]. Chudoku Kenkyu. 2015 Dec;28(4):383-7. Review. Japanese. doi: 10.1002/bio.2466. Epub 2013 Jan 9. doi: 10.1002/ajh.24229. doi: 10.3109/15563650.2010.505573. Review. doi: 10.1021/tx400103k. Epub 2013 Apr 19. 6: Mullens AB, Young RM, Dunne MP, Norton G. The Amyl Nitrite Expectancy Questionnaire for Men who have Sex with Men (AEQ-MSM): a measure of substance-related beliefs. Subst Use Misuse. 2011;46(13):1642-50. doi: 10.3109/10826084.2011.599096. Epub 2011 Jul 27. doi: 10.1016/j.medmal.2012.07.008. Epub 2012 Nov 12. French. 10: Chrysant SG, Dunn FG, De Carvalho JG, Adamopoulos PN, Frolich ED. Action of Nitroglycerin and amyl nitrite in labile and essential hypertension: hemodynamic differences. Arch Intern Med. 1977 Dec;137(12):1702-5. doi: 10.1021/jp209727g. Epub 2012 Jan 9. doi: 10.1093/qjmed/hcq162. Epub 2010 Sep 15. doi: 10.1017/cjn.2014.42. Epub 2014 Nov 10. doi: 10.1016/j.amjcard.2017.08.047. Epub 2017 Sep 19.
合成参考文献
参考文献:10.1080/10550880903014726 摘要:Hatfield LA, Horvath KJ, Jacoby SM, Simon Rosser BR. Comparison of Substance Use and Risky Sexual Behavior Among a Diverse Sample of Urban, HIV-Positive Men Who Have Sex with Men. Journal of Addictive Diseases. 2009 Jul 06;28(3):208–18. doi: 10.1080/10550880903014726.