CAS: 1092578-45-4; N-((3R,4S)-1-Benzyl-4-Methylpiperidin-3-yl)-N-Methyl-7H-Pyrrolo[2,3-D]Pyrimidin-4-Amine
该化合物是一种化学化合物,其结构复杂,包括一个管状环和一个环状硅酰胺.该化合物具有一个手性中心的特点,有助于其立体化学,特别是3R,4S的配置.苯基集团的存在增强了其亲性,有可能影响其生物活动和药用植物学.N-甲基替代表明氮原子有一个附属于甲基组,可影响该化合物与生物目标的相互作用.该物质可能具有与药用化学有关的特性,特别是在药物开发方面,因为它可能与生物系统中的各种受体或酶发生相互作用.其具体应用和功效将取决于进一步的研究,包括体外和活性评估.正如在药物发现中的许多化合物一样,了解其溶解性,稳定性和治疗性用途是其治疗性用途的关键.
- 英文名称N-((3R,4S)-1-Benzyl-4-Methylpiperidin-3-yl)-N-Methyl-7H-Pyrrolo[2,3-D]Pyrimidin-4-Amine
- 中文名称托法替尼-IMZ10
- IUPAC名称N-((3R,4S)-1-benzyl-4-methylpiperidin-3-yl)-N-methyl-7H-pyrrolo[2,3-d]pyrimidin-4-amine
- 其它别名N-((3R,4S)-1-Benzyl-4-Methylpiperidin-3-yl)-N-Methyl-7H-Pyrrolo[2,3-D]Pyrimidin-4-Amine; Tofatinib Impurity 22; N-((3R,4S)-1-Benzyl-4-Methylpiperidin-3-yl)-N-Methyl-7H-Pyrrolo[2,3-D]Pyrimidin-4-Amine (Tofacitinib Impurity）; 7H-Pyrrolo[2,3-D]Pyrimidin-4-Amine, N-Methyl-N-[(3R,4S)-4-Methyl-1-(Phenylmethyl)-3-Piperidinyl]-
- CAS编号1092578-45-4
- 分子式:C20H25N5分子量:335.45
- 产品CID: 128682
- 产品分类有机原料 → 有机杂环化合物 → 哌啶类
MSDS等安全信息
上下游产品
N-((3R,4S)-1-benzyl-4-methylpiperidin-3-yl)-N-methyl-7-tosyl-7H-pyrrolo[2,3-d]pyrimidin-4-amine合成工艺路线路线简述
📜N-((3R,4S)-1-Benzyl-4-Methylpiperidin-3-yl)-N-Methyl-7-Tosyl-7H-Pyrrolo[2,3-D]Pyrimidin-4-Amine置于水,Sodium Hydroxide体系中,化学反应 6.0H,反应生成托法替尼-Imz10
参考文献:Examining The Chirality,Conformation And Selective Kinase Inhibition Of 3-((3R,4R)-4-Methyl-3-(Methyl(7H-Pyrrolo[2,3-D]Pyrimidin-4-yl)Amino)Piperidin-1-yl)-3-Oxopropanenitrile (Cp-690,550)
标题:Examining The Chirality,Conformation And Selective Kinase Inhibition Of 3-((3R,4R)-4-Methyl-3-(Methyl(7H-Pyrrolo[2,3-D]Pyrimidin-4-yl)Amino)Piperidin-1-yl)-3-Oxopropanenitrile (Cp-690,550)
摘要:Here,We Examine The Significance That Stereochemistry Plays Within The Clinically Relevant Janus Kinase 3 (Jak3) Inhibitor 1 (Cp-690,550). A Synthesis Of All Four Enantiopure Stereoisomers Of The Drug Was Carried Out And An Examination Of Each Compound Revealed That Only The Enantiopure 3R,4R Isomer Was Capable Of Blocking Stat5 Phosphorylation (Jak3 Dependent). Each Compound Was Profiled Across A Panel Of Over 350 Kinases,Which Revealed A High Level Of Selectivity For The Jak Family Kinases For These Related Compounds. Each Stereoisomer Retained A Degree Of Binding To Jak3 And Jak2 And The 3R,4S And 3S,4R Stereoisomers Were Further Revealed To Have Binding Affinity For Selected Members Of The Ste7 And Ste20 Subfamily Of Kinases. Finally,An Appraisal Of The Minimum Energy Conformation Of Each Stereoisomer And Molecular Docking At Jak3 Was Performed In An Effort To Better Understand Each Compounds Selectivity And Potency Profiles.
Doi:10.1021/jm801142B
参考文献:Examining The Chirality,Conformation And Selective Kinase Inhibition Of 3-((3R,4R)-4-Methyl-3-(Methyl(7H-Pyrrolo[2,3-D]Pyrimidin-4-yl)Amino)Piperidin-1-yl)-3-Oxopropanenitrile (Cp-690,550)
标题:Examining The Chirality,Conformation And Selective Kinase Inhibition Of 3-((3R,4R)-4-Methyl-3-(Methyl(7H-Pyrrolo[2,3-D]Pyrimidin-4-yl)Amino)Piperidin-1-yl)-3-Oxopropanenitrile (Cp-690,550)
摘要:Here,We Examine The Significance That Stereochemistry Plays Within The Clinically Relevant Janus Kinase 3 (Jak3) Inhibitor 1 (Cp-690,550). A Synthesis Of All Four Enantiopure Stereoisomers Of The Drug Was Carried Out And An Examination Of Each Compound Revealed That Only The Enantiopure 3R,4R Isomer Was Capable Of Blocking Stat5 Phosphorylation (Jak3 Dependent). Each Compound Was Profiled Across A Panel Of Over 350 Kinases,Which Revealed A High Level Of Selectivity For The Jak Family Kinases For These Related Compounds. Each Stereoisomer Retained A Degree Of Binding To Jak3 And Jak2 And The 3R,4S And 3S,4R Stereoisomers Were Further Revealed To Have Binding Affinity For Selected Members Of The Ste7 And Ste20 Subfamily Of Kinases. Finally,An Appraisal Of The Minimum Energy Conformation Of Each Stereoisomer And Molecular Docking At Jak3 Was Performed In An Effort To Better Understand Each Compounds Selectivity And Potency Profiles.
Doi:10.1021/jm801142B
供应商参考报价(招募中)
品牌试剂参考报价(招募中)
📌 第三方产品分析报告
合成参考文献
合成方法参考DOI号:10.1021/jm801142b
📝 需求与反馈
尽可能描述清楚需求与问题信息
