CAS: 109-00-2; Pyridin-3-Ol

上下游产品

CAS号6602-28-4 3-羟基吡啶-N-氧化物 | CAS号626-55-1 3-溴吡啶 | CAS号626-60-8 3-氯吡啶 | CAS号1692-25-7 吡啶-3-硼酸 | CAS号17747-43-2 3-乙酰氧基吡啶 | CAS号7295-76-3 3-甲氧基吡啶 | CAS号1120-90-7 3-碘吡啶 | CAS号849774-31-8 3-[(triisopropy... | CAS号1063697-17-5 2-(三氟甲基)吡啶-3-醇 | CAS号106851-76-7 3-(2,2-dimethox... | CAS号104642-51-5 1-(2,4-dinitrop... | CAS号55717-46-9 3-氨基-3-吡啶醇 | CAS号372-47-4 3-氟吡啶 | CAS号3554-74-3 3-羟基-N-甲基哌啶 | CAS号5519-50-6 1-甲基-3-哌啶酮 | CAS号141032-72-6 吡唑并[1,5-a]吡啶-4-醇 | CAS号14187-25-8 3-羟基-2,6-双(羟甲基)... | CAS号147699-68-1 4,5-Bis(3-pyrid...

吡啶置于硫酸,Mercury(II) Sulfate体系中,化学反应 10.0H,以62%的收率获得3-羟基吡啶
参考文献:一种(S)-1-叔丁氧羰基-3-羟基哌啶的制备方法
标题:一种(S)-1-叔丁氧羰基-3-羟基哌啶的制备方法
摘要:本发明公开了一种(S)‑1‑叔丁氧羰基‑3‑羟基哌啶的制备方法,涉及生物制药技术领域,包括如下步骤,步骤一,制备3‑羟基吡啶(2)作为原料;步骤二,通过3‑羟基吡啶(2)制备消旋3‑羟基哌啶(3);步骤三,消旋3‑羟基哌啶(3)经d‑酒石酸制得衍生物(2S,3S)‑n‑(4‑氯苯基)‑2,3‑二羟基丁酰胺酸(4);步骤四,将d‑酒石酸制得衍生物(2S,3S)‑n‑(4‑氯苯基)‑2,3‑二羟基丁酰胺酸(4)拆分得(S)‑羟基哌啶盐(5);步骤五,将混合物进行萃取,浓缩,结晶,制得(S)‑1‑叔丁氧羰基‑3‑羟基哌啶盐(5),本发明制备工艺减少了合成步骤,同时提高收率,可利用回收手性拆分剂,适合工业化生产.

专利信息

专利号:US-2024287520-A1
优先权日:2021-06-30
标题:Method for synthesis of linkage modified oligomeric compounds
发明人：RODRIGUEZ ANDREW A
权利人:IONIS PHARMACEUTICALS INC
摘要:The present disclosure provides methods of synthesizing modified oligonucletodies and oligomeric compounds (including oligomeric compounds that are antisense agents or portions thereof) comprising a modified oligonucleotide having at least one modified internucleoside linking group. In certain embodiments, the present disclosure provides stabilized formulations of certain sulfonyl azides for use in the synthesis of olignonucleotides comprising one or more sulfonyl phosphoramidate linkages. Some embodiments provide stabilized compositions of high energy reagents that may be used in the synthesis of modified oligonucleotides, allowing for safe process scale preparation thereof.

专利号:US-2004242897-A1
优先权日:2002-07-31
标题 :Universal support media for synthesis of oligomeric compounds
发明人：GUZAEV ANDREI P; MANOHARAN MUTHIAH
摘要:Compounds for the synthesis of oligomeric compounds, particularly oligonucleotides and oligonucleotide mimetics, are provided. In addition, methods for functionalizing a support medium with a first monomeric subunit and methods for the synthesis of oligomeric compounds utilizing the novel compounds bound to support media are provided.

专利号:US-2024092821-A1
优先权日:2020-03-31
标题:Synthesis of oligonucleotides and related compounds
发明人：ZHONG MINGHONG; JIN YI; GALA DINESH; PRHAVC MARIJA
权利人:JANSSEN BIOPHARMA INC
摘要:Methods of synthesizing oligonucleotides via new intermediates on a cleavable support having an azidomethyl moiety are disclosed. The method comprises multiple reaction cycles, each of which comprises sequential coupling a nucleoside or oligonucleotide subunit on a cleavable support having an azidomethyl moiety and a nucleoside phosphoramidite or an oligonucleotide phosphoramidite, capping, oxidation/thiolation and deblocking; followed by orthogonal cleavage of the azidomethyl support while keeping all other protecting groups intact. The method can be used in combination with a support moiety for either solid phase or liquid phase oligo synthesis. The soluble support facilitates homogeneous reactions and efficient separations by simple precipitation. The methods also provide novel intermediates useful in the synthesis of oligonucleotide conjugates.

专利号:US-7825244-B2
优先权日:2005-06-10
标题:Intermediates useful in the synthesis of alkylquinoline and alkylquinazoline kinase modulators, and related methods of synthesis
发明人：BAINDUR NAND; GAUL MICHAEL DAVID; KREUTTER KEVIN DOUGLAS; XU GUOZHANG
权利人:JANSSEN PHARMACEUTICA NV
摘要:The invention is directed to alkylquinoline and alkylquinazoline compounds of Formula C: n nwherein R 1 , R 2 , R 99 , and X are as defined herein, the use of such compounds in the synthesis of protein tyrosine kinase inhibitors, particularly inhibitors of FLT3 and/or c-kit and/or TrkB.

专利号:US-9688644-B2
优先权日:2009-04-30
标 题 :Synthesis of Tetracyclines and intermediates thereto
发明人：MYERS ANDREW G; KUMMER DAVID A; LI DERUN; HECKER EVAN; DION AMELIE; WRIGHT PETER M
权利人:HARVARD COLLEGE
摘要:The tetracycline class of antibiotics has played a major role in the treatment of infectious diseases for the past 50 years. However, the increased use of the tetracyclines in human and veterinary medicine has led to resistance among many organisms previously susceptible to tetracycline antibiotics. The recent development of a modular synthesis of tetracycline analogs through a chiral enone intermediate has allowed for the efficient synthesis of novel tetracycline analogs never prepared before. The present invention provides more efficient routes for preparing the enone intermediate and allows for substituents at positions 4a, 5, 5a, and 12a of the tetracycline ring system.

专利号:US-5723619-A
优先权日:1997-01-13
标 题 :Method for the synthesis of deoxypyridinoline
发明人：HATCH ROBERT P
权利人:BAYER AG
摘要:Disclosed is a method for the chemical synthesis of deoxypyridinoline (DPD). The synthesis involves the preparation of a protected 3-hydroxypyridinium starting with a Nα-protected lysine and a 5,6-epoxy-2-N-protected-O-protected-(2S)-2-aminohexanoate with subsequent deprotection to provide the desired DPD.