CAS: 883-92-1; 6-Chloro-2-Oxo-2H-Chromene-3-Carboxylic Acid

该化合物是属于铬类的化学化合物,它是双环化合物,含有苯环,并引信成一个保温环.该物质的特征是,六点存在氯替代物,三点存在一个碳酸化合物组,这助长了其酸性.在二点,该化合物展示了一种卡托组,它在有机合成中的再活动性和潜在应用中起着重要作用.该化合物一般在室温上是固态的,由于存在碳酸功能组,极溶剂中具有中等溶性.该化合物在各个领域都具有兴趣,包括医药化学和材料科学,因为它的潜在生物活动和在合成更复杂的分子中的效用.应当参考安全数据,以便处理和储存任何化学物质.

结构式图片

物理性质

MSDS等安全信息

上下游产品

CAS号70384-80-4 Ethyl 5-chloro-... | CAS号2033-24-1 丙二酸环(亚)异丙酯 | CAS号635-93-8 5-氯水杨醛 | CAS号105-53-3 丙二酸二乙酯 | CAS号141-82-2 丙二酸 | CAS号28447-81-6 6-氯-3-氰基香豆素 | CAS号742503-72-6 6-chloro-N-hydr... | CAS号87974-49-0 4-chloro-6-[(hy... | CAS号7035-09-8 5-氯-2-甲氧基苯甲醛

合成工艺路线路线简述

  • 2033-24-1 + 635-93-8 = 883-92-1
    反应条件:1.1 Solvents: Water; 55 Min,Rt
    标题:Aqueous Extract Of Acacia Concinna Pods: An Efficient Surfactant Type Catalyst For Synthesis Of 3-Carboxycoumarins And Cinnamic Acids Via Knoevenagel Condensation
    作者:Chavan,Hemant V.; Et Al
    参考文献:Acs Sustainable Chemistry & Engineering 日期:2013 卷标:1(8) 页码:929-936]

    70384-80-4 = 883-92-1
    反应条件:1.1 Reagents: Sodium Hydroxide Solvents: Ethanol,Water; 2 H,Reflux; Cooled1.2 Reagents: Hydrochloric Acid Solvents: Water; Rt
    标题:Synthesis,Characterization And Antimicrobial Activity Of A Series Of Substituted Coumarin-3-Carboxylato Silver(I) Complexes
    作者:Creaven,Bernadette S.; Et Al
    参考文献:Inorganica Chimica Acta 日期:2006 卷标:359(12) 页码:3976-3984]

    70384-80-4 = 883-92-1
    反应条件:1.1 Reagents: Sodium Hydroxide Solvents: Water1.2 Reagents: Hydrochloric Acid Solvents: Water
    标题:Synthesis Of Coumarin-3-O-Acylisoureas By Dicyclohexylcarbodiimide
    作者:Bonsignore,Leonardo; Et Al
    参考文献:Journal Of Heterocyclic Chemistry 日期:1995 卷标:32(2) 页码:573-7]

    28447-81-6 = 883-92-1
    反应条件:1.1 Reagents: Sodium Bicarbonate Solvents: Water; 2 H,Ph 8.3,90 °C; Ph 8.3,90 °C -> Rt1.2 Reagents: Hydrochloric Acid Solvents: Water; Ph 2,Rt
    标题:One-Pot Synthesis Of 3-Carboxycoumarins Via Consecutive Knoevenagel And Pinner Reactions In Water
    作者:Fringuelli,Francesco; Et Al
    参考文献:Synthesis 日期:2003 卷标:(15) 页码:2331-2334]

    105-53-3 + 635-93-8 = 883-92-1
    反应条件:1.1 Catalysts: Piperidine Solvents: Ethanol; 14 - 18 H,Reflux2.1 Reagents: Sodium Hydroxide Solvents: Water; 20 Min,Reflux; Cooled2.2 Reagents: Hydrochloric Acid Solvents: Water
    标题:Design,Synthesis And Biological Evaluation Of Coumarin-Based N-Hydroxycinnamamide Derivatives As Novel Histone Deacetylase Inhibitors With Anticancer Activities
    作者:Ding,Jiaoli; Et Al
    参考文献:Bioorganic Chemistry 日期:2020 卷标:101]

    2416400-44-5 = 883-92-1
    反应条件:1.1 2 H,Reflux
    标题:Novel Coumarin-Thiazolyl Ester Derivatives As Potential Dna Gyrase Inhibitors: Design,Synthesis,And Antibacterial Activity
    作者:Liu,Hao; Et Al
    参考文献:Bioorganic Chemistry 日期:2020 卷标:100]

    635-93-8 = 883-92-1 [标题:Reaction Conditions
    标题:Dearomatizative And Decarboxylative Reaction Cascade In The Aminocatalytic Synthesis Of 3,4-Dihydrocoumarins
    作者:Bojanowski,Jan; Et Al
    参考文献:Asian Journal Of Organic Chemistry 日期:2019 卷标:8(6) 页码:844-848]

    635-93-8 = 883-92-1
    反应条件:1.1 Reagents: Sodium Acetate,Hydroxyamine Hydrochloride Solvents: Acetonitrile,Water2.1 -3.1 Reagents: Sodium Hydroxide Solvents: Water
    标题:Inhibition Of Monoamine Oxidases By Coumarin-3-Acyl Derivatives: Biological Activity And Computational Study
    作者:Chimenti,Franco; Et Al
    参考文献:Bioorganic & Medicinal Chemistry Letters 日期:2004 卷标:14(14) 页码:3697-3703]

    = 883-92-1
    反应条件:1.1 Reagents: Sodium Hydroxide Catalysts: Tributylamine Solvents: Ethanol,Water; 60 °C; 40 Min,60 °C; Cooled1.2 Reagents: Hydrochloric Acid Solvents: Water; Ph 22.1 Catalysts: Acetic Acid,Piperidine Solvents: Ethanol; 6 H,Reflux2.2 Reagents: Sodium Hydroxide Solvents: Water; 0.5 H,Reflux2.3 Reagents: Hydrochloric Acid Solvents: Water; Ph 2,0 °C
    标题:Design And Synthesis Of Novel Vitamin D-Coumarin Hybrids Using Microwave Irradiation
    作者:Zhang,Hengrui; Et Al
    参考文献:Journal Of Chemical Research 日期:2017 卷标:41(12) 页码:684-687]

    2033-24-1 + 635-93-8 = 883-92-1
    反应条件:1.1 Catalysts: Sodium Azide Solvents: Water; 20 H,24 - 26 °C1.2 Reagents: Hydrogen Ion Solvents: Water; Acidified,Cooled
    标题:Room Temperature One-Pot Green Synthesis Of Coumarin-3-Carboxylic Acids In Water: A Practical Method For The Large-Scale Synthesis
    作者:Brahmachari,Goutam
    参考文献:Acs Sustainable Chemistry & Engineering 日期:2015 卷标:3(9) 页码:2350-2358]

    2033-24-1 + 635-93-8 = 883-92-1
    反应条件:1.1 Catalysts: β-Cyclodextrin Solvents: Water; 20 Min,70 °C
    标题:Synthesis Of Xanthene And Coumarin Derivatives In Water By Using β-Cyclodextrin
    作者:Kamat,Siddharth R.; Et Al
    参考文献:Research On Chemical Intermediates 日期:2021 卷标:47(3) 页码:911-924]

    70384-80-4 = 883-92-1
    反应条件:1.1 Reagents: Sodium Hydroxide,Hydrochloric Acid Solvents: Water
    标题:Biological Evaluation Of Coumarin Derivatives As Mushroom Tyrosinase Inhibitors
    作者:Liu,Jinbing; Et Al
    参考文献:Food Chemistry 日期:2012 卷标:135(4) 页码:2872-2878]

    2033-24-1 + 18362-30-6 = 883-92-1
    反应条件:1.1 Catalysts: Ammonium Acetate Solvents: Water; 2 - 3 H,Rt1.2 Reagents: Hydrochloric Acid Solvents: Water; Ph 4 - 5
    标题:Discovery Of 2H-Chromen-2-One Derivatives As G Protein-Coupled Receptor-35 Agonists
    作者:Wei,Lai; Et Al
    参考文献:Journal Of Medicinal Chemistry 日期:2017 卷标:60(1) 页码:362-372]

    2033-24-1 + 1570-64-5 = 883-92-1
    反应条件:1.1 Reagents: Tert-Butyl Hydroperoxide; 2.5 H,80 °C
    标题:A Practical Synthesis Of 3-Functionalized Coumarins From O-Cresols And Active Methylene Compounds Under Metal And Catalyst-Free Conditions Using Tert-Butyl Hydrogen Peroxide
    作者:Chauhan,Swati; Et Al
    参考文献:Chemistryselect 日期:2020 卷标:5(29) 页码:9030-9033]

    2033-24-1 = 883-92-1
    反应条件:1.1 Solvents: Ethanol; 10 Min,Reflux
    标题:Synthesis Of 5-Arylidene-2,2-Dimethyl-1,3-Dioxane-4,6-Diones And Coumarin-3-Carboxylic Acids Via Reaction Of Nitrones And Meldrum'S Acid
    作者:Kumar,Dhruva; Et Al
    参考文献:Indian Journal Of Chemistry 日期:2013 卷标:(8) 页码:1157-1160]

    105-53-3 + 635-93-8 = 883-92-1
    反应条件:1.1 Catalysts: Acetic Acid,Piperidine Solvents: Ethanol; 6 H,Reflux1.2 Reagents: Sodium Hydroxide Solvents: Water; 0.5 H,Reflux1.3 Reagents: Hydrochloric Acid Solvents: Water; Ph 2,0 °C
    标题:Design And Synthesis Of Novel Vitamin D-Coumarin Hybrids Using Microwave Irradiation
    作者:Zhang,Hengrui; Et Al
    参考文献:Journal Of Chemical Research 日期:2017 卷标:41(12) 页码:684-687]

    105-53-3 + 635-93-8 = 883-92-1
    反应条件:1.1 Catalysts: Piperidine Solvents: Ethanol; Overnight,Reflux2.1 Reagents: Sodium Hydroxide Solvents: Ethanol,Water; 1 H,Reflux2.2 Reagents: Hydrochloric Acid Solvents: Water
    标题:A Ru(Ii)-Catalyzed C-H Activation And Annulation Cascade For The Construction Of Highly Coumarin-Fused Benzo[a]Quinolizin-4-Ones And Pyridin-2-Ones
    作者:Wang,Jing; Et Al
    参考文献:Organic Chemistry Frontiers 日期:2023 卷标:10(11) 页码:2680-2687]

    635-93-8 = 883-92-1 [标题:Reaction Conditions
    标题:Decarboxylative,Trienamine Mediated Cycloaddition For The Synthesis Of 3,4-Dihydrocoumarin Derivatives
    作者:Albrecht,Anna; Et Al
    参考文献:Organic & Biomolecular Chemistry 日期:2019 卷标:17(17) 页码:4238-4242]

    742503-72-6 = 883-92-1
    反应条件:1.1 Reagents: Sodium Hydroxide Solvents: Water
    标题:Inhibition Of Monoamine Oxidases By Coumarin-3-Acyl Derivatives: Biological Activity And Computational Study
    作者:Chimenti,Franco; Et Al
    参考文献:Bioorganic & Medicinal Chemistry Letters 日期:2004 卷标:14(14) 页码:3697-3703]

    105-53-3 + 18362-30-6 = 883-92-1
    反应条件:1.1 Catalysts: Piperidine Solvents: Ethanol; Rt2.1 Reagents: Sodium Hydroxide,Hydrochloric Acid Solvents: Water
    标题:Biological Evaluation Of Coumarin Derivatives As Mushroom Tyrosinase Inhibitors
    作者:Liu,Jinbing; Et Al
    参考文献:Food Chemistry 日期:2012 卷标:135(4) 页码:2872-2878]

    321-14-2 + 105-53-3 = 883-92-1
    反应条件:1.1 Reagents: Piperidine Solvents: Ethanol,Acetic Acid; 12 H,80 °C2.1 Reagents: Sodium Hydroxide Solvents: Ethanol; Reflux
    标题:Evaluation Of Novel N'-(3-Hydroxybenzoyl)-2-Oxo-2H-Chromene-3-Carbohydrazide Derivatives As Potential Hiv-1 Integrase Inhibitors
    作者:Jesumoroti,Omobolanle J.; Et Al
    参考文献:Medchemcomm 日期:2019 卷标:10(1) 页码:80-88]

    635-93-8 = 883-92-1
    反应条件:1.1 Reagents: Sodium Hydroxide Solvents: Water; 4 H,Ph 12.4,Rt1.2 Reagents: Hydrochloric Acid Solvents: Water; 2 H,90 °C2.1 Reagents: Sodium Bicarbonate Solvents: Water; 2 H,Ph 8.3,90 °C; Ph 8.3,90 °C -> Rt2.2 Reagents: Hydrochloric Acid Solvents: Water; Ph 2,Rt
    标题:One-Pot Synthesis Of 3-Carboxycoumarins Via Consecutive Knoevenagel And Pinner Reactions In Water
    作者:Fringuelli,Francesco; Et Al
    参考文献:Synthesis 日期:2003 卷标:(15) 页码:2331-2334
📜6-Chloro-2-Imino-2H-Chromene-3-Carbonitrile置于盐酸,碳酸氢钠体系中,化学反应 4.0H,反应生成 6-氯-2-氧代-2H-苯并吡喃-3-羧酸
参考文献:One-Pot Synthesis Of 3-Carboxycoumarins Via Consecutive Knoevenagel And Pinner Reactions In Water
标题:One-Pot Synthesis Of 3-Carboxycoumarins Via Consecutive Knoevenagel And Pinner Reactions In Water
摘要:通过一步法,将适当取代的水杨醛与丙二腈在水中反应,成功制备了氯代,羟基,甲氧基和叔丁基取代的3-羧基香豆素.总体产率较高,且该方法无需使用有机溶剂.
DOI:10.1055/s-2003-41061

海关参考信息

专利信息


专利号:WO-2023141114-A2
优先权日:2022-01-18
标 题:Synthesis of boron-containing amidoxime reagents and their application to synthesize functionalized oxadiazole and quinazolinone derivatives

专利号:CN-111455005-B
优先权日:2020-02-29
标题 :A Method for Online Enzymatic Synthesis of Coumarin-3-Carboxylic Acid-6'-O-D-Sucrose Ester Derivatives Based on Flow Chemistry

专利号:CN-111455005-A
优先权日:2020-02-29
标 题:A method for online enzymatic synthesis of coumarin-3-carboxylic acid-6'-O-D-sucrose ester derivatives based on flow chemistry

专利号:CN-113024499-A
优先权日:2021-03-17
标 题 :A kind of green synthesis method of coumarin-3-carboxylic acid compounds

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合成参考文献


摘要:Cheng, B.; Wang, T., Science of Synthesis Knowledge Updates, (2020) 3, 159.
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