CAS: 84539-22-0; 4-(5-Bromopyrimidin-2-yl)Morpholine

该化合物是多种多用途有机化合物,具有溴化火烈胺替代成分,具有很高的纯度和稳定性,适合各种合成用途,该化合物独特的结构和电子特性在医药化学方面提供了优势,包括生物利用率和选择性的提高,它与各种反应条件的兼容性进一步扩大了其在研究与开发中的效用.

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相似化合物

663194-10-3 24192-96-9 57356-66-8

物理性质

MSDS等安全信息

欧盟法规

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CAS号110-91-8 吗啉 | CAS号32779-36-5 5-溴-2-氯嘧啶 | CAS号57356-66-8 4-(嘧啶-2-基)吗啉 | CAS号37828-58-3 lithium (3-oxat... | CAS号183438-24-6 5-溴-2-碘嘧啶 | CAS号870521-33-8 2-吗啉基嘧啶-5-基硼酸 | CAS号926009-60-1 4-(5-ethynylpyr...

合成工艺路线路线简述

  • 57356-66-8 = 84539-22-0
    反应条件:1.1 Reagents: Bromine Solvents: Dichloromethane; 1 H,Rt1.2 Reagents: Sodium Carbonate Solvents: Water; 2 H,Rt
    标题:Synthesis Of 5-(Het)Aryl- And 4,5-Di(Het)Aryl-2-(Thio)Morpholinopyrimidines From 2-Chloropyrimidine Via Snh And Cross-Coupling Reactions
    作者:Cheprakova,E. M.; Et Al
    参考文献:Russian Chemical Bulletin 日期:2014 卷标:63(6) 页码:1350-1358]

    183438-24-6 + 37828-58-3 = 84539-22-0
    反应条件:1.1 Reagents: 2,2,6,6-Tetramethylpiperidine,Magnesate(1-),Dichloro(1-Methylethyl)-,Lithium (1:1) Solvents: Tetrahydrofuran; 24 H,25 °C1.2 Solvents: Tetrahydrofuran; 0.5 H,80 °C1.3 Reagents: Lithium Chloride Solvents: Tetrahydrofuran; 1 H,130 °C; 130 °C -> 25 °C1.4 Reagents: Cuprous Chloride; 25 °C -> 130 °C; 5 H,130 °C; 130 °C -> 25 °C1.5 Solvents: Tetrahydrofuran; 6 H,25 °C1.6 Reagents: Triethylamine; 0.7 H,-50 °C1.7 1 H; 1.5 H,-80 °C1.8 Reagents: 4-Chloroaniline Solvents: Tetrahydrofuran; 1 H,-80 °C; 12 H,-80 °C
    标题:Oxidative Amination Of Cuprated Pyrimidine And Purine Derivatives
    作者:Boudet,Nadege; Et Al
    参考文献:Organic Letters 日期:2008 卷标:10(9) 页码:1715-1718]

    128-08-5 + 57356-66-8 = 84539-22-0
    反应条件:1.1 Reagents: Bromine Catalysts: Sodium Bicarbonate
    标题:Bromination Of Some Pyridine And Diazine N-Oxides
    作者:Paudler,William W.; Et Al
    参考文献:Journal Of Organic Chemistry 日期:1983 卷标:48(7) 页码:1064-9]

    1722-12-9 = 84539-22-0
    反应条件:1.1 Reagents: Potassium Carbonate Solvents: Dimethylformamide; 20 Min,Rt1.2 24 H,Rt2.1 Reagents: Bromine Solvents: Dichloromethane; 1 H,Rt2.2 Reagents: Sodium Carbonate Solvents: Water; 2 H,Rt
    标题:Synthesis Of 5-(Het)Aryl- And 4,5-Di(Het)Aryl-2-(Thio)Morpholinopyrimidines From 2-Chloropyrimidine Via Snh And Cross-Coupling Reactions
    作者:Cheprakova,E. M.; Et Al
    参考文献:Russian Chemical Bulletin 日期:2014 卷标:63(6) 页码:1350-1358]

    57356-66-8 = 84539-22-0
    反应条件:1.1 Reagents: Bromine Solvents: Dichloromethane; 30 Min,Rt1.2 Reagents: Sodium Bisulfate Solvents: Water
    标题:4-Amino-5-Aryl-6-Arylethynylpyrimidines: Structure-Activity Relationships Of Non-Nucleoside Adenosine Kinase Inhibitors
    作者:Matulenko,Mark A.; Et Al
    参考文献:Bioorganic & Medicinal Chemistry 日期:2007 卷标:15(4) 页码:1586-1605]

    57356-66-8 = 84539-22-0
    反应条件:1.1 Reagents: Bromine Catalysts: Sodium Bicarbonate
    标题:Bromination Of Some Pyridine And Diazine N-Oxides
    作者:Paudler,William W.; Et Al
    参考文献:Journal Of Organic Chemistry 日期:1983 卷标:48(7) 页码:1064-9]

    4595-59-9 = 84539-22-0
    反应条件:1.1 Solvents: Ethanol; 24 H,Rt2.1 Reagents: Bromine Solvents: Dichloromethane; 30 Min,Rt2.2 Reagents: Sodium Bisulfate Solvents: Water
    标题:4-Amino-5-Aryl-6-Arylethynylpyrimidines: Structure-Activity Relationships Of Non-Nucleoside Adenosine Kinase Inhibitors
    作者:Matulenko,Mark A.; Et Al
    参考文献:Bioorganic & Medicinal Chemistry 日期:2007 卷标:15(4) 页码:1586-1605]

    = 84539-22-0
    反应条件:1.1 Reagents: Butyllithium Solvents: Tetrahydrofuran,Hexane; 30 Min,-40 °C; 5 Min,20 °C2.1 Reagents: 2,2,6,6-Tetramethylpiperidine,Magnesate(1-),Dichloro(1-Methylethyl)-,Lithium (1:1) Solvents: Tetrahydrofuran; 24 H,25 °C2.2 Solvents: Tetrahydrofuran; 0.5 H,80 °C2.3 Reagents: Lithium Chloride Solvents: Tetrahydrofuran; 1 H,130 °C; 130 °C -> 25 °C2.4 Reagents: Cuprous Chloride; 25 °C -> 130 °C; 5 H,130 °C; 130 °C -> 25 °C2.5 Solvents: Tetrahydrofuran; 6 H,25 °C2.6 Reagents: Triethylamine; 0.7 H,-50 °C2.7 1 H; 1.5 H,-80 °C2.8 Reagents: 4-Chloroaniline Solvents: Tetrahydrofuran; 1 H,-80 °C; 12 H,-80 °C
    标题:Oxidative Amination Of Cuprated Pyrimidine And Purine Derivatives
    作者:Boudet,Nadege; Et Al
    参考文献:Organic Letters 日期:2008 卷标:10(9) 页码:1715-1718
📜4-(嘧啶-2-基)吗啉置于溴体系中,用 二氯甲烷 作为反应溶剂,化学反应 1.0H,以89%的收率获得产物5-溴-2-(吗啉-1)嘧啶
参考文献:Synthesis Of 5-(Het)Aryl-And 4,5-Di(Het)Aryl-2-(Thio)Morpholinopyrimidines From 2-Chloropyrimidine Via Sn H And Cross-Coupling Reactions
标题:Synthesis Of 5-(Het)Aryl-And 4,5-Di(Het)Aryl-2-(Thio)Morpholinopyrimidines From 2-Chloropyrimidine Via Sn H And Cross-Coupling Reactions
摘要:研究表明,利用氢的亲核芳香取代反应(sn H),Sn Ipso反应以及微波辅助的铃木交叉耦合反应的各种组合,是一种多功能的合成方法,可用于制备5-(杂)芳基-2-(硫)吗啉基嘧啶和4,5-二(杂)芳基-2-(硫)吗啉基嘧啶衍生物.所有合成的嘧啶在体外对结核杆菌h37Rv均表现出微摩尔浓度水平的活性.
DOI:10.1007/s11172-014-0602-Y

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摘要:Riant, O.; Rout, S. K., Science of Synthesis, (2019) , 35.
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