CAS: 76855-69-1; (2R,3R)-3-((R)-1-((Tert-Butyldimethylsilyl)Oxy)Ethyl)-4-Oxoazetidin-2-Yl Acetate

相似化合物

90776-58-2 85954-95-6 104527-11-9

上下游产品

peracetic acid ethyl>azetidin-2-one(1'R,3S)-3-1'-(tert-butyldimethylsilyl)oxyethylazetidin-2-one trimethylsilyl acetate -4-phenylsulfinylazetidin-2-one(3S,4R)-3-(1R)-1-(tert-Butyldimethylsiloxy)ethyl-4-phenylsulfinylazetidin-2-one -3--2-azetidinone(3S,4S)-4-(1S)-1-benzyloxycarbonylethyl-3-(1R)-1-tert-butyldimethylsilyloxyethyl-2-azetidinone -3--2-azetidinone(3S,4S)-4-(1R)-1-benzyloxycarbonylethyl-3-(1R)-1-tert-butyldimethylsilyloxyethyl-2-azetidinone (3S,4R)-3-((R)-1-(t-butyldimethylsilyloxy)ethyl)-4-triphenylmethylthio-2-azetidinone (3R,4R)-3-(1R-t-butylsilyloxyethyl)-4-(2-phenyl-2-oxo-1,1-difluoro)-azetidin-2-one

在 Sodium Perborate,溶剂黄146,Sodium Acetate体系中,用 溶剂黄146 作为反应溶剂,化学反应 6.0H,以83%的收率获得产物4-乙酰氧基氮杂环丁酮
参考文献:Wo2008/7836
标题:Wo2008/7836

专利信息

专利号:US-4895939-A
优先权日:1986-02-24
标题:High percentage β-yield synthesis of carbapenem intermediates
发明人：MARTEL ALAIN; DARIS JEAN-PAUL; CORBEIL JACQUES
权利人:BRISTOL MYERS CO
摘要:Disclosed herein is a novel high beta -yield producing novel intermediates of the formula where R4 is useful in the synthesis of 1- beta -alkyl carbapenems.

专利号:US-4772683-A
优先权日:1986-02-24
标 题:High percentage beta-yield synthesis of carbapenem intermediates
发明人：MARTEL ALAIN; DARIS JEAN-PAUL; CORBEIL JACQUES
权利人:BRISTOL MYERS CO
摘要:Disclosed herein is a novel process using novel silyl enol ether intermediates of the formula 8 to generate novel azetidione thiolester intermediates of the formula 12 which can be used to form 1- beta -alkyl carbapenem antibiotics. It has now been discovered that if the R4 group is selected from a small group of moieties having the formula: an increased beta -yield of up to approximately 100% can be obtained.

专利号:US-4841043-A
优先权日:1985-12-23
标 题:Stereoselective synthesis of 1-β-alkyl carbapenem antibiotic intermediates
发明人：DEZIEL ROBERT; ENDO MASAKI
权利人:BRISTOL MYERS CO
摘要:There is disclosed a process for producing carbapenam diazo intermediates of the formula ##STR1## wherein R 1 is hydrogen or a hydroxy-protecting group, n R 2 is a lower alkyl having from 1-6 carbon atoms, and n R 3 represents a conventional carboxyl-protecting group. n The processs comprises alkylating a 4-substituted azetidinone with the tin enolate of an α-bromoketone, in the presence of a silver salt, iodine, or iodine salt as a catalyst, and a strongly polar solvent. The β/α yield of the product diazo intermediate is approximately 3/1.

专利号:US-5231179-A
优先权日:1986-01-27
标题 :Heterocyclic compounds and their production
发明人：TERASHIMA SHIRO; ITO YOSHIO; KAWABATA TAKEO; SAKAI KUNIKAZU; HIYAMA TAMEJIRO; KIMURA YOSHIKAZU; SUNAGAWA MAKOTO; TAMOTO KATSUMI; SASAKI AKIRA
权利人:SUMITOMO PHARMA
摘要:A compound of the formula: (I) wherein R1, R2, R3 and R4 are each a hydrogen atom, a lower alkyl group, an ar(lower)alkyl group or an aryl group, or R1 and R2 may be combined together to form a lower alkylene group and/or R3 and R4 are combined together to form a lower alkylene group, or R1, R2, R3 and R4 may be combined together to form an o-phenylene group, X is a halogen atom and Y is an oxygen atom or a nitrogen atom substituted with lower alkyl or aryl, which is useful as an intermediate in the synthesis of 1 beta -methylcarbapenem compounds valuable as antibiotics.

专利号:CN-101367830-B
优先权日:2008-09-28
标题 :Synthesis of sulfomycin derivant

专利号:CN-101367830-A
优先权日:2008-09-28
标 题:Synthesis of sulfomycin derivant