CAS: 7340-90-1; 5-Tert-Butyl-2-Methylthiophenol

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CAS号34493-12-4 1,2-bis(5-(tert...

📜Bis(5-(Tert-Butyl)-2-Methylphenyl)Disulfide置于sodium Tetrahydroborate体系中,化学反应生成 5-叔丁基-2-甲基苯硫酚
参考文献:硫基自由基促进的分子氧意外地催化了c = C键的裂解.
标题:硫基自由基促进的分子氧意外地催化了c = C键的裂解.
摘要:在过渡金属催化剂和苯硫酚的促进下,分子氧对烯烃的氧化作用涉及将c = C键裂解为相应的羰基衍生物.在室温下,在过量的硫酚和催化剂(例如mnl(2)3A或vcll(2)3C)的存在下,该新反应在一种氧气气氛下于室温进行.它可用于芳族和脂族烯烃,以及官能化或非官能化的无环化合物,以高达98%的收率提供相应的酮和醛.通过一步制备芳香族(-)-4-乙酰基-1-甲基环己烯7E的一步制备方法可以说明这种催化氧化的合成兴趣,分离出的收率为73%.c = C键的断裂可能是由于β-氢过氧硫化物中间体12的催化分解而造成的,该中间体是通过在氧气存在下将硫酚自由基加成至烯烃而形成的.尽管使用了过量的硫酚,但仍将其转化为二硫化物,然后无需纯化即可将其还原,总收率为83%,从而可以回收利用.另外,通过二硫化物的光解产生的催化量的噻吩基可以促进在氧下的c = C键裂解.因此,在0.1当量的双(4-氯苯基)二硫化物4B
DOI:10.1021/jo0013148

专利信息

专利号:US-2014234364-A1
优先权日:2011-09-23
标 题:Total synthesis and immunological evaluation of saccharide moieties of the lipopolysaccharide from neisseria meningitidis
发明人：SEEBERGER PETER H; YANG YOU; ANISH CHAKKUMKAL; REINHARDT ANIKA
权利人:MAX PLANCK GES ZUR FÖRDERUNG DER WISSENSCHAFTEN E V
摘要:The present invention relates to the total chemical synthesis of the monosaccharide 35 # (R′â•?H), the disaccharide 36 # (R′≠H; R″â•?H), the trisaccharide 37 # (R′≠H; R″≠H; R′″≠H) and the tetrasaccharide 1 # (R′≠H; R″≠H; R′″≠H) of the following general formula wherein R represents —Y—NH 2 Y represents a linker R′ is H or R″ is H or R′″ is H or of the lipopolysaccharide from Neisseria meningitidis , as well as to the trisaccharide 37 # and the tetrasaccharide 1 # , to vaccines containing at least one of the saccharides 1 # , 35 # , 36 # , and 37 # and to the use of such vaccine for immunization against diseases caused by infection with bacteria containing the tetrasaccharide α-GlcNAc-(1→2)-α-Hep-( 1→3 )-α-Hep-(1→5)-α-Kdo or the trisaccharide α-Hep-(1→3)-α-Hep-(1→5)-α-Kdo or α-GlcNAc-(1→2)-±-Hep-(1→3)-α-Hep, especially for immunization against meningitis, septicaemia, pneumonia and nasopharyngitis caused by Neisseria meningitidis.

专利号:EP-2609107-B1
优先权日:2010-08-23
标题 :Block synthesis of oligoribonucleotides
发明人：DAMHA MASAD J; HASSLER MATTHEW; CHAN TAK-HANG; NANDYALA MALLIKARJUNA REDDY; DONGA ROBERT ALEXANDER
权利人:THE ROYAL INSTITUTION FOR THE ADVANCEMENT OF LEARNING / MCGILL UNIV

专利号:CA-2844769-A1
优先权日:2010-08-23
标题 :Block synthesis of oligoribonucleotides

专利号:US-9238669-B2
优先权日:2011-08-02
标题 :Oligosaccharides and oligosaccharide-protein conjugates derived from Clostridium difficile polysaccharide PS-I, methods of synthesis and uses thereof, in particular as vaccines and diagnostic tools
发明人：SEEBERGER PETER H; MARTIN CHRISTOPHER E; BROECKER FELIX; ANISH CHAKKUMKAL
权利人:SEEBERGER PETER H; MARTIN CHRISTOPHER E; BROECKER FELIX; ANISH CHAKKUMKAL; MAX PLANCK GESELLSCHAFT
摘要:The invention relates to a synthetic oligosaccharide representing part of the repeating unit of the Clostridium difficile glycopolymer PS-I and having the sequence of the pentasaccharide a-L-Rhap-(1→3)-β-D-Glcp-(1→4)-[a-L-Rhap-(1→3]-a-D-Glcp-(1→2)-a-D-Glcp or a synthetic fragment or derivative thereof. Preferably, the claimed synthetic oligosaccharide bears at least one linker L for conjugation to a carrier protein or for immobilization on a surface. Further aspects of the invention relate to advantageous methods for synthesizing said synthetic oligosaccharide and oligosaccharide-protein conjugate as well as to uses thereof, in particular as vaccines and diagnostic tools.

专利号:WO-2012024776-A1
优先权日:2010-08-23
标题:Block synthesis of oligoribonucleotides

专利号:SG-188289-A1
优先权日:2010-08-23
标题:Block synthesis of oligoribonucleotides