CAS: 693-25-4; Pentylmagnesium Bromide

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CAS号26878-13-7 2-氧代-2-(2-噻吩基)乙酸甲酯 | CAS号110-53-2 1-溴戊烷 | CAS号1071-26-7 2,2-二甲基庚烷 | CAS号1001-48-5 methyl(dipentyl... | CAS号10496-10-3 tripentylphosphane | CAS号736137-64-7 4-methyl-2-[(5-... | CAS号112283-13-3 6-十七醇 | CAS号821-09-0 4-戊烯-1-醇 | CAS号57074-37-0 (Z)-4-癸烯-1-醇 | CAS号57661-23-1 6-十六酮 | CAS号4737-50-2 正戊基硼酸 | CAS号35161-70-7 N-甲基己胺

1-溴戊烷置于magnesium体系中,用 四氢呋喃 作为反应溶剂,化学反应生成 正戊基溴化镁
参考文献:格氏试剂形成的选择性:从半批量到连续实验室和中试规模
标题:格氏试剂形成的选择性:从半批量到连续实验室和中试规模
摘要:由金属镁和卤化物形成格氏试剂通常伴随着wurtz偶联产物的形成,这是格氏试剂分子与卤化物分子反应形成的不需要的副产物.通过对各种格氏试剂采用从半间歇式合成到连续实验室和中试规模的放大方法,证明连续生产工艺可以提高格氏试剂选择性并减少wurtz偶联.
DOI:10.1021/acs.Oprd.3C00305

专利信息

专利号:US-9212118-B2
优先权日:2010-12-23
标题:Synthesis of intermediates for preparing anacetrapib and derivatives thereof
发明人：HUMLJAN JAN; MARAS NENAD
权利人:HUMLJAN JAN; MARAS NENAD; LEK PHARMACEUTICALS
摘要:The present invention relates to the field of organic chemistry, more specifically to the synthesis of intermediate compounds which can be used in the synthesis of pharmaceutically active agents such as anacetrapib or derivatives thereof.

专利号:US-10000432-B2
优先权日:2014-01-13
标 题 :Processes for the synthesis of chiral 1-alkanols
发明人：NEGISHI EI-ICHI
权利人:PURDUE RESEARCH FOUNDATION
摘要:The invention relates to highly enantioselective processes for the synthesis of chiral 1-alkanols via Zr-catalyzed asymmetric carboalumination of alkenes.

专利号:US-12264143-B2
优先权日:2020-12-17
标 题:Synthesis of cannabinoids and cannabinoid precursors, and related compounds, formulations, and methods of use
发明人：SAMMIS GLENN M; ROGGEN MARKUS
权利人:NALU BIO INC
摘要:Methods are provided for the synthesis of cannabinoids, including cannabidiol (CBD), cannabinol (CBN), cannabichromene (CBC), cannabidiolic acid (CBDA), cannabigerol (CBG), cannabigerolic acid (CBGA), cannabidivarin (CBDV), cannabidibutol (CBD-C4), dihydrocannabidiol (DCBD), tetrahydrocannabivarin (THCV), analogs thereof, and precursors to the foregoing. One method employs phloroglucinol or a phloroglucinol analog as a starting material. The syntheses are stereospecific, efficient, selective, and cost-effective, with little or no potential for generation of THC ((−)-trans-Δ9-tetrahydro-cannabinol) or any other psychoactive side product. Telescoped syntheses are also provided, as are new cannabinoids, pharmaceutical formulations, and methods of use.

专利号:US-4922049-A
优先权日:1989-01-13
标 题:Synthesis of cis-olefins
发明人：BYERS JIM D
权利人:PHILLIPS PETROLEUM CO
摘要:A process for the synthesis of cis-olefins from cis-olefinic alcohols consisting essentially of the following steps: n (a) reacting a cis-olefinic alcohol with a source of an alkali metal ion selected from the group consisting of lithium and sodium ions to form a first reaction product, n (b) then contacting said thus formed first reaction product with a sulfonyl halide compound to form a second reaction product, n (c) then containing said thus formed second reaction product with an alkyl magnesium compound and a cuprous salt to form a third reaction product comprising a cis-olefin wherein said steps are carried out in a suitable organic solvent.

专利号:WO-2023237381-A1
优先权日:2022-06-09
标题:Process for the synthesis of polyethylenes or copolymers of ethylene and 1,3-diene having a terminal ketone function
发明人：BOISSON CHRISTOPHE; D'AGOSTO FRANCK; DESGRANGES ARIANE; NGO ROBERT; JEAN-BAPTISTE-DIT-DOMINIQUE FRANÇOIS
权利人:MICHELIN & CIE; CENTRE NAT RECH SCIENT; ECOLE SUPERIEURE DE CHIMIE PHYSIQUE ELECTRONIQUE LYON; UNIV CLAUDE BERNARD LYON
摘要:The invention relates to a method for preparing a polyethylene having a terminal ketone function or a copolymer of ethylene and a 1,3-diene and optionally a vinyl aromatic compound which contains more than 50 mol% of ethylene and has a terminal ketone function; said method comprises a polymerization reaction of the monomers in the presence of a borohydrido-neodymocene complex and an organo-magnesium compound, followed by a coupling reaction with a compound having a nitrile function, and then a hydrolysis reaction.

专利号:US-11926577-B2
优先权日:2020-10-09
标题:Method for synthesis of 2-methyl-2-hydroxyheptane and 2-methyl 2-alkoxyheptanes
发明人：FOLEY PATRICK; YANG YONGHUA; TU YONG
权利人:P2 SCIENCE INC
摘要:The present disclosure pertains to a new synthetic method for the preparation of 2-methyl-2-hydroxyheptane and 2-methyl-2-alkoxyheptanes, which are valuable commodities for use in flavors, fragrances and various personal care products, such as cosmetics.