CAS: 588-42-1; Trolnitrate Phosphate

专利信息

专利号:US-10925977-B2
优先权日:2006-10-05
标 题 :Efficient synthesis of chelators for nuclear imaging and radiotherapy: compositions and applications
发明人：YANG DAVID J; YU DONGFANG; THOMPSON ANDREW S
权利人:YANG DAVID J; YU DONGFANG; THOMPSON ANDREW S; CEIL POINT LLC; UNIV TEXAS
摘要:Novel methods of synthesis of chelator-targeting ligand conjugates, compositions comprising such conjugates, and therapeutic and diagnostic applications of such conjugates are disclosed. The compositions include chelator-targeting ligand conjugates optionally chelated to one or more metal ions. Methods of synthesizing these compositions in high purity are also presented. Also disclosed are methods of imaging, treating and diagnosing disease in a subject using these novel compositions, such as methods of imaging a tumor within a subject and methods of diagnosing myocardial ischemia.

专利号:WO-2017033128-A1
优先权日:2015-08-25
标题 :Biphenyl-substitued 4-amino-butyric acid derivatives and their use in the synthesis of nep inhibitors
发明人：HOOK DAVID; KU JIE; ZHOU JIANGUANG
权利人:NOVARTIS AG; HOOK DAVID; KU JIE; ZHOU JIANGUANG
摘要:The invention relates to a novel process, novel process steps and novel intermediates useful in the synthesis of pharmaceutically active compounds, in particular neutral endopeptidase (NEP) inhibitors and prodrugs thereof.

专利号:US-8309099-B2
优先权日:2000-04-28
标 题:DNA transfection system for the generation of negative strand RNA virus
发明人：HOFFMANN ERICH
权利人:HOFFMANN ERICH; ST JUDE CHILDRENS RES HOSPITAL
摘要:The present invention is based on the development of a dual promoter system (preferably a RNA pol I-pol II system) for the efficient intracellular synthesis of viral RNA. The resultant minimal plasmid-based system may be used to synthesize any RNA virus, preferably viruses with a negative single stranded RNA genome. The viral product of the system is produced when the plasmids of the system are introduced into a suitable host cell. One application of the system is production of attenuated, reassortant influenza viruses for use as antigens in vaccines. The reassortant viruses generated by cotransfection of plasmids may comprise genes encoding the surface glycoproteins hemagglutinin and neuraminidase from an influenza virus currently infecting the population and the internal genes from an attenuated influenza virus. An advantageous property of the present invention is its versatility; the system may be quickly and easily adapted to synthesize an attenuated version of any RNA virus. Attenuated or inactivated RNA viruses produced by the present invention may be administered to a patient in need of vaccination by any of several routes including intranasally or intramuscularly.

专利号:US-2006057069-A1
优先权日:2004-06-07
标 题 :Detection of protein expression in vivo using fluorescent puromycin conjugates
发明人：STARCK-GREEN SHELLEY R; GREEN HARRY M; ALBEROLA-ILA JOSE; ROBERTS RICHARD W; SCHUMAN ERIN; SMITH WILLIAM B; HAY BRUCE A
权利人:CALIFORNIA INST OF TECHN
摘要:Disclosed is a class of reagents for examining protein expression in vivo that does not require transfection, radiolabeling, or the prior choice of a candidate gene. Further, a series of puromycin conjugates was constructed bearing various labeling moieties. These conjugates were readily incorporated into expressed protein products in cell lysates in vitro and efficiently cross cell membranes to function in protein synthesis in vivo as indicated by flow cytometry, selective enrichment studies, and western analysis. The present invention demonstrates that labeled-puromycin conjugates offer a general means to examine protein expression in vivo.

专利号:WO-2020239822-A1
优先权日:2019-05-27
标题 :Nucleic acid construct binding to influenza polymerase pb1 rna synthesis active site
发明人：CUSACK STEPHEN; DRNCOVA PETRA; KOUBA TOMAS
权利人:THE EUROPEAN MOLECULAR BIOLOGY LABORATORY
摘要:The present invention relates to a new nucleic acid construct capable of binding to the PB1 RNA synthesis active site of influenza polymerase. The nucleic acid construct allows capturing the structure of the transcription initiation state of influenza polymerase. The present invention further pertains to methods for obtaining images or crystallography data on an influenza polymerase in a functional or active state, methods for identifying, selecting or designing a compound which inhibits influenza RNA polymerase, and to such compounds per se. Further provided are pharmaceutical compositions comprising such compounds and the compounds or pharmaceutical compositions for use in treating, ameliorating, or preventing a disease caused by viral infections with negative-sense single stranded RNA viruses.

专利号:WO-2005075639-A1
优先权日:2004-02-06
标 题:Method of constructing glycoprotein by using extension codon
发明人：NISHIMURA SHINICHIRO; SADAMOTO REIKO; MATSUBARA NAOKI; NIIKURA KENICHI
权利人:SHIONOGI & CO; NISHIMURA SHINICHIRO; SADAMOTO REIKO; MATSUBARA NAOKI; NIIKURA KENICHI
摘要:It is intended to provide a method for forming a glycopeptide whereby a sugar chain can be conveniently transferred. This object can be achieved by transferring an amino acid, wherein a group for transferring a sugar chain is blocked, into a protein by the four base codon method, then deblocking and transferring a natural sugar chain into this site. That is, a method for producing a protein containing an amino acid having a functional group capable of binding to a sugar chain which comprises: (a) the step of providing a modified tRNA containing an amino acid having a functional group capable of binding to a sugar chain and recognizing a four base codon; (b) the step of providing a modified nucleic acid molecule containing a nucleic acid sequence containing the four base codon or its complementation; (c) the step of transcribing the modified nucleic acid molecule to form an mRNA; and (d) the step of exposing the mRNA to a protein synthesis system containing the modified tRNA and a tRNA set required in translation to thereby form a protein.