CAS: 443-69-6; 5-Fluoroindoline-2,3-Dione

上下游产品

CAS号879274-72-3 (E)-N-(4-fluoro... | CAS号515-83-3 2,2,2-三氯-1-乙氧基乙醇 | CAS号371-40-4 4-氟苯胺 | CAS号351-09-7 对氟异亚硝基乙酰苯胺 | CAS号20780-76-1 5-碘靛红 | CAS号79-37-8 草酰氯 | CAS号302-17-0 水合氯醛 | CAS号113423-50-0 3,3-dibromo-5-f... | CAS号1003-98-1 2-溴-4-氟苯胺 | CAS号452105-33-8 5-[(Z)-(5-Fluor... | CAS号321-69-7 5-氟靛红酸酐 | CAS号341031-54-7 苹果酸舒尼替尼 | CAS号1158178-12-1 5-fluoro-3'-p-t... | CAS号32212-38-7 2-氨基-N-对甲苯苯甲酰胺 | CAS号557795-19-4 舒尼替尼 | CAS号446-08-2 2-氨基-5-氟苯甲酸 | CAS号485841-48-3 5-氟-1H-吲唑-3-甲醛 | CAS号220844-73-5 6-氟-喹啉-4-羧酸 | CAS号78155-73-4 5-氟-1H-吲唑-3-羧酸甲酯

5-氟吲哚啉置于2-亚碘酰基苯甲酸,氧气体系中,用 二甲基亚砜 作为反应溶剂,化学反应 12.0H,以72%的收率获得产物5-氟靛红
参考文献:碘代苯甲酸 (Iba) 催化的苄基和芳族 C-H 氧化
标题:碘代苯甲酸 (Iba) 催化的苄基和芳族 C-H 氧化
摘要:摘要 采用一种不含金属的可重复使用的高价碘 (Iii) 试剂作为稳定的催化剂,用于将活性亚甲基,吲哚和苯乙烯的 C-H 键选择性氧化为相应的羰基化合物.从经济和环境的角度来看,使用 2-碘代苯甲酸代替金属进行氧化,使反应变得有趣.图形摘要一种无金属可重复使用的高价碘 (Iii) 试剂被用作活性亚甲基选择性氧化的稳定催化剂,吲哚和苯乙烯 C-H 键合到相应的羰基化合物上.从经济和环境的角度来看,使用氧气作为氧化剂,使反应变得有趣.
DOI:10.1007/s10562-017-2050-4

专利信息

专利号:WO-2016147205-A1
优先权日:2015-03-13
标题 :Novel substituted 3-spirophosphoryl pyrazole-2-oxindoles as anti-infectives and process for the synthesis thereof
发明人：SURYAVANSHI GURUNATH MALLAPPA; SHELKE ANIL MARUTI
权利人:COUNCIL SCIENT IND RES
摘要:The present invention relates to novel substituted 3-spirophosphoryl, pyrazole-2-oxindoles of Formula (I) and its pharmaceutically acceptable salts, esters, ethers, isomers, stereoisomers, positional isomers and pplymorphs. The present invention further relates to one pot, one step process for the synthesis of spirophosphoiyl pyrazole oxindoles of Formula (I) with yield in the range of 70-85%.

专利号:WO-9948868-A9
优先权日:1998-03-26
标 题 :Heterocyclic classes of compounds for the modulating tyrosine protein kinase
发明人：FONG ANNIE; HANNAH ALISON; HARRIS G DAVIS; HIRTH PETER; HUBBARD STEVEN R; LANGECKER PETER; LIANG CONGXIN; MCMAHON GERALD; MOHAMMADI MOOSA; SCHLESSINGER JOSEPH; SHAWVER LAURA K; SUN LI; TANG PENG C; ULLRICH AXEL
权利人:SUGEN INC; UNIV NEW YORK; MAX PLANCK INST FUR BIOCHEMIE; FONG ANNIE; HANNAH ALISON; HARRIS G DAVIS; HIRTH PETER; HUBBARD STEVEN R; LANGECKER PETER; LIANG CONGXIN; MCMAHON GERALD; MOHAMMADI MOOSA; SCHLESSINGER JOSEPH; SHAWVER LAURA K; SUN LI; TANG PENG C; ULLRICH AXEL
摘要:The invention relates to certain indolinone-based and pyrazolylamide-based compounds, their method of synthesis, and combinatorial libraries consisting of the compounds. The invention also relates to methods of modulating the function of protein kinases using these compounds and methods of treating diseases by modulating the function of protein kinases and related signal transduction pathways.

专利号:WO-0053313-A2
优先权日:1999-03-09
标 题:Lanthanide catalysts for synthesis of compounds and combinatorial libraries

专利号:US-8497296-B2
优先权日:2011-03-31
标 题:N,N′-hydrazino-bis-isatin derivatives with selective activity against multidrug-resistant cancer cells
发明人：HASSAN TAREK ABOUL-FADL MOHAMED; KADI ADNAN AHMED; ABDEL-AZIZ HATEM ABDEL-KHADER
权利人:HASSAN TAREK ABOUL-FADL MOHAMED; KADI ADNAN AHMED; ABDEL-AZIZ HATEM ABDEL-KHADER; UNIV KING SAUD
摘要:The invention is directed to a compound of Formula (I), n nwherein R is selected from the group consisting of hydrogen atom and unsubstituted or substituted phenyl group; R 1 is selected from the group consisting of hydrogen atom and unsubstituted or substituted phenyl group; X is selected from the group consisting of hydrogen atom or halogen atom; and Y is selected from the group consisting of hydrogen atom, halogen atom, C 1 -C 4 alkyl group, nitro group, and —OCF 3 group, as well as for its use in therapy, preferably for the treatment of cancer, and to a related pharmaceutical composition, the use of the compound for the manufacture of a medicament for the respective medical indication, and a method of synthesis of the compounds of the invention.

专利号:US-8933248-B2
优先权日:2012-06-21
标 题:3-substituted-3-hydroxy oxindole derivatives and process for preparation thereof
发明人：RAO MANDAPATI MOHAN; PRATHIMA PARVATHANENI SAI
权利人:COUNCIL SCIENT IND RES
摘要:The present invention relates to expedient method for synthesis of 3-substituted-3-hydroxy-oxindole derivatives, which are useful as synthetic precursors to valuable pharmaceutical compounds. These are synthesized by reacting nitromethane with the corresponding isatins of formula (I). The reaction process of isatins was carried using water as a solvent at room temperature to form the corresponding 3-hydroxy-3-nitromethylindolin-2-ones of formula (II).

专利号:US-10077255-B2
优先权日:2010-04-06
标题:Synthesis of chiral 2-(1H-indazol-6-yl)-spiro[cyclopropane-1,3′-indolin]-2′-ones