CAS: 3977-23-9; 2-Imino-5,6-Dimethyl-2,3-Dihydropyrimidin-4(1H)-One

相似化合物

37893-08-6 28224-69-3 500115-86-6

上下游产品

CAS号609-14-3 2-甲基乙酰乙酸乙酯 | CAS号594-14-9 硫酸胍 | CAS号593-85-1 碳酸胍 | CAS号14394-61-7 2-氨基-4-氯-5,6-二甲基嘧啶

📜2-甲基-3-氧代丁酸甲酯,盐酸胍置于potassium Tert-Butylate体系中,用 甲醇 用作溶剂,化学反应生成2-氨基-5,6-二甲基-4-羟基嘧啶
参考文献:Discovery And Sar Of 6-Alkyl-2,4-Diaminopyrimidines As Histamine H4 Receptor Antagonists
标题:Discovery And Sar Of 6-Alkyl-2,4-Diaminopyrimidines As Histamine H4 Receptor Antagonists
摘要:This Report Discloses The Discovery And Sar Of A Series Of 6-Alkyl-2-Aminopyrimidine Derived Histamine H4 Antagonists That Led To The Development Of Jnj 39758979,Which Has Been Studied In Phase Ii Clinical Trials In Asthma And Atopic Dermatitis. Building On Our Sar Studies Of Saturated Derivatives From The Indole Carboxamide Series,Typified By Jnj 7777120,And Incorporating Knowledge From The Tricyclic Pyrimidines Led Us To The 6-Alkyl-2,4-Diaminopyrimidine Series. A Focused Medicinal Chemistry Effort Delivered Several 6-Alkyl-2,4-Diaminopyrimidines That Behaved As Antagonists At Both The Human And Rodent H4 Receptor. Further Optimization Led To A Panel Of Antagonists That Were Profiled In Animal Models Of Inflammatory Disease. On The Basis Of The Preclinical Profile And Efficacy In Several Animal Models,Jnj 39758979 Was Selected As A Clinical Candidate; However,Further Development Was Halted During Phase Ii Because Of The Observation Of Drug-Induced Agranulocytosis (Diag) In Two Subjects.
Doi:10.1021/jm401727M

专利信息

专利号:US-8809553-B2
优先权日:2010-06-15
标题:Process for the preparation of pteridine derivatives
发明人：ATTOLINO EMANUELE; MICHIELETTI MARIO; ROSSI DAVIDE; ALLEGRINI PIETRO
权利人:ATTOLINO EMANUELE; MICHIELETTI MARIO; ROSSI DAVIDE; ALLEGRINI PIETRO; DIPHARMA FRANCIS SRL
摘要:The application discloses a process for the preparation of 5-deoxy-L-arabinose of formula (VI); comprising the conversion of a compound of formula (XII); wherein n is 0, 1 or 2; which can be used as intermediate for the synthesis of sapropterin.

专利号:US-2020181319-A1
优先权日:2016-07-27
标题:Method of regioselective synthesis of polyesters from asymmetric diols

专利号:EP-3018206-A1
优先权日:2005-12-01
标题:Enzymatic encoding methods for efficient synthesis of large libraries

专利号:CN-111850596-A
优先权日:2020-07-13
标题:A kind of continuous production method of electrochemical synthesis of sebacate compounds

专利号:WO-2014149073-A1
优先权日:2013-03-15
标 题:Methods of manufacture and synthesis of amino acid linking groups conjugated to compounds used for targeted imaging of tumors

专利号:US-11137242-B2
优先权日:2016-06-01
标 题:Conductive fiber comprising metal nanobelt and carbon nanomaterial composite, method for producing conductive fiber, fibrous strain sensor, and method for producing fibrous strain sensor
发明人：HAN JOONG TARK; LEE GEON WOONG; SEO SEON HEE; JANG JEONG IN; JEONG SEUNG YOL; JEONG HEE JIN
权利人:KERI KOREA ELECTROTECHNOLOGY RES INST
摘要:A conductive fiber including a metal-nanobelt-carbon-nanomaterial composite. A manufacturing method thereof includes preparing a composite including a carbon nanomaterial and metal nanobelts and manufacturing a conductive fiber by mixing the composite with a polymer. A fibrous strain sensor and a manufacturing method thereof are also provided. Thereby, a conductive fiber including a metal-nanobelt-carbon-nanomaterial composite, which is able to increase conductivity of the conductive fiber through synthesis of metal nanobelts enabling area contact and to exhibit good contact between the carbon nanomaterial and the metal nanobelts due to formation of the metal nanobelts on the surface of the carbon nanomaterial and superior dispersion uniformity, and a fibrous strain sensor including the conductive fiber can be obtained. The conductive fiber can be effectively applied to a strain sensor based on a principle by which resistance drastically increases with an increase in a distance between metal nanobelts aligned in a fiber direction upon tensile strain of metal nanobelts enabling area contact.