CAS: 38647-10-8; Tripdiolide

上下游产品

triptolide (18),8,11,13-tetraene14-methoxy-19-norabieta-4(18),8,11,13-tetraene (3bR,9bS,11S)-7-isopropyl-6-methoxy-11-(methoxymethoxy)-9b-methyl-3b,4,5,9b,10,11-hexahydrophenanthro[2,1-c]furan-1(3H)-one (3bR,5r,9bS,11S)-5-hydroxy-7-isopropyl-6-methoxy-11-(methoxymethoxy)-9b-methyl-3b,4,5,9b,10,11-hexahydrophenanthro[2,1-c]furan-1(3H)-one

📜(4As,10Ar)-7-Isopropyl-8-Methoxy-4A-Methyl-1-Methylene-3,4,4A,9,10,10A-Hexahydrophenanthren-2(1H)-One置于吡啶,甲醇,Oxone,Potassium Fluoride,Sodium Chlorite,Sodium Tetrahydroborate,Sodium Periodate,N-溴代丁二酰亚胺(Nbs),重铬酸吡啶,氯化亚砜,Ammonium Cerium (Iv) Nitrate,Sodium Dihydrogenphosphate Dihydrate,2-甲基-2-丁烯,Tris(6,6,7,7,8,8-Heptafluoro-2,2-Dimethyl-3,5-octadionato)Europium(III),1,1,1-三氟丙酮,水,双氧水,Edetate Disodium,三溴化硼,碳酸氢钠,Potassium Carbonate,Potassium Hydrogencarbonate,戴斯-马丁氧化剂,N,N-二异丙基乙胺,Sodium Hydroxide体系中,用 四氢呋喃,甲醇,二氯甲烷,水,丙酮,乙腈,叔丁醇 用作溶剂,化学反应 38.25H,反应生成雷公藤乙素,(1S,2S,4S,5S,7R,8S,9S,11S,13S,19S)-8,19-Dihydroxy-1-Methyl-7-Propan-2-Yl-3,6,10,16-Tetraoxaheptacyclo[11.7.0.02,4.02,9.05,7.09,11.014,18]Icos-14(18)-En-17-One
参考文献:First Total Synthesis Of Tripdiolide
标题:First Total Synthesis Of Tripdiolide
摘要:The First Total Synthesis Of Tripdiolide 1 From The Readily Available Abietic Acid 3 In 22 Steps Is Described And This Synthesis Furnishes A 5.8% Overall Yield Of 1 With An Average Yield Of 87%. (C) 2010 Elsevier Ltd. All Rights Reserved.
Doi:10.1016/j.Tet.2010.12.014

专利信息

专利号:WO-9411382-A1
优先权日:1992-11-09
标题 :Antineoplastic heteronaphthoquinones
发明人：ATTARDO GIORGIO; BREINING TIBOR; COURCHESNE MARC; KRAUS JEAN-LOUIS; LAMOTHE SERGE; LAVALLEE JEAN-FRANCOIS; LEBEAU ELAINE; NGUYEN DIEU; REJ RABINDRA; ST-DENIS YVES; WANG WUYI; XU YAO-CHANG; BARBEAU FRANCE
权利人:IAF BIOCHEM INT; ATTARDO GIORGIO; BREINING TIBOR; COURCHESNE MARC; KRAUS JEAN LOUIS; LAMOTHE SERGE; LAVALLEE JEAN FRANCOIS; LEBEAU ELAINE; NGUYEN DIEU; REJ RABINDRA; ST DENIS YVES; WANG WUYI; XU YAO CHANG; BARBEAU FRANCE
摘要:Tricyclic heteronaphthoquinone derivatives, that have antineoplastic activity, are disclosed, together with processes for their synthesis. Some of these anti-neoplastics compounds have a saccharide moiety. Some members of this structurally distinct group exhibit activity against multiple drug resistant cancer cells.