CAS: 270596-41-3; (S)-3-Amino-4-(4-Chlorophenyl)Butanoic Acid

上下游产品

4-chlorophenylacetic Acid 5-[2-(4-chlorophenyl)-1-hydroxyethylidene]-2,2-dimethyl-1,3-dioxane-4,6-dione N-(9-fluorenylmethyloxycarbonyl)-L-β-homo-p-chlorophenylalanine

📜5-[2-(4-Chlorophenyl)-1-Hydroxyethylidene]-2,2-Dimethyl-1,3-Dioxane-4,6-Dione置于盐酸,Sodium Tetrahydroborate,乙醇体系中,用 甲醇,乙腈 用作溶剂,化学反应生成(S)-3-氨基-4-(4-氯苯基)-丁酸盐酸盐
参考文献:一种手性β-氨基酸的手性合成方法及医药中 间体的合成方法
标题:一种手性β-氨基酸的手性合成方法及医药中 间体的合成方法
摘要:本发明涉及一种手性β‑氨基酸的手性合成方法,其包括如下步骤:在碱的作用下,式(ⅱ)化合物与酰基化试剂反应制得酸酐中间体反应液;向所述的酸酐中间体反应液中加入米氏酸,反应生成式(ⅲ)化合物;将所述的式(ⅲ)化合物与式(ⅳ)化合物反应生成式(ⅴ)化合物;所述的式(ⅴ)化合物经还原生成式(ⅵ)化合物;所述的式(ⅵ)化合物经酸性水解生成式(ⅰ)化合物所示的手性β‑氨基酸.本发明具有合成方便,成本低,工艺简单的优点,较现已经公布的制备方法更适于工业化生产.

专利信息

专利号:US-2022243244-A1
优先权日:2019-10-10
标 题 :Compositions and methods for in vivo synthesis of unnatural polypeptides
发明人：ROMESBERG FLOYD E; FISCHER EMIL C; HASHIMOTO KOJI; FELDMAN AARON W; DIEN VIVIAN T; ZHANG YORKE
权利人:SCRIPPS RESEARCH INST
摘要:Disclosed herein are compositions, methods, and kits for a cell incorporating unnatural amino acids into an unnatural polypeptide. Also disclosed herein are compositions, methods, and kits for increasing activity and yield of the unnatural polypeptide synthesized by the cell.

专利号:US-2023037284-A9
优先权日:2018-11-30
标题:Combination therapy of peptidomimetic macrocycles
发明人：GUERLAVAIS VINCENT; ANNIS DAVID ALLEN
权利人:AILERON THERAPEUTICS INC
摘要:The present disclosure describes the synthesis of peptidomimetic macrocycles and methods of using peptidomimetic macrocycles to treat a condition. The present disclosure also describes methods of using peptidomimetic macrocycles in combination with at least one additional pharmaceutically-active agent for the treatment of a condition, for example, cancer.

专利号:US-2025084410-A1
优先权日:2015-01-12
标 题:Incorporation of unnatural nucleotides and methods thereof
发明人：PTACIN JEROD; MALYSHEV DENIS A; CAFFARO CAROLINA E
权利人:SYNTHORX INC
摘要:Disclosed herein are methods, compositions and kits for the synthesis of proteins which comprises unnatural amino acids that utilize a mutant tRNA.

专利号:US-2018371021-A1
优先权日:2017-05-11
标 题 :Peptidomimetic macrocycles and uses thereof
发明人：AIVADO MANUEL; GUERLAVAIS VINCENT; OLSON KAREN
权利人:AILERON THERAPEUTICS INC
摘要:The present disclosure describes the synthesis of peptidomimetic macrocycles and methods of using peptidomimetic macrocycles to treat a condition. The present disclosure also describes methods of using peptidomimetic macrocycles in combination with at least one additional pharmaceutically-active agent for the treatment of a condition, for example, cancer.

专利号:CN-107501112-B
优先权日:2017-09-15
标 题:A kind of Chiral Synthesis of chiral beta-amino acids and the synthetic method of medicine intermediate

专利号:WO-2021072167-A1
优先权日:2019-10-10
标 题:Compositions and methods for in vivo synthesis of unnatural polypeptides