CAS: 2206-26-0; 2,2,2-Trideuterioacetonitrile

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CAS号35496-73-2 3-chloro-3-meth... | CAS号75-05-8 乙腈 | CAS号114658-79-6 2-(Methylazo-)p... | CAS号102538-51-2 [(η5-C5Me5)Ru(C... | CAS号275-51-4 甘菊蓝 | CAS号498-66-8 降冰片烯 | CAS号474056-02-5 [Ru(CD3CN)(norb... | CAS号1212-08-4 S-苯基硫代苯基砜 | CAS号1208-20-4 Benzenesulfinot... | CAS号114533-13-0 N-benzyl-[C-2H3... | CAS号100-51-6 苯甲醇 | CAS号724466-85-7 N-(tert-butyl)a...

乙腈置于ru-Macho,Potassium Tert-Butylate,重水体系中,化学反应 24.0H,反应生成氘代乙腈
参考文献:钌催化使用d 2 O †的脂肪族腈选择性α-氘代
标题:钌催化使用d 2 O †的脂肪族腈选择性α-氘代
摘要:报道了使用氧化氘作为氘源的脂族腈的选择性催化α-氘代.Pnp-钌夹杂物催化包括乙腈在内的脂肪腈的α-氘代.在较低的催化剂负载量(0.2至0.5 Mol%)和温和条件下,发生了有效的氘化.由腈官能团和去质子化的催化中间体形成[2 + 2]环加合物,然后亚胺-烯胺互变异构和烯胺中间体与氘化氢之间的h / D交换导致在腈α位的选择性氘化被提出为合理的反应机理.
Doi:10.1039/c8Cc03971B

专利信息

专利号:US-9920084-B2
优先权日:2011-08-23
标题 :Ionic tags for synthesis of oligoribonucleotides
发明人：DAMHA MASAD J; HASSLER MATTHEW; CHAN TAK-HANG; NANDYALA MALLIKARJUNA REDDY; DONGA ROBERT ALEXANDER
权利人:DAMHA MASAD J; HASSLER MATTHEW; CHAN TAK HANG; NANDYALA MALLIKARJUNA REDDY; DONGA ROBERT ALEXANDER; THE ROYAL INSTITUTION FOR THE ADVANCEMENT OF LEARNING/MCGILL UNIV; HONG KONG POLYTECHNIC UNIV
摘要:The invention relates to the chemical synthesis of oligonucleotides, e.g., oligoribonucleotides. In another aspect, the invention relates to compounds of formula (II) processes for making these compounds, and the use thereof in the chemical synthesis of oligonucleotides, e.g., oligoribonucleotides. The invention also relates to methods of synthesis of oligomers, including but not limited to oligopeptides, oligosaccharides and oligonucleotides, particularly oligoribonucleotides and also oligodeoxyribonucleotides, in solution systems, and ionic tag linkers for use in methods provided herein.

专利号:US-11938187-B2
优先权日:2021-06-10
标题:Methods and compositions for synthesis of two-photon cleavable phosphoramidite molecules for oligonucleotide conjugation
发明人：LO PEGGY PIK KWAN; LIU LING SUM; TAM DICK YAN
权利人:UNIV CITY HONG KONG
摘要:The syntheses of two phosphoramidite building blocks based on BNSF and BNSMB structures are disclosed. Furthermore, some common molecular intermediates have been designed and linked to the central biphenyl core of the two molecules, resulting in a versatile and cost-effective design. These compounds can be effectively introduced to DNA oligonucleotides via the well-established standard cyanoethylphosphoramidite chemistry on the nucleic acid synthesizer. Fragmentation of these BNSF- and BNSMB-functionalized DNA strands is achieved by both one-photon and two-photon photolysis of photoliable bonds of [2-(2-nitrophenyl)propoxy]carbonyl groups on BNSF and BNSMB molecules respectively, resulting in two short pieces of single-stranded DNAs. The versatile design and facile synthesis of these two-photon photocleavage phosphoramidite molecules are beneficial to synthetic chemists and photochemists for the development of new caged compounds which enables to introduce into oligonucleotides as light-triggered carriers via solid-phase synthesis for a wide range of applications in materials science, polymer, chemistry, biology and DNA nanoecthnology.

专利号:US-2024116890-A1
优先权日:2022-09-28
标 题 :Large scale synthesis of cannabinol
发明人：COLLINS ARIANNA C; CRUCES IVAN; RAY KYLE; CRUCES WESTLEY
权利人:COLORADO CHROMATOGRAPY LLC
摘要:Methods for producing cannabinol, cannabivarin, or derivatives thereof are disclosed. The methods disclosed herein can be employed for large scale synthesis or semi-synthesis of the compounds, including multi-kilogram quantities of the compounds.

专利号:US-2006264608-A1
优先权日:2001-08-03
标题 :Bi-directional synthesis of oligoguanidine transport agents
发明人：WENDER PAUL A; VANDEUSEN CHRISTOPHER L; PATTABIRAMAN KANAKA; PELKEY ERIN T; JESSOP THEODORE C
权利人:WENDER PAUL A; VANDEUSEN CHRISTOPHER L; PATTABIRAMAN KANAKA; PELKEY ERIN T; JESSOP THEODORE C
摘要:Synthesis routes that can be adapted to large scale synthesis of oligoguanidine compounds such as oligoarginine compounds are described which use a perguanidinylation step to convert a group of ω-amino groups to the corresponding guanidinyl groups. These compounds find utility as transport agents. Modified oligoguanidine compounds are also described.

专利号:US-6815214-B2
优先权日:2000-12-29
标 题 :Pharmaceutical uses and synthesis of diketopiperazines
发明人：BOYCE JIM P; HOWBERT J JEFFRY; TABONE JOHN C
权利人:CELLTECH R & D INC
摘要:The synthesis of novel diketopiperazines, their use in inhibiting cellular events such as those involving NFK-α, NFK-β and in the treatment of inflammation events, a combinatorial library of diverse diketopiperazines and process for their synthesis as a library and as individual compounds. In particular novel diketopiperazines are disclosed including their synthesis and use in cellular events such as activation of the transcription factor, nuclear factor, TNF-α, TNF-β and also apoptosis.

专利号:WO-2024012791-A1
优先权日:2022-07-11
标题 :Electrochemical synthesis of pyrazolines and pyrazoles
发明人：BÄR ROBIN MAXIMILIAN; FORD MARK JAMES; KALDAS SHERIF JAMES; WALDVOGEL SIEGFRIED; HOFMANN SILJA; LINDEN MARTIN
权利人:BAYER AG
摘要:The present invention relates to an electrochemical process for the synthesis of pyrazolines and pyrazoles of formula (I). The process can be especially used for the synthesis of the herbicide safener mefenpyr-diethyl.