CAS: 203869-80-1; 1-Boc-2-Methyl-Dl-Proline

该化合物是蛋白质中常见的一种氨基酸的分泌物衍生物,该化合物的成分为三丁氧碳基(Boc)保护组,在有机合成中通常用于保护化学反应过程中的矿害功能.在阳性环的2位置上,该甲基组的存在会造成不耐烦,影响化合物的再活性和相容性.一般而言,该化合物是白色到非白色固体的,在二氯甲烷和二甲基硫氧化物等有机溶剂中可溶解,但水中溶解性较小.其结构允许在丙二氧基合成和药物开发中潜在应用,特别是在丙基化合物的设计中.该物质组可以在酸性条件下被清除,从而推动该化合物的进一步功能化.

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上下游产品

CAS号317355-80-9 1-叔丁基2-甲基2-甲基吡咯... | CAS号15761-39-4 B°C-L-脯氨酸 | CAS号74-88-4 碘甲烷

合成工艺路线路线简述

    📜1-Boc-2-吡咯烷甲酸甲酯置于sodium Hydroxide,Lithium Hexamethyldisilazane体系中,用 四氢呋喃,甲醇,甲苯 用作溶剂,化学反应 15.33H,反应生成1-Boc-2-甲基-Dl-脯氨酸
    参考文献:四元脯氨酸衍生物的中断 Curtius 重排:无环酮和不饱和吡咯烷的流动途径
    标题:四元脯氨酸衍生物的中断 Curtius 重排:无环酮和不饱和吡咯烷的流动途径
    摘要:发现n-Boc 保护的季脯氨酸衍生物在热 Curtius 重排条件下的转化提供了一系列开环酮和不饱和吡咯烷产物,而不是预期的氨基甲酸酯物质.由于假定的n-酰基铵物种的稳定性,因此季碳上的取代基的性质决定了产品结果.此外,还开发了具有在线清除功能的连续流工艺,以简化这种转换并安全地生产克级产品.
    Doi:10.1021/acs.Joc.1C01133

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    专利信息


    专利号:US-9676783-B2
    优先权日:2008-10-22
    标 题:Method of treatment using substituted pyrazolo[1,5-A] pyrimidine compounds
    发明人：HAAS JULIA; ANDREWS STEVEN W; JIANG YUTONG; ZHANG GAN
    权利人:ARRAY BIOPHARMA INC
    摘要:Compounds useful in the synthesis of compounds for treating pain, cancer, inflammation, neurodegenerative disease or Typanosoma cruzi infection in a mammal.

    专利号:US-2024390383-A1
    优先权日:2021-09-28
    标题 :Dioxazines and their use in treatment of gba-related diseases
    发明人：NEVE SØREN; BROWN WILLIAM DALBY; THIRSTRUP KENNETH
    权利人:ZEVRA DENMARK AS
    摘要:The present invention relates to dioxazines, their synthesis, and their use for increasing GBA activity and/or levels as well as treatment of GBA-related diseases, such as Parkinson's disease.

    专利号:US-8772301-B2
    优先权日:2009-12-18
    标题 :Compounds for treating disorders mediated by metabotropic glutamate receptor 5, and methods of use thereof
    发明人：HARDY LARRY WENDELL; HEFFERNAN MICHELE L R; WU FRANK XINHE; SPEAR KERRY L; SARASWAT LAKSHMI D
    权利人:HARDY LARRY WENDELL; HEFFERNAN MICHELE L R; WU FRANK XINHE; SPEAR KERRY L; SARASWAT LAKSHMI D; SUNOVION PHARMACEUTICALS INC
    摘要:Provided herein are compounds and methods of synthesis thereof. The compounds set forth herein are useful for the treatment, prevention, and/or management of various disorders, such as neurological disorders, neurodegenerative disorders, neuropsychiatric disorders, disorders of cognition, learning or memory, gastrointestinal disorders, lower urinary tract disorder, and cancer. Compounds set forth herein modulate the activity of metabotropic glutamate receptor 5 (mGluR5) in the central nervous system or the periphery. Pharmaceutical formulations containing the compounds and their methods of use are also provided herein.

    专利号:EP-2725028-A1
    优先权日:2008-10-22
    标题 :Substituted pyrazolo[1,5-]pyrimidine compounds as intermediates in the synthesis of TRK kinase inhibitors

    专利号:EP-2725028-B1
    优先权日:2008-10-22
    标题 :Substituted pyrazolo[1,5-]pyrimidine compounds as intermediates in the synthesis of TRK kinase inhibitors

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    合成参考文献

    合成方法参考DOI号:10.1016/j.tet.2010.03.002
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