CAS: 187269-40-5; Bimosiamose

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2-[3-[5-[6-[3-[3-(Carboxymethyl)Phenyl]-4-Methoxyphenyl]Hexyl]-2-Methoxyphenyl]Phenyl]Acetic Acid 187269-48-3
2-[3-[5-[6-[3-[3-(Carboxymethyl)Phenyl]-4-Methoxyphenyl]-6-Oxohexanoyl]-2-Methoxyphenyl]Phenyl]Acetic Acid 187269-44-9
Methyl 2-[3-[2-Methoxy-5-[6-[4-Methoxy-3-[3-(2-Methoxy-2-Oxoethyl)Phenyl]Phenyl]-6-Oxohexanoyl]Phenyl]Phenyl]Acetate 204572-20-3

📜1,6-Bis[3-(3-Carboxymethylphenyl)-4-Hydroxyphenyl]Hexane置于lithium Hydroxide,硫酸,三氟化硼乙醚体系中,用 1,2-二氯乙烷,乙腈 用作溶剂,化学反应 16.0H,反应生成比莫西糖
参考文献:选择素介导的细胞粘附的新型合成抑制剂:1,6-双[3-(3-羧甲基苯基)-4-(2-α-D-甘露吡喃糖基氧基)苯基]己烷(tbc1269)的合成.
标题:选择素介导的细胞粘附的新型合成抑制剂:1,6-双[3-(3-羧甲基苯基)-4-(2-α-D-甘露吡喃糖基氧基)苯基]己烷(tbc1269)的合成.
摘要:E-选择素的高亲和力配体,唾液酸二-Lewis(x)(sle(x)le(x),1)的报道促使我们将对先前报道的基于联苯的抑制剂进行修饰,从而提供与蛋白质.分析了这些化合物抑制带有唾液酸的lewis(x)(sle(x),2)hl-60细胞与e-,P-和l-选择蛋白融合蛋白结合的能力.我们报告说,包含简单的非寡糖选择素拮抗剂的多个组成部分的二聚体或三聚体化合物抑制sle(x)依赖性结合,并具有比单体化合物显着增强的效力.增强的效力与单个选择素凝集素结构域内的其他结合相互作用一致.然而,不能排除与多个凝集素结构域的多价相互作用.
Doi:10.1021/jm9704917

专利信息

专利号:US-12098115-B2
优先权日:2016-09-15
标 题:Methods and compositions for terpenoid synthesis
发明人：GRENNING ALEXANDER JAMES
权利人:UNIV FLORIDA
摘要:In one aspect, the disclosure relates to methods for preparation of terpene and terpene-like molecules. In a further aspect, the disclosure relates to the products of the disclosed methods, i.e., terpene and terpene-like molecules prepared using the disclosed methods. Intermediates for the synthesis of a wide variety of terpenoids are γ-allyl Knoevenagel adducts or quasi γ-allyl Knoevenagel adducts are disclosed. In various aspects, methods of preparing terpenoids through these intermediates are disclosed. The methods can comprise α-alkylation of an allylic electrophile followed by ring-closure metathesis to a polycyclic terpenoid structure. In a further aspect, the disclosure pertains to terpenoid frameworks, and compounds prepared via disclosed oxidation and substitution reactions on the disclosed terpenoid frameworks. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present disclosure.

专利号:EP-1141062-B1
优先权日:1998-11-12
标题:Synthesis of energetic thermoplastic elastomers containing oligomeric urethane linkages
发明人：SANDERSON ANDREW JOHN; EDWARDS WAYNE
权利人:ALLIANT TECHSYSTEMS INC
摘要:This thermoplastic elastomer is present in a substantially solid state suitable for use as a binder for a propellant, explosive, and/or gas generant of a supplemental restraint system. The thermoplastic elastomer is formed from a composition including A blocks which are crystalline at temperatures below about 75°C and B blocks which are amorphous at temperatures above about -20°C. The A blocks are derived from oxetane derivatives and/or tetrahydrofuran derivatives. The B blocks are derived from oxetanes, tetrahydrofuran, oxiranes, and derivatives thereof. The A and B blocks are end-capped with at least one diisocyanate and linked with at least one difunctional oligomer having two functional groups which are reactive with free and unreacted isocyanate moieties of the diisocyanate.

专利号:US-6997997-B1
优先权日:1998-11-12
标 题 :Method for the synthesis of energetic thermoplastic elastomers in non-halogenated solvents
发明人：SANDERSON ANDREW J; EDWARDS WAYNE W
权利人:ALLIANT TECHSYSTEMS INC
摘要:A method is provided for preparing thermoplastic elastomers. A blocks of the thermoplastic elastomers are crystalline at temperatures below about 60° C. and are derived from oxetane derivatives and/or tetrahydrofuran derivatives. B blocks of the thermoplastic elastomer are amorphous above about −20° C. and are derived from oxetanes, tetrahydrofuran, oxiranes, and derivatives thereof. According to this method, the A and B blocks are dissolved into solution containing a non-halogenated solvent, preferably tetrahydrofuran, then dried by azeotropic distillation. The dried blocks are end-capped with a diisocyanate, preferably a diisocyanate having one isocyanate moiety substantially more reactive with the terminal groups of the blocks than the other isocyanate moiety of the diisocyanate. The end-capped blocks are then linked together with a linking compound.

专利号:US-2006157173-A1
优先权日:1998-11-12
标题:Synthesis of energetic thermoplastic elastomers containing both polyoxirane and polyoxetane blocks

专利号:US-2007191309-A1
优先权日:2004-03-01
标题 :Pyrrolobenzodiazepines as key intermediates in the synthesis of dimeric cytotoxic pyrrolobenzodiazepines

专利号:US-2007179100-A1
优先权日:2003-04-09
标 题:Protected monomers
发明人：MANOHARAN MUTHIAH
权利人:MANOHARAN MUTHIAH
摘要:This invention relates to protected monomers for the synthesis of iRNA agents.