CAS: 175278-00-9; 1-Iodo-2-(Trifluoromethoxy)Benzene

上下游产品

CAS号456-55-3 三氟甲氧基苯 | CAS号334778-34-6 2-(trifluoromet... | CAS号175676-54-7 2-氨基-2-(三氟甲氧基)联苯

三氟甲氧基苯置于四甲基乙二胺,仲丁基锂,碘体系中,用 四氢呋喃 用作溶剂,以99%的收率获得2-碘三氟甲氧基苯
参考文献:三氟甲氧基芳烃的选择性芳族碳-氧键裂解:三氟甲氧基作为可转换的导向基团
标题:三氟甲氧基芳烃的选择性芳族碳-氧键裂解:三氟甲氧基作为可转换的导向基团
摘要:开发了一种有效激活三氟甲氧基芳烃中芳香族c-O键的有效方法.在用金属钠/氯代三甲基硅烷系统处理后,三氟甲氧基芳烃经历还原性脱烷氧基化以提供相应的芳基硅烷.还描述了本反应与原金属化结合的合成应用.
Doi:10.1016/j.Tetlet.2008.08.002

专利信息

专利号:US-7884125-B2
优先权日:2008-04-30
标 题:Straightforward entry to 7-azabicyclo[2.2.1]heptane-1-carbonitriles and subsequent synthesis of epibatidine analogues
发明人：STEVENS CHRISTIAN; HEUGEBAERT THOMAS
权利人:UNIV GENT
摘要:The present invention relates to a group of substituted-7-azabicyclo-[2.2.1]heptyl derivatives with biological activity. The present invention also relates to synthetic methods for producing said substituted-7-azabicyclo-[2.2.1]heptyl derivatives. The present invention also relates to certain intermediates for producing such substituted-7-azabicyclo-[2.2.1]heptyl derivatives, as well as a synthetic method for producing such intermediates. The present invention also relates to pharmaceutical compositions comprising such substituted-7-azabicyclo-[2.2.1]heptyl derivatives, as well as their use as medicaments for the treatment of diseases mediated by a Nicotinic Acetylcholine Receptor or a receptor being a member of the Neurotransmitter-gated Ion Channel Superfamily, such as pain, Alzheimer's disease, Parkinson's disease, schizophrenia, epilepsy and nicotine addiction.

专利号:WO-0009116-A1
优先权日:1998-08-14
标 题:Grp receptor ligands
发明人：XIANG JIA-NING; KARPINSKI JOSEPH M; CHRISTENSEN SIEGFRIED B IV
权利人:SMITHKLINE BEECHAM CORP; XIANG JIA NING; KARPINSKI JOSEPH M; CHRISTENSEN SIEGFRIED B IV
摘要:Novel GRP receptor antagonists are provided. Methods of using the present compounds to antagonize GRP receptors are also provided. The present invention further involves the synthesis of the present compounds.

专利号:US-2009275616-A1
优先权日:2008-04-30
标 题 :Straightforward entry to 7-azabicyclo[2.2.1]heptane-1-carbonitriles and subsequent synthesis of epibatidine analogues

专利号:CN-105646134-B
优先权日:2016-02-23
标题:A method for highly selective synthesis of iodobenzene compounds

专利号:CN-105646134-A
优先权日:2016-02-23
标题 :A method for highly selective synthesis of iodobenzene compounds

专利号:WO-0009115-A1
优先权日:1998-08-14
标 题 :Grp receptor ligands
发明人：XIANG JIA-NING; OSIFO IRENNEGBE KELLY; KARPINSKI JOSEPH M; CHRISTENSEN SIEGFRIED B IV
权利人:SMITHKLINE BEECHAM CORP; XIANG JIA NING; OSIFO IRENNEGBE KELLY; KARPINSKI JOSEPH M; CHRISTENSEN SIEGFRIED B IV
摘要:Novel GRP receptor antagonists are provided. Methods of using the present compounds to antagonize GRP receptors are also provided. The present invention further involves the synthesis of the present compounds.