CAS: 16395-58-7; (S)-1-Acetylpyrrolidine-2-Carboxamide

相似化合物

30130-35-9 151378-30-2 117368-39-5

上下游产品

CAS号68-95-1 N-乙酰-L-脯氨酸 | CAS号75-36-5 乙酰氯 | CAS号7531-52-4 L-脯氨酰胺 | CAS号108-05-4 乙酸乙烯酯 | CAS号108-24-7 乙酸酐 | CAS号147-85-3 脯氨酸

📜N-乙酰-L-脯氨酸置于ammonium Hydroxide,氯化亚砜体系中,用 二氯甲烷 用作溶剂,化学反应 9.0H,反应生成N-乙酰-L-脯氨酰胺
参考文献:L-脯氨酰胺的合成方法
标题:L-脯氨酰胺的合成方法
摘要:本发明属于有机合成领域,公开了一种l‑脯氨酰胺的合成方法该方法:S1:以l‑脯氨酸为起始原料,溶于水后与醋酐进行反应,反应结束后经萃取,干燥后制得n‑乙酰基‑l‑脯氨酸;S2:以s1制得的n‑乙酰基‑l‑脯氨酸为原料,在溶剂体系下,与氯化亚砜进行反应,反应后浓缩干燥制得化合物;S3:以s2制得的化合物为原料,滴加氨水进行反应,过滤后制得1‑乙酰基‑2‑吡咯烷甲酰胺;S4:以s3制得的1‑乙酰基‑2‑吡咯烷甲酰胺为原料,滴加hcl进行反应,反应结束后浓缩,过滤,干燥制得l‑脯氨酰胺.本发明提出的合成方法的反应过程中使用的均为常见试剂原料,成本低,反应条件温和,手性纯度高,收率高,环境压力小,利于大规模生产.

专利信息

专利号:US-10905769-B2
优先权日:2015-11-13
标 题:Peptide and peptide mimetic binding antagonists of polo-like kinase 1 polo box domain and methods of use
发明人：BURKE JR TERRENCE R; HYMEL DAVID T; TSUJI KOHEI
权利人:THE US SECRETARY DEPARTMENT OF HEALTH & HUMAN SERVICES
摘要:The description provides novel compounds that may serve as anticancer therapeutics. The compounds of the description bind to polo-like kinases through the polo-box domain. The peptide derivatives of the description have achieved improved efficacy in biochemical assays against Plk1. Exemplary compounds of the description include macrocyclic peptidomimetics with high affinity and selectivity for polo-like kinases, which may provide the basis for a new genre of anticancer therapeutics. Other exemplary compounds of the description include bi-valent compounds with that bind to polo-like kinases through both kinase domain and polo-box domain simultaneously by incorporating additional moieties that target Plk1 kinase domain, which significantly enhances affinitity relative and may provide the basis for a new genre of anticancer therapeutics. The description also provides methods of use, methods of preparation, compositions, and kits thereof. Further, the description provides a novel method of design and/or synthesis of phosphoryl-derived peptide derivatives useful as therapeutic agents.

专利号:US-5219741-A
优先权日:1989-09-06
标题:Method of making L-proline using an N-acyl-L-protine acylase
发明人：GROEGER ULRICH; LEUCHTENBERGER WOLFGANG; DRAUZ KARLHEINZ
权利人:DEGUSSA
摘要:A microbiologically produced, thermostable N-acylproline-acylase and a process for obtaining it from Comamonas testosteroni DSM 5416 and Alcaligenes denitrificans DSM 5417. The enzyme is useful for the synthesis of L-proline from various N-acyl-L-proline derivatives.

专利号:US-5120652-A
优先权日:1989-09-06
标 题 :Substantially purified n-acyl-l-proline acylase from comamonas testosteroni dsm 5416 and alcaligenes denitrificans dsm 5417
发明人：GROEGER ULRICH; LEUCHTENBERGER WOLFGANG; DRAUZ KARLHEINZ
权利人:DEGUSSA
摘要:A substantially purified N-acyl-L-proline-acylase from Comamonas testosteroni DSM 5416 and Alcaligenes denitrificans DSM 5417. The enzyme is useful for the synthesis of L-proline from various N-acyl-L-proline derivatives.