CAS: 156-06-9; Phenylpyruvic Acid

该化合物是有机化合物,其结构特征是其结构,包括一个附于一种丙酸酸的苯基组,它看起来像是白的,黄色的晶状固体,在水和有机溶剂中可以溶解,该化合物在代谢途径中的作用显著,特别是在苯丙胺(PKU)方面,这是一种遗传障碍,人体无法适当代谢苯丙胺,导致苯丙胺累积,其化学配方为C9H10O3,并有一个碳盒酸功能组,有助于其酸性,苯丙酸可以参与各种化学反应,包括酯化和脱色体反应,此外,还对其潜在的生物活动进行了研究,包括对...

结构式图片

相似化合物

20312-36-1 7326-19-4 828-01-3

欧盟法规

ECHA物质C&L通报REACH预注册

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合成工艺路线路线简述

  • 合成目标产物 3-Phenylpyruvic Acid 主要起始原料 Phenylpropiolic Acid
  • (文献来源)合成步骤主要原料 Phenylpropiolic Acid
📜3-Phenyl-2-Sulfanylpropenoic Acid置于氨体系中,化学反应生成苯丙酮酸
参考文献:Graenacher,Helvetica Chimica Acta,1922,Vol. 5,P. 614,619
标题:Graenacher,Helvetica Chimica Acta,1922,Vol. 5,P. 614,619

海关参考信息

专利信息


专利号:US-6133018-A
优先权日:1997-06-02
标 题 :Enzymatic synthesis of chiral amines using -2-amino propane as amine donor
发明人:WU WEI; BHATIA MOHIT B; LEWIS CRAIG M; LANG WEI; WANG ALICE L; MATCHAM GEORGE W
权利人:CELGRO
摘要:2-Aminopropane is used as the amine donor in the stereoselective synthesis of a chiral amine from a ketone with a transaminase. In a typical embodiment, (S)-1-methoxy-2-aminopropane is prepared by bringing methoxyacetone into contact with a transaminase in the presence of 2-aminopropane as an amine donor until a substantial amount of methoxyacetone is converted to (S)-1-methoxy-2-aminopropane and 2-aminopropane is converted to acetone. In a second embodiment, L-alanine is prepared by bringing pyruvic acid into contact with a transaminase in the presence of 2-aminopropane as an amine donor.

专利号:EP-1075534-B8
优先权日:1998-03-11
标 题 :Improvements in the enzymatic synthesis of chiral amines
发明人:WU WEI; BHATIA MOHIT B; LEWIS CRAIG M; LANG WEI; WANG ALICE; MATCHAM GEORGE W
权利人:CELGRO
摘要:2-Aminopropane is used as the amine donor in the stereoselective synthesis of a chiral amine from a ketone with a transaminase. In a typical embodiment, (S)-1-methoxy-2-aminopropane is prepared by bringing methoxyacetone into contact with a transaminase in the presence of 2-aminopropane as an amine donor until a substantial amount of methoxyacetone is converted to (S)-1-methoxy-2-aminopropane and 2-aminopropane is converted to acetone. In a second embodiment, L-alanine is prepared by bringing pyruvic acid into contact with a transaminase in the presence of 2-aminopropane as an amine donor.

专利号:WO-2018157942-A1
优先权日:2017-03-03
标题:Cell-free synthesis of isotopic labelled proteins from amino-acids precursors
发明人:CRUBLET ELODIE; IMBERT LIONEL; GANS PIERRE; BOISBOUVIER JÉRÔME; KERFAH RIME
权利人:NMR BIO; COMMISSARIAT ENERGIE ATOMIQUE; CENTRE NAT RECH SCIENT; UNIV GRENOBLE ALPES
摘要:Process of cell-free synthesis of a target protein, comprising at least the following steps: a. providing at least one precursor of an amino-acid, a cell-free extract comprising means for transforming said precursor of an amino-acid into the corresponding amino-acid, at least one tRNA for integrating said amino-acid into the corresponding target protein, in which the at least one precursor of amino-acid is an alpha-keto acid, with the proviso that 2-ketobutyric acid is excluded, b. mixing the compounds provided in step a) to obtain a mixture, c. adding to said mixture obtained in step b) a DNA or a mRNA coding to said target protein in order to produce said target protein.

专利号:WO-2023198025-A1
优先权日:2022-04-11
标题:Synthesis method and synthesis device for organic nitrogen-containing compound
发明人:LI GUANGQIN; Liao Peisen; XIAN JIAHUI; LI SUISHENG; ZHANG YAWEI
权利人:UNIV SUN YAT SEN
摘要:The present invention relates to the field of organic synthesis, specifically to a synthesis method and synthesis device for an organic nitrogen-containing compound. Provided in the present invention is a synthesis method for an organic nitrogen-containing compound. In the method provided in the present invention, a porous carbon material is used as a catalyst, organic nitrogen-containing compounds such as an oxime, an amine, a nitrile and an amino acid are synthesized by means of an electro-catalysis method, byproducts are unlikely to generate, and the method is safe and environmentally friendly. Experiments show that organic nitrogen-containing compounds such as an amino acid, an oxime, an amine and a nitrile are successfully synthesized by using the method of the present invention, and the method has good Faraday efficiency and yield. In the present application, the synthesis of the above organic nitrogen-containing compounds can be realized by using nitrogen oxide waste gas or waste water as a raw material; and by converting the nitrogen oxide waste gas or waste water, the utilization of waste is realized, and the benefits are maximized. Further provided in the present invention is a synthesis device for an organic nitrogen-containing compound, which device is used for solving the defects of high energy consumption, long consumption time, and complex product separation and purification of existing synthesis methods.

专利号:US-6066780-A
优先权日:1991-04-26
标题 :Modification of lignin synthesis in plants
发明人:BOUDET ALAIN MICHEL; INZE DIRK GUSTAAF; SCHUCH WOLFGANG WALTER
权利人:ZENECA LTD
摘要:The synthesis of lignin by plants is controlled by transformation of the plant genome with a recombinant gene construct which contains the gene specifying an enzyme critical to the synthesis of a lignin precursor, which gene may be in antisense orientation so that it is transcribed to mRNA having a sequence complementary to the equivalent mRNA transcribed from the endogenous gene thus leading to suppression of lignin synthesis. If the recombinant gene has the lignin enzyme gene in normal, or 'sense' orientation, increased production of the enzyme may occur when the insert is the full length DNA but suppression may occur it only a partial sequence is employed.

专利号:US-5202235-A
优先权日:1986-08-18
标题 :Enzymatic method for the synthesis and separation of peptides
发明人:IACOBUCCI GUILLERMO A
权利人:COCA COLA CO
摘要:The present invention provides a method for the enzymatic synthesis of peptides accomplished by shifting the chemical equilibrium that exists in a reaction mixture between charged or ionized reacting amino acids and uncharged or non-ionized peptide product in the presence of a proteolytic enzyme such as thermolysin. The equilibrium is shifted by diffusion of the uncharged peptide product across an ion-rejection membrane which removes the uncharged peptide from the reaction mixture and preferably the diffused uncharged peptide is quickly converted to a charged species that cannot back-diffuse into the reaction mixture so that the uncharged peptide is effectively 'pulled' across the membrane.

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主要参考文献

[参考文献]: Gregory Kaler, Et Al. Structural Variation Governs Substrate Specificity For Organic Anion Transporter (Oat) Homologs. Potential Remote Sensing By Oat Family Members. J Biol Chem. 2007 Aug 17;282(33):23841-53.
[参考文献]: J D Shoemaker, Et Al. Automated Screening Of Urine Samples For Carbohydrates, Organic And Amino Acids After Treatment With Urease. J Chromatogr. 1991 Jan 2;562(1-2):125-38.
[参考文献]: Jianghua Jia, Et Al. Bioconversion Of Phenylpyruvate To Phenyllactate: Gene Cloning, Expression, And Enzymatic Characterization Of D- And L1-Lactate Dehydrogenases From Lactobacillus Plantarum Sk002. Appl Biochem Biotechnol. 2010 Sep;162(1):242-51.
[参考文献]: Shuhuai Yu, Et Al. Characterization Of D-Lactate Dehydrogenase Producing D-3-Phenyllactic Acid From Pediococcus Pentosaceus. Biosci Biotechnol Biochem. 2012;76(4):853-5.
[参考文献]: Tania Veiga, Et Al. Resolving Phenylalanine Metabolism Sheds Light On Natural Synthesis Of Penicillin G In Penicillium Chrysogenum. Eukaryot Cell. 2012 Feb;11(2):238-49.

合成参考文献


参考文献:10.1105/tpc.111.086975
摘要:Dal Cin V, Tieman DM, Tohge T, McQuinn R, de Vos RC, Osorio S, Schmelz EA, Taylor MG, Smits-Kroon MT, Schuurink RC, Haring MA, Giovannoni J, Fernie AR, Klee HJ. Identification of genes in the phenylalanine metabolic pathway by ectopic expression of a MYB transcription factor in tomato fruit. Plant Cell. 2011 Jul;23(7):2738–53.
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